Hematology Quiz: Anemia and Blood Disorders

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Questions and Answers

Which of the following conditions would not lead to a decreased erythrocyte count?

  • Pregnancy
  • Chronic hypoxia (correct)
  • Hemorrhage
  • Myelofibrosis

What is the most common cause of microcytic anemia?

  • Folate deficiency
  • Iron deficiency (correct)
  • Vitamin B12 deficiency
  • Aplastic anemia

What is the defining characteristic of macrocytic anemia?

  • Deficiency of all blood cell types
  • Small, pale red blood cells
  • Large, immature red blood cells (correct)
  • Increased production of red blood cells

Which of the following is a physiological cause of polycythemia?

<p>Living at high altitudes (D)</p> Signup and view all the answers

What is the typical cause of aplastic anemia?

<p>Toxin exposure, hereditary, or autoimmune disorder (A)</p> Signup and view all the answers

What is the main function of the segmented neutrophil?

<p>To engulf and destroy bacteria. (C)</p> Signup and view all the answers

What is the reticulocyte count used for?

<p>To determine the rate of red blood cell production. (A)</p> Signup and view all the answers

Which of the following is NOT a component of a complete blood count (CBC)?

<p>Blood urea nitrogen (BUN) (C)</p> Signup and view all the answers

What is the difference between Hodgkin’s lymphoma and non-Hodgkin’s lymphoma?

<p>Hodgkin's lymphoma is characterized by the presence of Reed-Sternberg cells, while non-Hodgkin's lymphoma is not. (C)</p> Signup and view all the answers

What is the mean corpuscular volume (MCV)?

<p>The average size of a red blood cell. (C)</p> Signup and view all the answers

If a patient has iron deficiency anemia, what would you expect about their MCV and RDW?

<p>MCV would be decreased, RDW would be increased (D)</p> Signup and view all the answers

Which of the following is NOT a potential cause of leukocytosis?

<p>Bone marrow failure (A)</p> Signup and view all the answers

What is the average concentration of hemoglobin in a red blood cell relative to its volume called?

<p>Mean corpuscular hemoglobin concentration (MCHC) (A)</p> Signup and view all the answers

Which of the following is NOT a potential cause of leukopenia?

<p>Inflammation (A)</p> Signup and view all the answers

What type of anemia is characterized by a decreased MCV and increased RDW?

<p>Iron deficiency anemia (A)</p> Signup and view all the answers

A reticulocyte count of 0.2% in a patient with anemia suggests which of the following?

<p>The patient is likely experiencing a bone marrow failure. (D)</p> Signup and view all the answers

What is the primary difference between a low hematocrit (Hct) due to dehydration and a low Hct due to anemia?

<p>Dehydration will primarily affect the plasma volume, while anemia affects the number of red blood cells. (D)</p> Signup and view all the answers

Which of the following conditions is MOST LIKELY to present with an increased Mean Platelet Volume (MPV)?

<p>Massive hemorrhage (C)</p> Signup and view all the answers

A patient presents with a low platelet count (thrombocytopenia). Which of the following is NOT a possible cause?

<p>Iron deficiency anemia (A)</p> Signup and view all the answers

Which red blood cell (RBC) index measures the average volume of a single RBC?

<p>MCV (B)</p> Signup and view all the answers

What is the significance of a high reticulocyte count in a patient with anemia?

<p>It implies the bone marrow is actively producing more red blood cells. (A)</p> Signup and view all the answers

Which of the following conditions is most likely to cause a low hematocrit (Hct)?

<p>Iron deficiency anemia (D)</p> Signup and view all the answers

Which of the following is NOT a characteristic of a reticulocyte?

<p>Larger than a mature red blood cell (B)</p> Signup and view all the answers

Which of the following is NOT a characteristic of Reed-Sternberg cells, found in Hodgkin's lymphoma?

<p>Increased number of red blood cells (C)</p> Signup and view all the answers

Which of the following conditions is NOT associated with an increase in serum ferritin levels?

<p>Iron deficiency anemia (D)</p> Signup and view all the answers

A patient presents with a low transferrin saturation level. What is the most likely explanation for this?

<p>Iron deficiency anemia (C)</p> Signup and view all the answers

What is the primary function of transferrin in the body?

<p>Transport of iron (A)</p> Signup and view all the answers

Which of the following is the MOST accurate statement regarding the erythrocyte sedimentation rate (ESR)?

<p>ESR is a nonspecific test for inflammation. (D)</p> Signup and view all the answers

What is the main difference between ESR and C-reactive protein (CRP) in terms of their sensitivity to inflammation?

<p>CRP is generally more sensitive to inflammation and responds more quickly than ESR (A)</p> Signup and view all the answers

Which of the following is NOT a common cause of an elevated C-reactive protein (CRP) level?

