Hematopoietic Neoplasia: Blood Smear Analysis

Which characteristic is commonly associated with canine lymphoma?

In dogs, what is the most common anatomical location for lymphoma?

What does classifying lymphoma based on clinical stage primarily help determine?

What is the significance of a 'spike' formation in PCR products after performing PARR (PCR for Antigen Receptor Rearrangement)?

Which of the following is NOT a typical characteristic of non-indolent lymphomas in dogs?

Which characteristic is most indicative of 'high grade' lymphoma based on histopathology?

What is a key feature of indolent lymphoma marginal zone?

According to the presented prognostic factors in dogs, which immunophenotype typically has a better MST (Mean Survival Time)?

What is a typical finding in acute leukemia?

What CBC finding is expected with acute leukemia?

What is usually required to diagnose acute leukemia?

Which statement accurately contrasts acute and chronic leukemias?

A dog presents with fever, moderate leukocytosis, thrombocytopenia and >20% blasts in marrow. Which diagnostic test would be most useful to classify the leukemia?

What is a key difference between leukemia and 'leukemic' as described in the presentation?

What does it suggest if a horse has lymphocytosis and a monoclonal T cell receptor gene rearrangement?

Which is a diagnostic criteria for multiple myeloma?

What is the function of serum protein electrophoresis in diagnosing multiple myeloma?

When evaluating a serum protein electrophoresis, what finding is most suggestive of multiple myeloma?

What characterizes 'plasmacytosis'?

What is a key feature of Histiocytic sarcoma?

Which feature is characteristic of histiocytic sarcoma cells?

Which diagnostic approach provides the most detailed immunophenotype?

Which of the following is most suggestive of Stage V lymphoma?

Which technique is LEAST likely to be useful when distinguishing between Lymphoma (LMA) or acute leukemia?

Which neoplasm can secrete a single paraprotein?

What cells are affected in Histiocytic disorders?

A veterinary professional is presented with a blood smear exhibiting a predominance of blast cells. Which of the following should be the MOST immediate concern?

When categorizing canine hematopoietic neoplasias, which factor decisively distinguishes between acute lymphoid leukemia (ALL) and acute myeloid leukemia (AML)?

Which statement accurately reflects the role of immunohistochemistry (IHC) in diagnosing lymphoma?

What is the MOST critical factor in distinguishing between chronic lymphocytic leukemia (CLL) and reactive lymphocytosis?

An 8-year-old Labrador Retriever presents with fever, moderate leukocytosis, atypical mononuclear cells, and moderate thrombocytopenia. Bone marrow cytology reveals >20% blasts. Flow cytometry identifies the blasts as CD34+ and myeloperoxidase positive. The veterinarian suspects acute myeloid leukemia (AML). Which additional finding would be MOST consistent with AML in this case?

A canine patient is suspected of having lymphoma. The veterinarian performs a fine needle aspirate of an enlarged lymph node. Cytological evaluation reveals a homogeneous population of large lymphocytes. How can the veterinarain confirm diagnosis?

Which of the following findings on a complete blood count (CBC) would MOST strongly suggest aleukemic leukemia?

A veterinary professional is reviewing the medical history of a dog diagnosed with lymphoma. The dog initially responded well to chemotherapy but is now experiencing a relapse. The veterinarian notes that the referring veterinarian used single-agent steroid therapy prior to starting chemotherapy. What is the MOST important consideration in this case?

What is the primary difference between cyotologic and histologic evaluation?

While performing a routine CBC, a veterinary technician notices the presence of large atypical cells in the blood smear of a 6-year-old mixed breed dog. Which follow-up test would be most useful in determining prognosis?

Which of the following is a characteristic of multiple myeloma?

When diagnosing multiple myeloma, which result indicates the disease?

What process is used to divide proteins according to different electrical charges?

What can a veterinary technician expect with a dog with canine AML?

An incidental finding of elevated white blood cells is seen on a CBC for a 10 year old dog. What should a veterinary thchnician consider?

What should a veterinary technician look for on a blood smear to diagnose leukemia?

A blood sample is collected from a veterinary patient with suspected multiple myeloma, a monoclonal gammopathy is noted, which is?

An animal presents that is suspected to have a hematopoietic neoplasia, where do they originate?

What is the typical age range for dogs diagnosed with lymphoma?

