30 Questions
Which factor deficiency is referred to as Hemophilia A?
Factor Vlll
What does Factor VWF:Ag represent?
Antigenic properties of Factor VIII
Which group of coagulation factors is consumed during coagulation and increased in inflammation, trauma, stress, and pregnancy?
Thrombin-sensitive group
What does Ristocetin co-factor activity refer to?
Platelet aggregation property of Factor VIII
Which factors are part of the Thrombin-sensitive group of coagulation factors?
Factors I, V, VII, VIII
What is the main difference between the Thrombin-sensitive group and the Prothrombin group of coagulation factors?
Vitamin K synthesis requirement vs. no need for synthesis
What are platelets referred to when they adhere to the site of injury and are activated by both low-level thrombin and collagen?
COAT platelets
What complexes do platelets provide a surface for formation and amplification of?
Intrinsic tenase and prothrombinase complexes
Which factor binds to platelet membranes and becomes a receptor for factor Xa during the initiation phase?
Factor Va
What complex is formed when factor 1Xa binds to V111a on the platelet membrane?
Intrinsic tenase complex
Which complex activates factor X at a 50 to 100 fold higher rate compared to the extrinsic tenase complex?
Intrinsic tenase complex
What prevents clotting from spreading to other parts of the body according to the text?
Endothelium and protease inhibitors
What is the main component of the intrinsic tenase complex?
Factor IXa
Which complex is responsible for converting prothrombin to thrombin?
Prothrombinase
What is a marker for thrombin generation in plasma?
Prothrombin fragment 1.2 (F1.2)
Which factor deficiency can lead to significant bleeding despite an intact intrinsic pathway?
Factor VIIa deficiency
Which components are part of the extrinsic tenase complex?
Factor VIIa and TF
What happens when there is thrombin generation in the body?
Coagulation follows
What is the role of Thrombin in hemostasis?
Induces platelet activation and aggregation
Which factor is converted to Factor XIIIa in coagulation?
Factor XIII
What is the function of Protein C in blood coagulation?
Inhibits Factors Va & VIIIa
How does Protein S contribute to blood coagulation?
Acts as a cofactor of Protein C to enhance inactivation of Factors Va and VIIIa
What is the main function of Thrombomodulin in the clotting cascade?
Activates protein C
Which protein may increase the risk of thrombosis when its free levels decrease due to increased plasma C4bBP?
Protein S
Which plasma protein is covalently incorporated into fibrin mesh by factor XIIIa during cross-linking of fibrin polymers?
Fibronectin
What is the role of TPA in the process of fibrinolysis?
Hydrolyzes and activates bound plasminogen
Which acute phase reactants increase in levels during inflammation, trauma, stress, and infections?
Von Willebrand Factor (VWF)
What is the primary function of thrombin in the coagulation pathway?
Converts fibrinogen to fibrin
Which enzyme regulates coagulation activation by acting on protein C?
Thrombin
What is the role of plasmin in the fibrinolytic system?
Hydrolyzes and activates bound plasminogen
Test your knowledge on coagulation factors such as Factor VIII and VWF. Learn about the functions and deficiencies related to these important blood clotting proteins.
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