Health Psychology 2 - January 2024

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Questions and Answers

What effect does food intake have on the homeostasis mechanism in the hypothalamus?

  • It influences the brainstem and hypothalamus. (correct)
  • It decreases the interaction between humoral and neural mechanisms.
  • It has no significant impact on gut health.
  • It exclusively activates neural processes.

What is associated with chronic stress in children regarding medication?

  • No change in reactivity of beta-2-adrenergic receptors.
  • Increase in beta-2-adrenergic receptor responsiveness.
  • Increase in activity of corticoid receptors.
  • Decrease activity in corticoid and beta-2-adrenergic receptors. (correct)

Which factor has a positive effect on high survival rates in HIV patients?

  • Increased physical activity levels.
  • Low positive affect.
  • High positive affect. (correct)
  • High negative affect.

What is the relationship between presence of someone else and dyspnea?

<p>More symptom-specific perception and less neural filtering. (C)</p> Signup and view all the answers

What hormone is found in sweat glands?

<p>Acetylcholine. (B)</p> Signup and view all the answers

Which of the following combinations is correct for the primary stress hormones?

<p>cortisol, epinephrine, norepinephrine (B)</p> Signup and view all the answers

What is the relationship between physical activity and the hippocampus according to Firth et al's experiment?

<p>Dominant link to the hippocampus involving age-related attenuation (D)</p> Signup and view all the answers

Which brain regions are associated with perseverative cognitions?

<p>Higher heart rate, higher cortisol, higher blood pressure and lower HRV (C)</p> Signup and view all the answers

What is the consequence of acute stress in laboratory studies?

<p>Parasympathetic route and change in ventilation (B)</p> Signup and view all the answers

What mechanism describes the gut-brain axis?

<p>Bidirectional interaction of afferent &amp; efferent systems with humoral and neural components (B)</p> Signup and view all the answers

Where do cytokine transporters primarily derive their pathway to reach the brain?

<p>Through the vagus nerve from cardiovascular organs (D)</p> Signup and view all the answers

What is the setpoint for happiness as indicated by determinants of happiness?

<p>50% setpoint; 40% intentional activity; 10% circumstances (C)</p> Signup and view all the answers

Which statement about the relay station of afferent and efferent nerves is correct?

<p>Ganglia serve as a relay station for these nerves (D)</p> Signup and view all the answers

What effect does social stress have on asthmatic patients' FeNO and cortisol levels?

<p>They increase and show more activity in MCC. (C)</p> Signup and view all the answers

How does the perception of dyspnea in asthma patients differ from that of healthy controls?

<p>Some asthma patients show higher and some lower activity compared to controls. (D)</p> Signup and view all the answers

What is the role of cortisol at target tissues?

<p>It enhances catecholamines synthesis at adrenal medulla and neurons. (A)</p> Signup and view all the answers

What is a consequence of sedentary behavior related to inflammatory markers?

<p>It increases inflammation markers and cannot be offset by physical activity. (B)</p> Signup and view all the answers

What effect does physical activity have on anxiety and depression in asthma patients?

<p>It decreases anxiety and depression, but does not change quality of life. (A)</p> Signup and view all the answers

What was observed in rodents subjected to social defeat?

<p>It caused an immune response and increased macrophages in the BNST. (D)</p> Signup and view all the answers

Which statement about the role of the amygdala and hippocampus is accurate?

<p>The hippocampus inhibits the hypothalamus while the amygdala activates the hypothalamus. (C)</p> Signup and view all the answers

What is a likely effect of psychological stressors on physical well-being?

<p>They can create a perceived threat leading to physiological responses. (C)</p> Signup and view all the answers

Flashcards

Which brain regions are involved in CRF production?

The hypothalamus, amygdala, and insula are brain regions involved in the production of corticotropin-releasing factor (CRF), a key hormone in the stress response.

What are the main determinants of happiness?

The setpoint theory suggests that our happiness levels are partly determined by our genetic predisposition and temperament. However, our intentional activities and life circumstances can significantly influence our happiness.

What are perseverative cognitions associated with?

Perseverative cognitions are repetitive and intrusive thoughts that can contribute to prolonged stress and anxiety. These thoughts are linked to increased heart rate, blood pressure, cortisol levels, and reduced heart rate variability.

What is the impact of stress on dendrites in the hippocampus?

Stress can negatively impact the hippocampus, a brain region crucial for memory and learning, leading to shorter dendrites in neurons. This suggests that prolonged stress may impair cognitive function.

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How does physical activity impact the hippocampus?

Physical activity has a positive impact on the brain, particularly the hippocampus, which is involved in memory and learning. The study suggests that exercise can help maintain cognitive function as we age.

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What is a ganglia?

Ganglia are clusters of nerve cell bodies located outside of the central nervous system, serving as relay stations for both sensory and motor information.

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What are the primary stress hormones?

The main stress hormones according to Lavello are cortisol, epinephrine (adrenaline), and norepinephrine (noradrenaline). These hormones are released during the stress response.

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What is the effect of stress on the small intestine?

Stress can increase the permeability of the small intestine, making it more susceptible to harmful substances. This can trigger an inflammatory response involving mast cells, which release histamine and other inflammatory mediators.

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Asthma and Social Stress

After a social stress task, individuals with asthma demonstrate increased levels of exhaled nitric oxide (FeNO) and cortisol, which are associated with heightened inflammation and stress response. Additionally, there is increased activity in the medial prefrontal cortex (mPFC), a brain region involved in stress regulation.

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Brain Activity and Dyspnea in Asthma

The perception of dyspnea (shortness of breath) in asthma does not show a consistent brain activity pattern. Some areas of the brain show heightened activity compared to healthy controls, while others exhibit reduced activity.