Which of the following is a common anatomical site for lymphoma development?

Which of the following characteristics distinguishes lymphoma from solid tissue tumors?

In the histological diagnosis of lymphoma, what key feature is examined to assess tissue architecture?

What cytological finding is MOST indicative of lymphoma?

What is a common, but not consistent, finding on a CBC in animals with lymphoma?

What is the MOST common cause of hypercalcemia in dogs with T-cell lymphoma?

Which diagnostic method is LEAST likely to be employed to classify lymphoma by location?

Which anatomical location is characteristic of alimentary lymphoma in older cats?

What does the suffix 'b' appended to the stage of multicentric lymphoma generally indicate?

What sample types can be used for PARR (PCR for Antigen Receptor Rearrangement)?

Which diagnostic tool is most suited to determine if a patient has lymphoma and has high sensivity?

When classifying lymphoma based on histology, what information does it convey?

What microscopic characteristic differentiates indolent lymphoma from high-grade lymphoma?

Which of the following is characteristic of indolent T-zone lymphoma?

According to prognostic factors, what is the expected outcome for a patient with I/II staged B cell lymphoma?

Which parameter is most crucial to determine if it's acute leukemia?

Why are cytopenias commonly seen in acute leukemia?

In general terms, in what age distribution is acute leukemia seen?

Which of the following accurately describes a key feature in chronic leukemia?

Which of the following CBC findings is MOST indicative of chronic leukemia?

What is a significant risk for the animal with leukemia?

In a horse presenting with lymphocytosis detected incidentally, what follow-up test would MOST strongly suggest a neoplastic process?

Which characteristic is generally associated with paraproteins linked to multiple myeloma?

What is the role of determining monoclonal gammopathy as a diagnostic criteria for multiple myeloma?

What is the MOST important finding on protein electrophoresis that is suggestive of multiple myeloma?

Greater than what percentage of plasma cells of the bone marrow composition would suggest myeloma?

Which of the following is a common finding in animals with multiple myeloma?

What is the underlying cause of peripheral cytopenias in multiple myeloma?

What is known about the nature of Histiocytic disorders?

Which of the following features is MOST characteristic of histiocytic sarcoma cells?

When staging multicentric lymphoma, a dog with liver and spleen involvement, but appearing clinically normal, would be classified as which stage?

A presumptive diagnosis of acute leukemia has been made based on initial bloodwork, and there is a need to differentiate between ALL and AML. Which of the following tests should be performed NEXT?

In the context of hematopoietic neoplasia, what differentiates 'leukemia' from 'leukemic'?

What is the MOST critical implication of single-agent steroid therapy used prior to chemotherapy in canine lymphoma?

In cases of suspected lymphoma, how do cytologic and histologic evaluations primarily differ?

A dog presents with a mildly elevated white blood cell count found incidentally. What follow-up test would be MOST relevant to assess the underlying cause and rule out neoplasia?

What is the MAIN principle behind protein electrophoresis?

A veterinary technician is assisting in the diagnosis of a dog with suspected acute myeloid leukemia (AML). Based on the information provided, which of the following clinical signs and lab findings would the technician LEAST expect to observe?

An animal is suspected to have a hematopoietic neoplasia, where are these cell types derived from?

Which of the following would be considered an indication of aleukemic leukemia?

A veterinary technician reviews the results of a complete blood count (CBC) and notes that a canine patient has a PCV of 34% (low), WBC 8,000 (normal), Neutrophils of 7,200/uL (normal), and 560/uL Lymphocytes (low). What can be concluded?

Based on Molly's CBC, with PCV of 34% (low), WBC normal, Neutrophils Normal and Lymphocytes (low) what is a possible diagnosis?

Gertie presents with physical exam within normal limits, 30% PCV (low), Retic 24,640/uL (low), high WBC and blasts on a CBC. What diagnosis is most consistent?

A veterinarian suspects that Gertie has is it ALL or AML, what special stain can you use to determine the difference?

Which cell type serves as the origin for multiple myeloma?

In the classification of leukemia, what lineages are encompassed within the 'myeloid' designation?

Which characteristic distinguishes acute from chronic leukemia?

What is the MOST common presenting sign in animals with lymphoma?

Lymphoma is least likely to be found at which anatomical site?

When diagnosing lymphoma, what cellular feature is MOST indicative of the condition on a cytology sample?

