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Questions and Answers
Which of the following are features of lymphoma? (Select all that apply)
Which of the following are features of lymphoma? (Select all that apply)
- Solid cohesive neoplasm (correct)
- Mostly originate from epithelial tissue
- Not cohesive
- Lose their adhesive property by mutation (correct)
What is a characteristic of leukemia?
What is a characteristic of leukemia?
- Cohesive structure
- Increased WBC count in serum (correct)
- Always originates from lymphoid tissue
- Solid mass formation restricted to lymphoid tissue
What defines lymphoma according to the WHO classification?
What defines lymphoma according to the WHO classification?
Morphology, Cell origin, Clinical features, Genotype
Classification of lymphoma can be categorized into three groups: Tumor of B, Tumor of T & NK, and ______.
Classification of lymphoma can be categorized into three groups: Tumor of B, Tumor of T & NK, and ______.
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Match the types of lymphoma with their characteristics:
Match the types of lymphoma with their characteristics:
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Study Notes
Lymphoma Overview
- Lymphomas are solid, cohesive neoplasms primarily originating from lymphoid tissue.
- They can mutate and lose their adhesive properties, potentially leading to a leukemic phase.
Leukemia Characteristics
- Leukemia is a malignancy of hematopoietic precursor cells, transitioning from bone marrow to circulation.
- Unlike lymphomas, leukemias are not cohesive, resulting in elevated white blood cell counts in serum.
- Leukemia can develop solid masses in lymphoid tissues, resembling lymphoma.
- Two main stem cell types give rise to leukemias:
- Myeloid stem cells lead to myeloid leukemia.
- Lymphoid stem cells result in lymphoid leukemia.
WHO Classification of Lymphomas
- The World Health Organization classifies lymphomas by:
- Morphological characteristics.
- Cell of origin.
- Clinical features observed in patients.
- Genotypic information of the lymphoma.
Categories of Lymphomas
-
Tumor of B Cells:
- Includes precursor B neoplasm (B-cell Acute Lymphoblastic Leukemia - ALL) and peripheral B neoplasms (Mantle cell lymphoma, Follicular lymphoma, Burkitt lymphoma).
-
Tumor of T and NK Cells:
- Comprises precursor T neoplasms (T-cell ALL) and peripheral NK neoplasms (NK cell leukemia, mycosis fungoides).
-
Hodgkin Lymphomas:
- Categorized into three grades:
- Low grade: Small lymphocytic, follicular; generally poor prognosis.
- Intermediate grade: Follicular, large cells, diffuse.
- High grade: Large cell, immunoblastic, lymphoblastic; usually better prognosis.
- Categorized into three grades:
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