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Cortisol and Catecholamine Synthesis

Stress hormones, like cortisol, play a role in regulating the nervous system and immune responses. Cortisol can enhance the synthesis of catecholamines, such as adrenaline and noradrenaline, in both adrenal medulla and neurons.

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Sedentary Behavior and Inflammation

Sedentary behavior has been linked to increased inflammation markers in the body. These inflammatory changes cannot be reversed solely by engaging in physical activity. This suggests that physical activity alone is not sufficient to counteract the negative effects of a sedentary lifestyle.

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Stress and Asthma Symptoms

Stress directly impacts asthma symptoms through various pathways. Increased levels of inflammatory cells, the release of cortisol, and changes in muscle cells all contribute to exacerbating asthma symptoms during stressful events.

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Social Defeat and Immune Responses

Social defeat, a form of chronic stress in rodents, triggers immune responses in the brain. This is reflected by an increased concentration of macrophages, a type of immune cell, in the bed nucleus of the stria terminalis (BNST) and the amygdala.

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Shared Neural Pathways for Physical and Social Pain

The perception of physical pain and social pain shares common neural pathways. Specifically, activity in the anterior cingulate cortex (ACC) and insula, brain regions involved in pain processing, is highly correlated with empathy, suggesting that the brain processes social pain similar to physical pain.

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Parasympathetic Nervous System Functions

The parasympathetic nervous system, part of the autonomic nervous system, is responsible for maintaining and restoring the body's energy reserves. It carries out various functions such as constricting pupils, contracting airways (bronchoconstriction), and widening blood vessels (vasodilation), all contributing to relaxation and energy conservation.

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Gut-Brain Axis

The gut microbiome communicates with the brain through neuronal and hormonal pathways, influencing stress responses, appetite, and mood.

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Social Influence on Pain Perception

The presence of another person can change how we perceive and process physical sensations. Observing someone in pain can make us more sensitive to our own discomfort.

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Positive Affect & HIV Survival

Higher levels of positive emotions are associated with better survival rates in individuals living with HIV.

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Loneliness & Pulmonary Rehabilitation

Social isolation can negatively impact overall health and well-being. Breaking the cycle of loneliness can improve exercise capacity and quality of life.

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Reduced Sensory Gating

Reduced sensory gating refers to a diminished ability to filter out irrelevant sensory information, leading to a heightened response to stimuli. This can be seen as an over-sensitivity to the external world.

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Study Notes

Reconstructie Health Psychology 2 - January 2024

  • CRF-producing areas include hypothalamus, amygdala, insula, cingular cortex and/or adrenal medulla
  • Setpoint (50%), intentional activity (40%), and circumstances (10%) determine happiness
  • Higher heart rate, higher cortisol, higher blood pressure and lower HRV are associated with perseverative cognitions
  • Dendrites in rodents are shorter in hippocampus, prefrontal cortex (PFC), amygdala, or all of these areas
  • Physical activity impacts the brain, specifically the left hippocampus in rodents. This effect is not seen in humans
  • Ganglia act as a relay station for afferent and efferent nerves
  • Primary stress hormones include cortisol, B-endorphin, and epinephrine according to Lavello
  • Stress affects small intestines by potentially increasing permeability, impacting mast cells, or macrophages. The exact direction is not definitive
  • Blood pH regulation involves CO2 levels. Reduced CO2 leads to increased pH, higher ventilation and increased ventilatory muscles, while increased CO2 leads to lower pH.
  • Acute stress is potentially mediated by a change in ventilation, via a parasympathetic route.
  • Nocebo studies involve the ACC, PAG, PFC, or, ACC, PAG, insula or hippocampus.
  • Cytokine transport involves vagus nerves to reach the brain, with mechanisms involving cytokine transport
  • Cytokines can directly pass the blood-brain barrier (BBB) within 30 minutes (e.g., TNF-α)
  • Mechanisms include a saturable influx transporter (SIT), retrograde axonal transport, and simple diffusion through areas with incomplete BBBs such as circumventricular organs
  • Cytokines can damage the BBB, and increase permeability without directly entering the brain
  • The gut-brain axis involves bidirectional interactions of humoral and neural components.
  • Social stress increases FeNO and cortisol in asthmatics.
  • Brain activity related to perceived breathlessness can differ in asthmatic people vs. non-asthmatic controls.
  • Cortisol's effect on target systems may include influencing catecholamine synthesis in adrenal medulla and neurons
  • Sedentary behavior correlates with increased inflammation markers.
  • Stress directly relates to asthma symptoms by influencing inflammatory cells and muscle cells.
  • Active activity may reduce anxiety and depression and have no impact on quality of life (QoL) metrics
  • Social defeat can lead to immune changes, involving more or fewer macrophages in the BNST or amygdala.
  • Social and physical pain show high correlation with activity in the ACC and insula.
  • The perceived threat of a psychosocial stressor can be determined by possible physical threat or harm.
  • The parasympathetic nervous system influences pupillary constriction, bronchoconstriction, and vasodilation (widening blood vessels).
  • Physical activity may relate to improved interleukin production, interferon, and NK-cell production
  • Cytokine responses have a possible, not definitive, component in the immune response.
  • Amygdala and hippocampus interact regarding hypothalamic activity.
  • Aminergic nuclei output to the frontal-limbic and hypothalamic systems in the brain.
  • COVID-19, particularly involving IL-6 and TNF-α, may include neural damage in lungs and brain

Reduced Sensory Gating

  • Reduced neural filtering and subsequent increased afferent output are possible effects.
  • Acetylcholine may be a hormone in sweat glands.
  • Symptoms related to anxiety in COPD patients include more dyspnea and reduced gray matter in the anterior cingulate cortex (ACC). Exertional activity correlates to gray matter reductions in the ACC.

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