What finding on a complete blood count (CBC) is LEAST likely in an animal with lymphoma?

Some types of lymphoma can cause unexplained hypercalcemia. What is the underlying cause?

What does a 'spike' formation indicate when interpreting the results of PCR for Antigen Receptor Rearrangement (PARR)?

What is a potential consequence of administering steroids to a canine lymphoma patient prior to initiating chemotherapy?

Histologically, how are high-grade lymphomas characterized?

What is generally the best prognostic indicator in dogs with lymphoma?

In contrast to lymphoma involving a mass, what CBC abnormalities are most suggestive of acute leukemia?

What diagnostic test is MOST appropriate to differentiate between ALL and AML?

What is the BEST approach to accurately diagnose chronic lymphocytic leukemia (CLL)?

If a veterinary professional suspects multiple myeloma, what confirmatory diagnostic test should be run?

In serum protein electrophoresis, what finding is MOST suggestive of multiple myeloma?

What is the primary method by which histiocytic sarcoma can cause anemia?

Animals with a high percentage of immature precursors, should probably have how many blasts?

Which of the following factors plays a role in deciding what should be done based on what multiple myeloma costs?

What is the MOST likely diagnosis for a horse with approximately 18,000 lymphocytes that are small? There are no clinical signs.

Which feature is LEAST associated with non-indolent lymphomas?

Which of the following is NOT a primary location to look for lymphoma?

What is the MOST specific application of flow cytometry in characterizing lymphoma beyond PARR?

Which of the diagnostic results is NOT typically associated with multiple myeloma?

How does the terminology 'leukemic' differ from 'leukemia' in the context of hematopoietic neoplasia?

Which strategy is LEAST helpful to differentiate between lymphoma and acute leukemia?

Which combination of diagnostic findings would MOST strongly suggest a diagnosis of multiple myeloma?

You are reviewing a CBC of Gertie and you are thinking it could be either ALL or AML, and are trying to stain to differentiate. What special stain can you use?

Which patient is MOST likely to present with cutaneous lymphoma?

Which of the following is stage IV lymphoma?

When seeing many small lymphocytes, what cell type do we have a neoplasm?

Dogs with what cell type tumors will often do better than the others?

Which of the following is the most common lymphoma in the cat?

What is the source of the term multiple in 'multiple myeloma'?

What is the purpose of serum protein electrophoresis?

If an animal is not feeling well and has leukemia, where is this arising from?

When diagnosing myeloma, how many of the symptoms do they need?

What is the appropriate amount of cells needed for PARR results?

A case should be looked at and interpreted in context, which is?

Immunophenotyping using flow cytometry identifies cells with specific markers. What are these cells?

If all the lymphocytes from T cells have one rearrangement, what cells do we have?

What sample is needed for a flow test?

Which of the following cell types is NOT considered a precursor for myeloid leukemia?

What is the primary distinguishing characteristic of acute leukemia compared to chronic leukemia?

In which animal species is lymphoma considered the most common malignant tumor?

Which of the following is the MOST typical initial clinical sign in an animal with lymphoma?

What does 'effacement of normal architecture' in a lymph node biopsy MOST strongly suggest?

A dog with lymphoma is described as 'Stage III'. According to the staging system discussed, what does this indicate?

What is the primary purpose of PCR for Antigen Receptor Rearrangement (PARR) in diagnosing lymphoma?

What finding on a PARR test is MOST indicative of a neoplastic lymphoid population?

Which of the following is a common cell surface marker used to identify B-cells in immunophenotyping of lymphoma?

What is the clinical significance of CD34 positivity in hematopoietic neoplasia?

Which histologic feature is typically associated with high-grade lymphomas?

Indolent lymphomas are characterized by which of the following?

Which subtype of indolent lymphoma is characterized by 'inside-out' follicles and CD21 positivity?

What is a potential negative consequence of using single-agent steroids to treat canine lymphoma prior to chemotherapy?

In acute leukemia, what percentage of blasts in the bone marrow is generally considered diagnostic?

Which of the following is a typical Complete Blood Count (CBC) finding in acute leukemia?

What is 'myelopthesis' in the context of leukemia?

Which of the following best describes chronic leukemia?

In a horse with incidental lymphocytosis and no clinical signs, which follow-up test would be MOST helpful to differentiate between reactive lymphocytosis and chronic lymphocytic leukemia (CLL)?

