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Disorders of the Blood Part 2: Approach to a Bleeding Child

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Disorders of the Blood Part 2: Approach to a Bleeding Child

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Questions and Answers

What is the main function of fibrinogen in the hemostatic process?

Providing the reaction surface on which clotting reactions occur

Acting as a ligand between platelets during platelet aggregation

Serving as a substrate for thrombin that forms the fibrin clot (correct)

Contracting to constrict and limit clot size

Which factor is measured in the intrinsic (surface activation) pathway of PT PTT tests?

Factor VII

Factor IX (correct)

Factor V

Factor X

What is the primary hemostatic mechanism associated with platelet plug formation in the hemostatic process?

Fibrin thrombus formation

Vasoconstriction

Extrinsic pathway

Platelet phase (correct)

What is the main function of platelets in the hemostatic process?

Forming the plug at the site of the vessel injury Signup and view all the answers

What is the purpose of the initial lab tests mentioned in the text?

To evaluate the clinical phenotype of bleeding Signup and view all the answers

What is a systematic approach for reaching a more precise clinical diagnosis when evaluating a child with a bleeding disorder?

Obtaining a complete history and physical examination Signup and view all the answers

Which coagulation assays measure the intrinsic and extrinsic pathways?

Activated Partial Thromboplastin Time and Prothrombin Time Tests Signup and view all the answers

What could be inferred from an initial screen showing increased PT and PTT with normal platelet count?

Vitamin K Deficiency or Liver Disease Signup and view all the answers

What is the normal range for Prothrombin Time Tests (PT) mentioned in the text?

10 to 16 seconds Signup and view all the answers

Which of the following is a helpful clinical feature in evaluating bleeding disorders, as per the text?

Menorrhagia Signup and view all the answers