<p>Viral infection (C)</p> Signup and view all the answers

Which of the following tests is NOT typically included in a coagulation panel?

<p>Creatinine kinase (CK) (C)</p> Signup and view all the answers

Which of the following conditions would MOST likely result in an increase in bleeding time?

<p>Platelet deficiency (B)</p> Signup and view all the answers

What is the primary goal of a coagulation panel?

<p>To assess the body's ability to form blood clots (B)</p> Signup and view all the answers

What is a "left shift" in a white blood cell differential?

<p>An increase in immature neutrophils (bands), indicating an ongoing bacterial infection. (B)</p> Signup and view all the answers

What type of cell is most likely to increase during a parasitic infection?

<p>Eosinophils (B)</p> Signup and view all the answers

Which of the following is a characteristic of chronic lymphocytic leukemia (CLL)?

<p>Elevated white blood cell count with an asymptomatic presentation. (D)</p> Signup and view all the answers

A blood smear is often ordered when a CBC detects abnormal values. What is the purpose of a blood smear?

<p>To assess the size, shape, and structure of blood cells. (C)</p> Signup and view all the answers

What is the significance of Dohle bodies in a blood smear?

<p>They indicate severe stress or trauma. (C)</p> Signup and view all the answers

Which of the following is a hallmark feature of acute leukemia?

<p>Presence of blast cells. (C)</p> Signup and view all the answers

What is the key difference between acute and chronic leukemia?

<p>Acute leukemia is more common in children, while chronic leukemia is more common in adults. (C)</p> Signup and view all the answers

Which of the following statements about lymphomas is TRUE?

<p>Lymphomas are cancers of the lymphatic system. (A)</p> Signup and view all the answers

What is the significance of a white blood cell differential?

<p>It determines the proportion of different types of white blood cells in the blood. (B)</p> Signup and view all the answers

Flashcards

CBC Components

A series of tests providing information about RBCs, WBCs, and platelets.

RBC Indices

Measurements of red blood cells, including MCV, MCH, and MCHC.

Anemia Causes

Conditions leading to decreased red blood cells or hemoglobin levels.

Ferritin vs Iron

Ferritin stores iron; both indicate iron status in the body.

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White Blood Cell Types

Includes neutrophils, lymphocytes, monocytes, eosinophils, and basophils; each with specific functions.

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Erythrocyte count

The number of RBCs in 1mm3 of peripheral blood, with reference ranges being 4.7 – 6.1 (male) and 4.2 – 5.4 (female) x10^12/L.

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Anemia

A condition characterized by decreased RBC count, indicating insufficient oxygen transport in the blood.

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Macrocytic anemia

A type of anemia where large, immature RBCs are produced due to impaired DNA synthesis, commonly from Vit B12 or folate deficiency.

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Microcytic anemia

A condition with small RBCs, often due to iron deficiency, leading to inadequate oxygen transport.

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Pancytopenia

A deficiency of all blood cell types (RBCs, WBCs, platelets), often caused by aplastic anemia.

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MCV (Mean Corpuscular Volume)

Indicates the size of red blood cells; used in anemia classification.

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Megaloblastic Anemias

Anemias caused by B12 or folic acid deficiency; characterized by increased MCV.

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RDW (Red Blood Cell Distribution Width)

Measures the variation in RBC sizes; aids in classifying anemias.

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WBC Count

Number of white blood cells in a blood sample; normal range is 5,000-10,000/mm3.

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Leukocytosis

Increase in WBC count; commonly points to infection or inflammation.

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Reticulocytes

Immature red blood cells indicating bone marrow activity.

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Retic Count Reference Range

Normal range for reticulocytes in adults is 0.5% - 2.0%.

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Increased Retic Count

Indicates the marrow is producing more RBCs due to loss.

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Low Retic Count in Anemia

Suggests inadequate bone marrow response in anemic patients.

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Hemoglobin (Hgb)

Protein in RBCs that carries oxygen; reference range for males is 14-18 g/dL, for females is 12-16 g/dL.

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Hematocrit (Hct)

Percentage of blood volume made up of RBCs; male reference: 42-52%, female: 37-47%.

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Platelet Count (Plt)

Number of platelets per cubic mm; normal range is 150,000-400,000/mm3.

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Mean Corpuscular Volume (MCV)

Average size of red blood cells; important in classifying RBC size abnormalities.

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Left Shift

An increase in immature neutrophils (bands) indicating bacterial infection.

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Right Shift

A return to normal neutrophil counts from a left shift, indicating recovery or stabilization.

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Neutrophilia without Bands

An increase in neutrophils without immature forms, possibly indicating inflammation without infection.

