Hematology 2: Principle of Coagulation

<p>Fibrinogen conversion to fibrin (C)</p> Signup and view all the answers

<p>Converts fibrinogen to fibrin (D)</p> Signup and view all the answers

<p>Factor VII (D)</p> Signup and view all the answers

<p>Platelet aggregation is initiated by the binding of fibrinogen to platelet receptors GPIIb/GPIIa. (B)</p> Signup and view all the answers

<p>Factor VII (B)</p> Signup and view all the answers

<p>Red blood cells (A)</p> Signup and view all the answers

<p>Stabilizes the fibrin clot (C)</p> Signup and view all the answers

<p>Primary hemostasis (D)</p> Signup and view all the answers

<p>Plasma proteins (A)</p> Signup and view all the answers

<p>Dissolves the fibrin clot (A)</p> Signup and view all the answers

<p>It reduces blood loss and facilitates platelet adhesion (A)</p> Signup and view all the answers

<p>It initiates the extrinsic coagulation pathway (A)</p> Signup and view all the answers

<p>Primary hemostasis precedes secondary hemostasis (B)</p> Signup and view all the answers

<p>To provide a barrier between blood and the surrounding tissues (A)</p> Signup and view all the answers

<p>Coagulation factors (A)</p> Signup and view all the answers

<p>To form the framework of a stable blood clot (D)</p> Signup and view all the answers

<p>Vascular media (C)</p> Signup and view all the answers

<p>Regulation of blood pressure (C)</p> Signup and view all the answers

<p>It provides structural support and anchors the blood vessel to surrounding tissues. (D)</p> Signup and view all the answers

<p>Fibrinolysis is a pathway that occurs after secondary hemostasis to dissolve the clot. (D)</p> Signup and view all the answers

<p>It is the site where platelet adhesion, aggregation, and clot formation primarily occur. (B)</p> Signup and view all the answers

<p>They directly produce red blood cells and platelets. (B)</p> Signup and view all the answers

<p>Inflammation increases vascular permeability to allow immune cells and fluids to reach the affected area. (D)</p> Signup and view all the answers

<p>Inflammation constricts the injured vessel, reducing blood flow. (C)</p> Signup and view all the answers

<p>Platelets provide a surface for the coagulation reaction and form a stable clot with fibrin. (D)</p> Signup and view all the answers

<p>Normal ECM helps maintain a normal blood flow by suppressing hemostasis. (C)</p> Signup and view all the answers

<p>Directly breaking down fibrin clots to prevent excessive clotting. (A)</p> Signup and view all the answers

<p>Calcium acts as a catalyst for the formation of thrombin. (C)</p> Signup and view all the answers

<p>Platelets have receptors that bind to fibrin, creating a stable platelet-fibrin clot. (A)</p> Signup and view all the answers

<p>Coagulation is a complex process involving plasma proteins, tissue factors, and calcium. (B)</p> Signup and view all the answers

<p>To minimize further bleeding and facilitate clot formation. (D)</p> Signup and view all the answers

<p>Inhibits platelet activation (A)</p> Signup and view all the answers

<p>Nitric oxide (C)</p> Signup and view all the answers

<p>Linking arterial and venous circulation (A)</p> Signup and view all the answers

<p>The hemostatic system's balance (D)</p> Signup and view all the answers

<p>Thin walls, most numerous, anchored with collagen (A)</p> Signup and view all the answers

<p>Insufficient blood clotting (B)</p> Signup and view all the answers

<p>They inhibit platelet aggregation (D)</p> Signup and view all the answers

<p>Veins (C)</p> Signup and view all the answers

<p>Deliver oxygenated blood away from the heart (A)</p> Signup and view all the answers

<p>Tunica media (D)</p> Signup and view all the answers

<p>Hypocoagulation (A)</p> Signup and view all the answers

<p>Thrombosis (A)</p> Signup and view all the answers

<p>Venules (A)</p> Signup and view all the answers

<p>Too much platelet production (A)</p> Signup and view all the answers

<p>To control blood flow by contraction and dilation (A)</p> Signup and view all the answers

<p>Factors are mostly produced in the liver (C)</p> Signup and view all the answers

The process that prevents excessive bleeding and forms a stable blood clot.

The physiological process that stops bleeding while maintaining blood flow.

The initial attachment of platelets to the site of vascular injury via GPIb and vWF.

The clumping together of platelets facilitated by GPIIb/GPIIa and fibrinogen.

Activation of coagulation factors leading to a cascade effect in clot formation.

The activated form of Stable factor (FVII), vital for blood coagulation.

Activated form of Prothrombin, known as Thrombin, crucial for converting fibrinogen to fibrin.

The two pathways that converge at Factor X a in the coagulation cascade.

Cells responsible for the formation of blood cells and their self-renewal.

The process that breaks down fibrin in blood clots, facilitating healing after injury.

Tissues surrounding blood vessels that are involved in hemostasis during injury.

Swelling and inflammation that limit blood loss and provide back-pressure on injured vessels.

Platelets interact with fibrin and form stable clots to prevent bleeding.

Proteins involved in blood clotting that require ionized calcium for activation.

Cytokines and tissue factors released by platelets that promote clot formation.

Inner layer of blood vessels; thin layer composed of endothelium.

Activated form of fibrinogen important for blood clotting.

Middle layer of blood vessels made of smooth muscles and elastic fibers.

Outer layer of blood vessels; strongest layer with collagen and elastic fibers.

Cells that line blood vessels; regulate immune response and permeability.

Ability of blood vessels to allow flow and transport of substances.

Formation of new blood vessels; crucial during healing and cancer.

The narrowing of blood vessels due to smooth muscle contraction, slowing down blood flow.

The initial response of the body to stop bleeding by forming a platelet plug.

The process that stabilizes the platelet plug via coagulation factors, creating a fibrin stable clot.

A protein that initiates the coagulation cascade when blood vessels are damaged.

A compound secreted by endothelial cells that inhibits platelet aggregation.

Blood vessels maintain balance between clotting and bleeding.

The smallest blood vessels that connect arteries to veins, responsible for microcirculation.

A state where the blood has a tendency to not clot effectively, leading to excessive bleeding.

A condition where there is an increased tendency for blood to clot, risking thrombosis.

Blood vessels that carry oxygenated blood away from the heart.

Blood vessels that carry deoxygenated blood back to the heart.

The innermost layer of a blood vessel, typically smooth to reduce friction.

The middle layer of a blood vessel, made of smooth muscle.

The outermost layer of a blood vessel that provides structural support.

Small blood vessels that branch from arteries and lead to capillaries.