Coagulation Factors Quiz
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Questions and Answers

Which factor deficiency is referred to as Hemophilia A?

  • Factor VlllC
  • Factor VWF
  • Factor Vlll (correct)
  • Factor V

What does Factor VWF:Ag represent?

  • Antigenic properties of Factor VIII (correct)
  • Plasma concentration of Factor VIII
  • Vitamin K dependent group
  • Ristocetin co-factor activity

Which group of coagulation factors is consumed during coagulation and increased in inflammation, trauma, stress, and pregnancy?

  • Prothrombin group
  • Vitamin K dependent group
  • Fibrinogen group
  • Thrombin-sensitive group (correct)

What does Ristocetin co-factor activity refer to?

<p>Platelet aggregation property of Factor VIII (C)</p> Signup and view all the answers

Which factors are part of the Thrombin-sensitive group of coagulation factors?

<p>Factors I, V, VII, VIII (B)</p> Signup and view all the answers

What is the main difference between the Thrombin-sensitive group and the Prothrombin group of coagulation factors?

<p>Vitamin K synthesis requirement vs. no need for synthesis (D)</p> Signup and view all the answers

What are platelets referred to when they adhere to the site of injury and are activated by both low-level thrombin and collagen?

<p>COAT platelets (D)</p> Signup and view all the answers

What complexes do platelets provide a surface for formation and amplification of?

<p>Intrinsic tenase and prothrombinase complexes (B)</p> Signup and view all the answers

Which factor binds to platelet membranes and becomes a receptor for factor Xa during the initiation phase?

<p>Factor Va (A)</p> Signup and view all the answers

What complex is formed when factor 1Xa binds to V111a on the platelet membrane?

<p>Intrinsic tenase complex (B)</p> Signup and view all the answers

Which complex activates factor X at a 50 to 100 fold higher rate compared to the extrinsic tenase complex?

<p>Intrinsic tenase complex (B)</p> Signup and view all the answers

What prevents clotting from spreading to other parts of the body according to the text?

<p>Endothelium and protease inhibitors (D)</p> Signup and view all the answers

What is the main component of the intrinsic tenase complex?

<p>Factor IXa (B)</p> Signup and view all the answers

Which complex is responsible for converting prothrombin to thrombin?

<p>Prothrombinase (D)</p> Signup and view all the answers

What is a marker for thrombin generation in plasma?

<p>Prothrombin fragment 1.2 (F1.2) (A)</p> Signup and view all the answers

Which factor deficiency can lead to significant bleeding despite an intact intrinsic pathway?

<p>Factor VIIa deficiency (A)</p> Signup and view all the answers

Which components are part of the extrinsic tenase complex?

<p>Factor VIIa and TF (A)</p> Signup and view all the answers

What happens when there is thrombin generation in the body?

<p>Coagulation follows (C)</p> Signup and view all the answers

What is the role of Thrombin in hemostasis?

<p>Induces platelet activation and aggregation (A)</p> Signup and view all the answers

Which factor is converted to Factor XIIIa in coagulation?

<p>Factor XIII (D)</p> Signup and view all the answers

What is the function of Protein C in blood coagulation?

<p>Inhibits Factors Va &amp; VIIIa (A)</p> Signup and view all the answers

How does Protein S contribute to blood coagulation?

<p>Acts as a cofactor of Protein C to enhance inactivation of Factors Va and VIIIa (A)</p> Signup and view all the answers

What is the main function of Thrombomodulin in the clotting cascade?

<p>Activates protein C (C)</p> Signup and view all the answers

Which protein may increase the risk of thrombosis when its free levels decrease due to increased plasma C4bBP?

<p>Protein S (A)</p> Signup and view all the answers

Which plasma protein is covalently incorporated into fibrin mesh by factor XIIIa during cross-linking of fibrin polymers?

<p>Fibronectin (A)</p> Signup and view all the answers

What is the role of TPA in the process of fibrinolysis?

<p>Hydrolyzes and activates bound plasminogen (B)</p> Signup and view all the answers

Which acute phase reactants increase in levels during inflammation, trauma, stress, and infections?

<p>Von Willebrand Factor (VWF) (C)</p> Signup and view all the answers

What is the primary function of thrombin in the coagulation pathway?

<p>Converts fibrinogen to fibrin (B)</p> Signup and view all the answers

Which enzyme regulates coagulation activation by acting on protein C?

<p>Thrombin (D)</p> Signup and view all the answers

What is the role of plasmin in the fibrinolytic system?

<p>Hydrolyzes and activates bound plasminogen (A)</p> Signup and view all the answers

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