Hematology 2 Lecture: Disorders of Hemostasis
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Questions and Answers

What is the most likely cause of deep tissue bleeding, such as hematomas or hemarthrosis, according to the text?

  • Platelet defect or vascular disorder
  • Massive transfusion of blood products
  • Physical trauma, such as obstruction
  • Plasma clotting factor deficiencies (correct)

Why does the pulse rate increase in trauma victims with significant blood loss?

  • To increase oxygen delivery to the tissues
  • To improve clotting and stop the bleeding
  • To compensate for the decrease in blood pressure (correct)
  • To induce a stress response and increase adrenaline

What is the definition of massive transfusion according to the text?

  • Administration of 10 to 12 RBC units within 24 hours
  • Administration of any amount of blood products to maintain blood pressure
  • Administration of 2 to 3 RBC units within 1 hour
  • Administration of 4 to 5 RBC units within 1 hour or 8 to 10 units within 24 hours (correct)

What is the relationship between the systolic blood pressure and the pulse rate in trauma victims with significant blood loss?

<p>The systolic blood pressure decreases while the pulse rate increases (D)</p> Signup and view all the answers

Which of the following is considered a superficial bleeding disorder according to the text?

<p>Epistaxis (nosebleed) (A)</p> Signup and view all the answers

What is the primary hemostatic defect that can lead to conditions like petechiae, epistaxis, or gingival bleeding?

<p>Platelet defect or vascular disorder (A)</p> Signup and view all the answers

What is the significance of epistaxis (nosebleed) lasting for more than 10 minutes and occurring repeatedly?

<p>It could be a sign of a problem with the patient's platelets or blood vessels (A)</p> Signup and view all the answers

What is the primary function of the increase in pulse rate observed in trauma victims with significant blood loss?

<p>To maintain blood pressure and perfusion (C)</p> Signup and view all the answers

Which type of bleeding disorder is typically associated with plasma clotting factor deficiencies?

<p>Deep tissue bleeding disorders (B)</p> Signup and view all the answers

What is the primary cause of the decrease in systolic blood pressure observed in trauma victims with significant blood loss?

<p>Loss of blood volume (B)</p> Signup and view all the answers

Flashcards

Petechiae

Pinpoint hemorrhagic spots in the skin, less than 2mm in size. Caused by the loss of capillary ability to withstand normal blood pressure and trauma. Indicates a problem with primary hemostasis.

Purpura

Hemorrhagic spots in the skin, approximately 3mm to 1cm in size. Caused by the loss of capillary ability to withstand normal blood pressure and trauma. Indicates a problem with primary hemostasis.

Ecchymosis

A bruise, larger than 1cm in size. A form of purpura where blood escapes into larger areas of skin and mucous membranes, but not into deep tissues. Indicates a problem with primary hemostasis.

Hematomas

Hemorrhage of blood into small areas of skin, mucous membranes, and other tissues, causing swelling. The suffix '-oma' indicates a benign swelling.

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Hemarthrosis

Leakage of blood into joint cavities. Indicates a problem with secondary hemostasis.

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Hematemesis

Vomiting of blood, typically from the upper digestive tract.

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Hematuria

The presence of red blood cells (RBCs) in the urine. Indicates a problem with secondary hemostasis.

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Hemoglobinuria

The presence of hemoglobin in the urine.

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Melena

Stool containing dark red or black blood, indicating bleeding from the upper gastrointestinal tract (esophagus, stomach, or small intestine).

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Hematochezia

Red stool, indicating bleeding from the lower gastrointestinal tract (colon or large intestine).

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Study Notes

Bleeding Disorders: Terminology and Clinical Findings

  • Petechiae: pinpoint hemorrhagic spots in the skin, size ≤ 2mm, caused by loss of capillary ability to withstand normal blood pressure and trauma, indicative of primary hemostasis problem.

  • Purpura: hemorrhagic spots in the skin, size ≈ 3mm (up to 1cm), purplish red, caused by loss of capillary ability to withstand normal blood pressure and trauma, indicative of primary hemostasis problem.

  • Ecchymosis: bruise, size > 1cm, form of purpura in which blood escapes into large areas of skin and mucous membranes, but not into deep tissues, indicative of primary hemostasis problem.

  • Hematomas: hemorrhage of blood into small areas of skin, mucous membranes, and other tissues, causing swelling, suffix "-oma" indicates benign swelling.

  • Hemarthrosis: leakage of blood into joint cavities.

  • Hematemesis: vomiting of blood.

  • Hematuria: presence of RBCs in urine.

  • Hemoglobinuria: presence of hemoglobin (Hgb) in urine.

  • Melena: stool containing dark red or black blood, indicating bleeding from upper GI tract (esophagus, stomach, or small intestine).

  • Hematochezia: red stool, indicating bleeding from lower GI tract (colon or large intestine).

  • Menorrhagia: excessive menstrual bleeding.

  • Hemoptysis: coughing out of blood.

  • Easy bruiseability: used to describe individuals with frequent and repeated occurrences of purpura and ecchymosis.

  • Coagulopathies: disorders of primary or secondary hemostasis that exhibit generalized bleeding or hemorrhage.

Clinical Manifestations of Bleeding Disorders

  • Superficial bleeding: petechiae, epistaxis (nosebleed), or gingival bleeding, usually associated with platelet defects or vascular disorders.

  • Deep tissue bleeding: hematomas or hemarthrosis, usually associated with plasma clotting factor deficiencies.

  • Massive transfusion: administration of 4 to 5 RBC units within 1 hour or 8 to 10 units within 24 hours, essential in healthy trauma victims when systolic blood pressure is less than 110 mm Hg, pulse is greater than 105 beats/min.

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Description

Learn about disorders of hemostasis in hematology during the Prelims Batch Mo 'Ko Iniwan lesson 4 on fibrinolysis. This lecture covers basic terminology for clinical findings in bleeding disorders, including petechiae and purpura.

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