Hematology Overview Quiz
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Questions and Answers

A patient presents with fatigue, pallor, and shortness of breath. Based on the provided definitions alone, what condition is primarily indicated?

  • Erythrocytopenia (correct)
  • Leukemoid Reaction
  • Leukemia
  • Thrombocytopenia

Which of the following is NOT a typical manifestation associated with thrombocyte dysfunction?

  • Epistaxis
  • Spontaneous gingival bleeding
  • Petechial hemorrhages
  • Oral candidiasis (correct)

A patient exhibits oral ulcerations with a pale, grayish-white necrotic base, along with frequent viral infections. Which cellular issue is MOST likely underlying these findings?

  • Erythrocyte deficiency
  • Leukocyte abnormality (correct)
  • Thrombocyte excess
  • Leukemoid reaction

In the context of leukemia, the presence of poorly differentiated leukemic cells in which locations is typically required for a diagnosis?

<p>Both peripheral blood and bone marrow (B)</p> Signup and view all the answers

In which specific condition are leukemic cells exclusively found in the bone marrow and not typically in peripheral blood?

<p>Acute Lymphoblastic Leukemia (ALL) (B)</p> Signup and view all the answers

A patient presents with a white blood cell count of 15,000/mL. Which of the following conditions is most likely?

<p>Pathogenic leukocytosis from an infection (D)</p> Signup and view all the answers

Which of the following is NOT typically a cause of leukocytosis?

<p>Chemotherapeutic drug use (C)</p> Signup and view all the answers

A patient's differential white blood cell count shows 15% lymphocytes, 65% neutrophils, 5% monocytes, 2% eosinophils, and 1% basophils could be indicative of:

<p>Leukocytosis with an elevated neutrophil count (C)</p> Signup and view all the answers

Which of the following best describes the relationship between pancytopenia and leukopenia?

<p>Pancytopenia often results from a similar cause as leukopenia (C)</p> Signup and view all the answers

A patient's blood test shows a WBC count of 3,000/mL, along with a differential count showing markedly reduced levels of neutrophils and monocytes. Which of the following conditions can best explain this result?

<p>Leukopenia manifesting as agranulocytosis (B)</p> Signup and view all the answers

Which characteristic is LEAST associated with Chronic Lymphocytic Leukemia (CLL)?

<p>Exhibiting a rapid proliferation of leukemic cells. (A)</p> Signup and view all the answers

A patient presents with a hallmark Philadelphia chromosome. Which condition is most likely the underlying cause?

<p>Chronic Myelogenous Leukemia (CML). (A)</p> Signup and view all the answers

What is a common systemic effect of Chronic Myelogenous Leukemia (CML) that also presents as a result of normal cell deficiencies?

<p>Oral and systemic lesions. (B)</p> Signup and view all the answers

During the progression of Chronic Myelogenous Leukemia (CML), what describes the shift in characteristics of the leukemic cells entering the blast crisis phase?

<p>The cells progress from having some non-function to being completely non-functional. (B)</p> Signup and view all the answers

Which of the following clinical presentations is LEAST likely to be associated with leukemic cell infiltration in CML?

<p>Painful ulcerations. (D)</p> Signup and view all the answers

Flashcards

Leukocytosis

An increase in the number of white blood cells (WBCs) circulating in the blood.

Leukopenia

A decrease in the number of white blood cells (WBCs) circulating in the blood.

Agranulocytosis

A severe reduction in the number of neutrophils, a type of white blood cell.

Pancytopenia

A decrease in all types of blood cells, including red blood cells, white blood cells, and platelets.

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Normal Differential WBC Count

The normal percentage of different types of white blood cells found in the blood.

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What is Leukemia?

Leukemia is a type of cancer that affects blood-forming tissues, primarily the bone marrow, resulting in the production of abnormal white blood cells (WBCs) that can't function properly.

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What is Acute Leukemia?

Acute Leukemia is a fast-growing type of leukemia that causes a rapid build-up of immature, non-functional WBCs in the bone marrow. Without treatment, it can be fatal within months.

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What is Chronic Leukemia?

Chronic Leukemia is a slower-growing type of leukemia that produces excessive numbers of more mature, but still abnormal, WBCs.

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What is AML?

Acute Myelogenous Leukemia (AML) is a type of acute leukemia that affects myeloid precursor cells in the bone marrow.

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What is ALL?

Acute Lymphocytic Leukemia (ALL) is a type of acute leukemia that affects immature lymphocytes in the bone marrow. It's the most common type in children and is very responsive to treatment.

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Leukemia

A type of blood cancer characterized by an abnormal increase in white blood cells, often neutrophils, leading to symptoms like mouth ulcers, pale necrotic base, and susceptibility to infections.

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Leukemoid Reaction

A condition where there's an increase in circulating white blood cells due to a stress response, not cancer.

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Acute Lymphoblastic Leukemia (ALL)

A type of leukemia characterized by the presence of leukemic cells only in the bone marrow, not in the blood.

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Erythrocyte Deficiency

Decreased red blood cell count causing fatigue, shortness of breath, and pale appearance.

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Thrombocyte Deficiency

Decreased platelet count leading to easy bruising and bleeding, often in the gums, nose, and palate.

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What is Chronic Lymphocytic Leukemia (CLL)?

A type of leukemia characterized by a gradual accumulation of mature B lymphocytes in the blood, bone marrow, and lymph nodes.

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What is Chronic Myelogenous Leukemia (CML)?

A type of leukemia that originates from immature myeloid white blood cells (WBCs), specifically the myeloblasts.

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What is the Philadelphia chromosome?

A unique chromosomal abnormality found in about 90% of CML cases, where genetic material from chromosomes 22 and 9 is exchanged.

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What is blast crisis in CML?

The phase of CML where leukemic cells lose function and the disease progresses rapidly. This stage is characterized by a high number of blast cells in the bone marrow and blood.

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What is the chronic phase of CML?

The phase of CML where leukemic cells proliferate slowly, but are still abnormal and not functional.

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