What is the primary cell type involved in multiple myeloma?

Which diagnostic finding is MOST suggestive of multiple myeloma?

What are Bence Jones proteins in the context of multiple myeloma?

Lytic bone lesions and hypercalcemia are clinical signs associated with multiple myeloma. What is the underlying mechanism for these findings?

Histiocytic sarcoma originates from which cell type?

Erythrophagia, the engulfment of red blood cells, is a characteristic feature associated with which neoplasm?

Which of the following best describes the difference between 'leukemia' and 'leukemic' in the context of hematopoietic neoplasia?

An animal presents with pancytopenia on CBC. Bone marrow cytology reveals a predominance of blast cells (>20%). Which of the following is the MOST likely broad diagnostic category?

When differentiating between Acute Lymphoid Leukemia (ALL) and Acute Myeloid Leukemia (AML), which diagnostic test would be MOST definitive?

Which of the following is LEAST likely to be a presenting clinical sign for chronic lymphocytic leukemia (CLL) in its early stages?

What is the MOST important factor to consider when interpreting atypical lymphocytes on a blood smear?

Which of the following is a characteristic feature of T-zone lymphoma?

An 8-year-old dog presents with PUPD and a chemistry panel reveals hypercalcemia. Which hematopoietic neoplasia should be a primary differential?

Which of the following techniques is MOST sensitive and provides the most detailed immunophenotypic information for lymphoma diagnosis?

If a dog is diagnosed with Stage IV lymphoma, what organ involvement is indicated?

What is the typical age distribution for animals diagnosed with acute leukemia?

In serum protein electrophoresis, which protein fraction is primarily composed of immunoglobulins (antibodies)?

For optimal results from PCR for Antigen Receptor Rearrangement (PARR), approximately how many cells are ideally needed?

Which of the following is the LEAST common anatomical location for lymphoma in dogs?

If immunophenotyping of a lymphoma reveals a CD4 positive T-cell phenotype, what is the prognostic implication compared to a B-cell lymphoma?

In veterinary medicine, the term 'lymphosarcoma' is considered:

Which of the following species is LEAST commonly affected by lymphoma?

In dogs, multicentric lymphoma is characterized by the involvement of:

What does a 'B' designation appended to the clinical stage of canine lymphoma indicate?

PCR for Antigen Receptor Rearrangement (PARR) primarily aids in lymphoma diagnosis by:

In the context of lymphoma, 'effacement of normal architecture' in a lymph node biopsy refers to:

A key feature distinguishing acute leukemia from chronic leukemia is:

Myelopthesis, a common consequence of leukemia, directly leads to:

In serum protein electrophoresis, a monoclonal gammopathy is MOST suggestive of:

Histiocytic sarcoma is characterized by neoplastic proliferation of:

Which of the following is LEAST likely to be a typical Complete Blood Count (CBC) finding in an animal with lymphoma?

What is the primary rationale for avoiding single-agent steroid therapy prior to initiating chemotherapy in canine lymphoma?

In cases of suspected aleukemic leukemia, which diagnostic approach is MOST critical for diagnosis?

The presence of CD34 positivity in hematopoietic neoplasia is most indicative of:

T-zone lymphoma, an indolent subtype, is characterized by neoplastic cells that are typically:

Erythrophagia, the engulfment of red blood cells by neoplastic cells, is a characteristic feature most strongly associated with:

Which combination of diagnostic findings would be MOST definitively indicative of multiple myeloma?

To differentiate between Acute Lymphoblastic Leukemia (ALL) and Acute Myeloid Leukemia (AML) when blast morphology is inconclusive, which ancillary diagnostic test is MOST definitive?

A horse presents with an incidental finding of lymphocytosis (18,000 lymphocytes/µL) comprised of small, normal-appearing lymphocytes, and is clinically normal. PARR analysis reveals a monoclonal T-cell receptor gene rearrangement. What is the MOST likely diagnosis?

An 8-year-old Labrador Retriever presents with fever, moderate leukocytosis, atypical mononuclear cells, and moderate thrombocytopenia. Bone marrow cytology reveals >20% blasts. Flow cytometry identifies the blasts as CD34+ and myeloperoxidase positive. Which additional finding would be MOST consistent with Acute Myeloid Leukemia (AML) in this case?