Coagulation Factors Quiz
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Questions and Answers

Which factor deficiency is referred to as Hemophilia A?

  • Factor VlllC
  • Factor VWF
  • Factor Vlll (correct)
  • Factor V

    • What does Factor VWF:Ag represent?

  • Antigenic properties of Factor VIII (correct)
  • Plasma concentration of Factor VIII
  • Vitamin K dependent group
  • Ristocetin co-factor activity

    • Which group of coagulation factors is consumed during coagulation and increased in inflammation, trauma, stress, and pregnancy?

  • Prothrombin group
  • Vitamin K dependent group
  • Fibrinogen group
  • Thrombin-sensitive group (correct)

    • What does Ristocetin co-factor activity refer to?

    <p>Platelet aggregation property of Factor VIII</p> Signup and view all the answers

    Which factors are part of the Thrombin-sensitive group of coagulation factors?

    <p>Factors I, V, VII, VIII</p> Signup and view all the answers

    What is the main difference between the Thrombin-sensitive group and the Prothrombin group of coagulation factors?

    <p>Vitamin K synthesis requirement vs. no need for synthesis</p> Signup and view all the answers

    What are platelets referred to when they adhere to the site of injury and are activated by both low-level thrombin and collagen?

    <p>COAT platelets</p> Signup and view all the answers

    What complexes do platelets provide a surface for formation and amplification of?

    <p>Intrinsic tenase and prothrombinase complexes</p> Signup and view all the answers

    Which factor binds to platelet membranes and becomes a receptor for factor Xa during the initiation phase?

    <p>Factor Va</p> Signup and view all the answers

    What complex is formed when factor 1Xa binds to V111a on the platelet membrane?

    <p>Intrinsic tenase complex</p> Signup and view all the answers

    Which complex activates factor X at a 50 to 100 fold higher rate compared to the extrinsic tenase complex?

    <p>Intrinsic tenase complex</p> Signup and view all the answers

    What prevents clotting from spreading to other parts of the body according to the text?

    <p>Endothelium and protease inhibitors</p> Signup and view all the answers

    What is the main component of the intrinsic tenase complex?

    <p>Factor IXa</p> Signup and view all the answers

    Which complex is responsible for converting prothrombin to thrombin?

    <p>Prothrombinase</p> Signup and view all the answers

    What is a marker for thrombin generation in plasma?

    <p>Prothrombin fragment 1.2 (F1.2)</p> Signup and view all the answers

    Which factor deficiency can lead to significant bleeding despite an intact intrinsic pathway?

    <p>Factor VIIa deficiency</p> Signup and view all the answers

    Which components are part of the extrinsic tenase complex?

    <p>Factor VIIa and TF</p> Signup and view all the answers

    What happens when there is thrombin generation in the body?

    <p>Coagulation follows</p> Signup and view all the answers

    What is the role of Thrombin in hemostasis?

    <p>Induces platelet activation and aggregation</p> Signup and view all the answers

    Which factor is converted to Factor XIIIa in coagulation?

    <p>Factor XIII</p> Signup and view all the answers

    What is the function of Protein C in blood coagulation?

    <p>Inhibits Factors Va &amp; VIIIa</p> Signup and view all the answers

    How does Protein S contribute to blood coagulation?

    <p>Acts as a cofactor of Protein C to enhance inactivation of Factors Va and VIIIa</p> Signup and view all the answers

    What is the main function of Thrombomodulin in the clotting cascade?

    <p>Activates protein C</p> Signup and view all the answers

    Which protein may increase the risk of thrombosis when its free levels decrease due to increased plasma C4bBP?

    <p>Protein S</p> Signup and view all the answers

    Which plasma protein is covalently incorporated into fibrin mesh by factor XIIIa during cross-linking of fibrin polymers?

    <p>Fibronectin</p> Signup and view all the answers

    What is the role of TPA in the process of fibrinolysis?

    <p>Hydrolyzes and activates bound plasminogen</p> Signup and view all the answers

    Which acute phase reactants increase in levels during inflammation, trauma, stress, and infections?

    <p>Von Willebrand Factor (VWF)</p> Signup and view all the answers

    What is the primary function of thrombin in the coagulation pathway?

    <p>Converts fibrinogen to fibrin</p> Signup and view all the answers

    Which enzyme regulates coagulation activation by acting on protein C?

    <p>Thrombin</p> Signup and view all the answers

    What is the role of plasmin in the fibrinolytic system?

    <p>Hydrolyzes and activates bound plasminogen</p> Signup and view all the answers

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