Podcast
Questions and Answers
What is the main difference between cephamycins and other cephalosporins?
What is the main difference between cephamycins and other cephalosporins?
- Cephamycins are classified by generation (1–4).
- Cephamycins contain a 7-alpha-methoxy group, imparting resistance to extended-spectrum beta-lactamases. (correct)
- Cephamycins are more effective against gram-negative bacteria.
- Cephamycins have a broader spectrum of activity.
How are cephalosporins classified?
How are cephalosporins classified?
- By their generation (1–4). (correct)
- By their pharmacokinetic characteristics.
- By their resistance to beta-lactam destruction.
- By their source (natural vs semisynthetic) and spectra.
Which of the following bacteria are cephalosporins in the first-generation usually quite active against?
Which of the following bacteria are cephalosporins in the first-generation usually quite active against?
- Gram-positive bacteria (correct)
- Enterococcus spp
- Anaerobic bacteria
- Gram-negative bacteria
Why are cephalosporins generally less susceptible to beta-lactamase destruction than penicillins?
Why are cephalosporins generally less susceptible to beta-lactamase destruction than penicillins?
Which of the following best describes the potential nephrotoxicity of cephalosporins?
Which of the following best describes the potential nephrotoxicity of cephalosporins?
In terms of in vitro incompatibilities, what is an exception when mixing cephalosporins with other drugs?
In terms of in vitro incompatibilities, what is an exception when mixing cephalosporins with other drugs?
What potential interactions of cephalosporins are similar to those of the penicillin group?
What potential interactions of cephalosporins are similar to those of the penicillin group?
Which laboratory determinations may be altered by the cephalosporins?
Which laboratory determinations may be altered by the cephalosporins?
In the US, under what circumstances is extralabel drug use (ELDU) of cephalosporins prohibited?
In the US, under what circumstances is extralabel drug use (ELDU) of cephalosporins prohibited?
What should veterinarians do regarding withdrawal times for cephalosporin products used in animals?
What should veterinarians do regarding withdrawal times for cephalosporin products used in animals?
Which type of elimination is appreciable for the newer cephalosporins?
Which type of elimination is appreciable for the newer cephalosporins?
What may lead to drug accumulation for newer cephalosporins?
What may lead to drug accumulation for newer cephalosporins?
Which cephalosporins have exceptions in maintaining effective blood concentrations for 6–8 hours?
Which cephalosporins have exceptions in maintaining effective blood concentrations for 6–8 hours?
For which type of infections are first-generation cephalosporins particularly useful?
For which type of infections are first-generation cephalosporins particularly useful?
What is ceftiofur approved for in production animals?
What is ceftiofur approved for in production animals?
For what type of infections is ceftiofur not recommended for use in dogs?
For what type of infections is ceftiofur not recommended for use in dogs?
What infections are cephalosporins particularly useful for treating?
What infections are cephalosporins particularly useful for treating?
What may arise with the use of cephalosporins?
What may arise with the use of cephalosporins?
What has been reported due to antimicrobial-induced perturbations in GI flora?
What has been reported due to antimicrobial-induced perturbations in GI flora?
Which of the following bacterial species is NOT effectively targeted by second-generation cephalosporins?
Which of the following bacterial species is NOT effectively targeted by second-generation cephalosporins?
What is the main difference between third-generation and fourth-generation cephalosporins?
What is the main difference between third-generation and fourth-generation cephalosporins?
Which of the following is a characteristic of cephamycins in comparison to other second-generation cephalosporins?
Which of the following is a characteristic of cephamycins in comparison to other second-generation cephalosporins?
Why are third- and fourth-generation cephalosporins designed to be increasingly resistant to beta-lactamases?
Why are third- and fourth-generation cephalosporins designed to be increasingly resistant to beta-lactamases?
What is the primary target of plasmid-mediated beta-lactamases produced by gram-positive bacteria such as Staphylococcus aureus?
What is the primary target of plasmid-mediated beta-lactamases produced by gram-positive bacteria such as Staphylococcus aureus?
What distinguishes ceftiofur, a third-generation cephalosporin, from other cephalosporins?
What distinguishes ceftiofur, a third-generation cephalosporin, from other cephalosporins?
What bacterial strain is specifically mentioned as a target for ceftiofur, a third-generation cephalosporin?
What bacterial strain is specifically mentioned as a target for ceftiofur, a third-generation cephalosporin?
True or False: Second-generation cephalosporins are generally more resistant to beta-lactamases compared with first-generation drugs.
True or False: Second-generation cephalosporins are generally more resistant to beta-lactamases compared with first-generation drugs.
True or False: Third- and fourth-generation cephalosporins have a spectrum that includes Pseudomonas and other problematic coliforms.
True or False: Third- and fourth-generation cephalosporins have a spectrum that includes Pseudomonas and other problematic coliforms.
What role does the 7-aminocephalosporanic acid nucleus play in the structure of cephalosporins?
What role does the 7-aminocephalosporanic acid nucleus play in the structure of cephalosporins?
Why are extended-spectrum beta-lactamases considered a challenge for third- and fourth-generation cephalosporins?
Why are extended-spectrum beta-lactamases considered a challenge for third- and fourth-generation cephalosporins?
What is the mechanism of action of extended-spectrum beta-lactamases (ESBLs)?
What is the mechanism of action of extended-spectrum beta-lactamases (ESBLs)?
What is a notable feature of the standard cephalosporins in terms of their penetration into the central nervous system?
What is a notable feature of the standard cephalosporins in terms of their penetration into the central nervous system?
How are ESBLs detected on susceptibility testing?
How are ESBLs detected on susceptibility testing?
What is a common route of administration for most cephalosporins in animals?
What is a common route of administration for most cephalosporins in animals?
What is a notable feature of cefovecin in terms of its elimination half-life in cats?
What is a notable feature of cefovecin in terms of its elimination half-life in cats?
What does it mean that third- or fourth-generation cephalosporins are often able to penetrate the blood-brain barrier?
What does it mean that third- or fourth-generation cephalosporins are often able to penetrate the blood-brain barrier?
What can be inferred about the pharmacokinetics of cephalosporins from the given text?
What can be inferred about the pharmacokinetics of cephalosporins from the given text?
What is a unique feature of ceftiofur compared to other cephalosporins?
What is a unique feature of ceftiofur compared to other cephalosporins?