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Lymphocyte Percentage

Lymphocytes constitute 20-40% of WBCs, involved in chronic bacterial or acute viral infections.

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Hypersegmented Neutrophils

Neutrophils with 6 or more lobes, sensitive to megaloblastic anemias (B12/folic acid deficiency).

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Leukemia

WBC cancer classified into acute (immature WBCs) and chronic (mature WBCs), both with high WBC counts.

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Auer Rods

Structures found in acute myeloid leukemia (AML), indicating a specific type of cancer.

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Lymphomas

Cancers originating from lymphocytes, with various subtypes and presentations.

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Hodgkin’s lymphoma (HL)

A type of cancer marked by Reed-Sternberg cells; 10% of lymphoma cases.

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Non-Hodgkin’s lymphoma (NHL)

A type of lymphoma accounting for 90% of cases; varied forms without Reed-Sternberg cells.

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Iron Panel Components

Serum iron, TIBC, transferrin saturation, ferritin; assesses iron levels in the body.

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Serum Iron

Iron found in hemoglobin; 70% in RBCs, 30% stored as ferritin.

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Total Iron Binding Capacity (TIBC)

Measure of proteins available to bind iron, primarily transferrin.

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Transferrin Saturation

Percentage of TIBC that is saturated with iron; indicates body's iron status.

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Ferritin

Major storage protein for iron; low levels indicate deficiency, high levels indicate excess.

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Erythrocyte Sedimentation Rate (ESR)

Rate at which RBCs settle; increased in inflammation or infection.

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C-reactive Protein (CRP)

Acute phase reactant protein indicating inflammation; responds quickly to changes.

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Coagulation Panel Tests

Includes bleeding time, PT/INR, PTT; assesses hemostatic function.

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Study Notes

Hematology Week 3

  • The course covers hematology, focusing on blood components and conditions.
  • Instructional objectives include inventorying complete blood count (CBC) components, comparing anemia and polycythemia causes, debating reticulocyte count importance, contrasting iron-related elements and their indications, examining B12, folate and megaloblastic anemia relationship, inventorying blood cell functions and irregularities, contrasting lymphomas, and comparing different blood cancers.

Blood Components

  • CBC: A series of blood tests providing information about red blood cells (RBCs), platelets, and white blood cells (WBCs). Easy, quick, and inexpensive.
  • RBCs: Hemoglobin, hematocrit, RBC indices (MCV, MCH, MCHC, and RDW), and erythrocyte count.
  • WBCs: White blood cell count and differential of neutrophils, lymphocytes, monocytes, eosinophils, and basophils.
  • Platelets: Essential for blood clotting. Measured by platelet count.

Blood Cell Indices

  • MCV: The average size of red blood cells.
  • MCH: The average amount of hemoglobin in a red blood cell.
  • MCHC: The average concentration of hemoglobin in a red blood cell.
  • RDW: The variation in red blood cell sizes in a sample. Usually used in classifying anemias.
  • MPV: The average size of platelets.

Anemias

  • Macrocytic anemia: Megaloblastic anemia, DNA synthesis impairment during RBC production.
  • Microcytic anemia: Insufficient iron intake, increased need, insufficient absorption, or increased blood loss, iron deficiency, etc. Characterized by small red blood cells.
  • Causes of anemia: Decrease in RBC production by bone marrow, conditions that cause loss of red blood cells, and dilution of fluids in the body.

Other blood conditions

  • Polycythemia: Increased RBC count. Physiologically induced due to increased oxygen requirements or chronic hypoxia. Dehydration can artificially increase RBCs.
  • Leukemia: Cancer arising in the blood. Divided into acute and chronic types.
  • Lymphomas: Cancers from lymphocytes. Two main categories: Non-Hodgkin's lymphoma (NHL) and Hodgkin's lymphoma (HL).
  • Reticulocytes: Immature red blood cells, increased levels indicate high red blood cell production (e.g. trying to correct another condition) or blood loss.
  • Hemoglobin (Hgb): RBC protein for oxygen transport. Lower hemoglobin represents possible anemia.

Blood Tests Associated with Hematologic Conditions

  • Iron Panel: Serum iron, TIBC/transferrin, transferrin saturation, and ferritin. Measures iron levels, capacity, and storage.
  • ESR (Erythrocyte Sedimentation Rate): Measures how quickly red blood cells settle. Elevated in inflammatory conditions.
  • CRP (C-reactive protein): Acute-phase reactant indicating inflammation or infection. More sensitive than ESR.
  • Coagulation Panel: Tests measure efficiency and speed of blood clotting. Includes bleeding time, protime/prothrombin time (PT), PT/INR, partial thromboplastin time (PTT), and fibrinogen.
  • D-dimer: Indicates clot degradation, elevated suggests thrombosis.

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