Malignant Lymphomas and Leukemia Features

Questions and Answers

Which of the following are features of lymphoma? (Select all that apply)

Solid cohesive neoplasm (correct)

Mostly originate from epithelial tissue

Not cohesive

Lose their adhesive property by mutation (correct)

What is a characteristic of leukemia?

Cohesive structure

Increased WBC count in serum (correct)

Always originates from lymphoid tissue

Solid mass formation restricted to lymphoid tissue

What defines lymphoma according to the WHO classification?

Morphology, Cell origin, Clinical features, Genotype

Classification of lymphoma can be categorized into three groups: Tumor of B, Tumor of T & NK, and ______.

<p>Hodgkin Lymphomas</p> Signup and view all the answers

Match the types of lymphoma with their characteristics:

<p>Precursor B neoplasm = B-cell ALL Peripheral B neoplasm = Mantle cell lymphoma Precursor T neoplasm = T-cell ALL Peripheral NK neoplasm = NK cell leukemia</p> Signup and view all the answers

Study Notes

Lymphoma Overview

Lymphomas are solid, cohesive neoplasms primarily originating from lymphoid tissue.
They can mutate and lose their adhesive properties, potentially leading to a leukemic phase.

Leukemia Characteristics

Leukemia is a malignancy of hematopoietic precursor cells, transitioning from bone marrow to circulation.
Unlike lymphomas, leukemias are not cohesive, resulting in elevated white blood cell counts in serum.
Leukemia can develop solid masses in lymphoid tissues, resembling lymphoma.
Two main stem cell types give rise to leukemias:
- Myeloid stem cells lead to myeloid leukemia.
- Lymphoid stem cells result in lymphoid leukemia.

WHO Classification of Lymphomas

The World Health Organization classifies lymphomas by:
- Morphological characteristics.
- Cell of origin.
- Clinical features observed in patients.
- Genotypic information of the lymphoma.

Categories of Lymphomas

Tumor of B Cells:
- Includes precursor B neoplasm (B-cell Acute Lymphoblastic Leukemia - ALL) and peripheral B neoplasms (Mantle cell lymphoma, Follicular lymphoma, Burkitt lymphoma).
Tumor of T and NK Cells:
- Comprises precursor T neoplasms (T-cell ALL) and peripheral NK neoplasms (NK cell leukemia, mycosis fungoides).
Hodgkin Lymphomas:
- Categorized into three grades:
  - Low grade: Small lymphocytic, follicular; generally poor prognosis.
  - Intermediate grade: Follicular, large cells, diffuse.
  - High grade: Large cell, immunoblastic, lymphoblastic; usually better prognosis.

Description

Explore the distinguishing features of malignant lymphomas and leukemia through this informative diagram. Understand their characteristics, differences, and origins in lymphoid and hematopoietic tissues. Test your knowledge about Hodgkin and Non-Hodgkin lymphomas.