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Guillain-Barré Syndrome (GBS)

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Questions and Answers

What is the function of myelin in the nervous system?

Conducting nerve signals directly

Causing inflammation and destruction

Producing antibodies to fight infection

Providing insulation and speeding the conduction of impulses (correct)

Which nerve is responsible for demyelination in the bulbar muscle weakness?

Glossopharyngeal nerve (correct)

Vagus nerve

Phrenic nerve

Trigeminal nerve

What is the primary concern in the management of GBS?

Preventing cognitive dysfunction

Treating viral infections

Managing autonomic dysfunction

Supporting pulmonary function (correct)

What is the purpose of therapeutic plasma exchange and IVIG in treating GBS?

Decreasing circulating antibody levels Signup and view all the answers

What is the significance of changes in vital capacity and negative inspiratory force in GBS?

Identifying impending neuromuscular respiratory failure Signup and view all the answers

What is the characteristic presentation of GBS?

Symmetric weakness, diminished reflexes, and upward progression of motor weakness Signup and view all the answers

What is the result of the autoimmune attack on the peripheral nerve myelin in Guillain-Barré Syndrome?

Acute, rapid segmental demyelination of peripheral nerves Signup and view all the answers

What percentage of Guillain-Barré Syndrome cases are associated with an antecedent event?

60-70% Signup and view all the answers

Which of the following infectious agents is most commonly associated with the development of Guillain-Barré Syndrome?

Campylobacter jejuni Signup and view all the answers

What is the most accepted theory of the cause of Guillain-Barré Syndrome?

Molecular mimicry Signup and view all the answers

What is the exact location of the immune attack within the peripheral nervous system?

Ganglioside GM1b Signup and view all the answers

What are the symptoms of Guillain-Barré Syndrome?

Ascending weakness, paresthesias, and dyskinesia Signup and view all the answers