Factor VIII Coagulation Pathway Quiz
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Factor VIII Coagulation Pathway Quiz

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Questions and Answers

Which of the following factors is NOT synthesized in the liver?

  • Factor II
  • Factor VII
  • Fibrinogen
  • Factor XIII (correct)

    • What is the genetic disorder associated with a defect in platelet adhesion due to an autosomal recessive defect in platelet membrane glycoprotein (GP Ib)?

  • Isoimmune Thrombocytopenia
  • Thrombasthenia
  • Vitamin K Deficiency
  • Bernard-Soulier Syndrome (correct)

    • What is the effect of aspirin on platelet function?

  • Inhibition of cyclooxygenase, leading to suppression of TXA2 synthesis (correct)
  • Stimulation of cyclooxygenase, leading to increased TXA2 synthesis
  • Inhibition of cyclooxygenase, leading to increased TXA2 synthesis
  • Stimulation of cyclooxygenase, leading to decreased TXA2 synthesis

    • What is the characteristic feature of Thrombocytopenia?

    <p>Increased platelet utilization</p> Signup and view all the answers

    Which of the following genetic disorders is associated with an autosomal recessive defect in platelet membrane glycoprotein (GP IIb & IIIa)?

    <p>Thrombasthenia</p> Signup and view all the answers

    What is the effect of Vitamin K Deficiency on coagulation?

    <p>Increased PT, normal aPTT</p> Signup and view all the answers

    Which factor is primarily produced by hepatocytes and activated by thrombin?

    <p>Factor VIII</p> Signup and view all the answers

    Which genetic disorder is caused by a deficiency in Factor VIII?

    <p>Hemophilia A</p> Signup and view all the answers

    Which coagulation factor deficiency is most commonly associated with bleeding into joints and crippling arthropathy?

    <p>Factor VIII</p> Signup and view all the answers

    Which of the following is an autosomal dominant genetic disorder related to coagulation factors?

    <p>Von Willebrand's Disease</p> Signup and view all the answers

    Which factor is activated by tissue thromboplastin to accelerate the production of thrombin from prothrombin?

    <p>Factor III</p> Signup and view all the answers

    Which of these factors play a role in the formation of a stable fibrin clot?

    <p>Factor XIII</p> Signup and view all the answers

    Which factor is involved in the formation of the intrinsic tenase complex?

    <p>Factor VIII</p> Signup and view all the answers

    Which factor is a large carrier protein that is governed by genes carried on the X chromosome?

    <p>Factor VIII</p> Signup and view all the answers

    Which factor is associated with the presence of ultralarge von Willebrand Factor in TTP?

    <p>ADAMTS-13</p> Signup and view all the answers

    Which coagulation factor is associated with sex-linked inheritance and a high rate of spontaneous mutation?

    <p>Factor VIII</p> Signup and view all the answers

    Which of the following coagulation factor deficiencies is most likely to present with easy bruisability instead of bleeding into joints?

    <p>Von Willebrand's Disease</p> Signup and view all the answers

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