Factor VIII Coagulation Pathway Quiz

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Questions and Answers

Which of the following factors is NOT synthesized in the liver?

  • Factor II
  • Factor VII
  • Fibrinogen
  • Factor XIII (correct)

What is the genetic disorder associated with a defect in platelet adhesion due to an autosomal recessive defect in platelet membrane glycoprotein (GP Ib)?

  • Isoimmune Thrombocytopenia
  • Thrombasthenia
  • Vitamin K Deficiency
  • Bernard-Soulier Syndrome (correct)

What is the effect of aspirin on platelet function?

  • Inhibition of cyclooxygenase, leading to suppression of TXA2 synthesis (correct)
  • Stimulation of cyclooxygenase, leading to increased TXA2 synthesis
  • Inhibition of cyclooxygenase, leading to increased TXA2 synthesis
  • Stimulation of cyclooxygenase, leading to decreased TXA2 synthesis

What is the characteristic feature of Thrombocytopenia?

<p>Increased platelet utilization (C)</p> Signup and view all the answers

Which of the following genetic disorders is associated with an autosomal recessive defect in platelet membrane glycoprotein (GP IIb & IIIa)?

<p>Thrombasthenia (A)</p> Signup and view all the answers

What is the effect of Vitamin K Deficiency on coagulation?

<p>Increased PT, normal aPTT (B)</p> Signup and view all the answers

Which factor is primarily produced by hepatocytes and activated by thrombin?

<p>Factor VIII (B)</p> Signup and view all the answers

Which genetic disorder is caused by a deficiency in Factor VIII?

<p>Hemophilia A (A)</p> Signup and view all the answers

Which coagulation factor deficiency is most commonly associated with bleeding into joints and crippling arthropathy?

<p>Factor VIII (A)</p> Signup and view all the answers

Which of the following is an autosomal dominant genetic disorder related to coagulation factors?

<p>Von Willebrand's Disease (B)</p> Signup and view all the answers

Which factor is activated by tissue thromboplastin to accelerate the production of thrombin from prothrombin?

<p>Factor III (A)</p> Signup and view all the answers

Which of these factors play a role in the formation of a stable fibrin clot?

<p>Factor XIII (B)</p> Signup and view all the answers

Which factor is involved in the formation of the intrinsic tenase complex?

<p>Factor VIII (A)</p> Signup and view all the answers

Which factor is a large carrier protein that is governed by genes carried on the X chromosome?

<p>Factor VIII (D)</p> Signup and view all the answers

Which factor is associated with the presence of ultralarge von Willebrand Factor in TTP?

<p>ADAMTS-13 (B)</p> Signup and view all the answers

Which coagulation factor is associated with sex-linked inheritance and a high rate of spontaneous mutation?

<p>Factor VIII (A)</p> Signup and view all the answers

Which of the following coagulation factor deficiencies is most likely to present with easy bruisability instead of bleeding into joints?

<p>Von Willebrand's Disease (C)</p> Signup and view all the answers

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