Gram Negative Bacteria Overview
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Questions and Answers

What is the most common symptom of gonococcal infection in males?

  • Greenish-yellow cervical discharge
  • Chronic pelvic pain
  • Painful urination without discharge
  • Yellow, purulent urethral discharge (correct)

What complication can result from untreated gonococcal salpingitis in women?

  • Ectopic pregnancy
  • Cervical cancer
  • Tubal scarring and infertility (correct)
  • Ovarian cysts

What antibiotic is commonly used to treat ophthalmia neonatorum?

  • Erythromycin (correct)
  • Amoxicillin
  • Penicillin
  • Tetracycline

What is the typical consequence of untreated acute conjunctivitis in newborns caused by gonococcus?

<p>Blindness (D)</p> Signup and view all the answers

Which of the following populations is most at risk for meningococcal meningitis outbreaks?

<p>People in close contact environments like schools and military barracks (B)</p> Signup and view all the answers

What is a serious consequence of meningococcal infection aside from meningitis?

<p>Fulminant meningococcemia causing shock (A)</p> Signup and view all the answers

Which symptom is most commonly associated with gonococcal infection in females?

<p>Greenish-yellow cervical discharge (B)</p> Signup and view all the answers

What environmental factor increases the risk of meningococcal outbreaks?

<p>Close contact between individuals (C)</p> Signup and view all the answers

Which genus is associated with nonmotile coccobacilli and is significant in hospital-acquired infections?

<p>Acinetobacter (D)</p> Signup and view all the answers

Which of the following genera primarily causes gastrointestinal diseases?

<p>Shigella (B)</p> Signup and view all the answers

What type of bacteria are found in the gastrointestinal tract and can grow well in the presence of oxygen?

<p>True facultative anaerobes (B)</p> Signup and view all the answers

Which organism is best known for its fimbriae or pili that aid in adherence to host mucosal surfaces?

<p>Escherichia coli (B)</p> Signup and view all the answers

What is a common transmission method for organisms that cause gastrointestinal diseases?

<p>Fecal contamination (D)</p> Signup and view all the answers

Which of the following statements correctly applies to Escherichia coli?

<p>It is part of normal microbiota and can be pathogenic. (B)</p> Signup and view all the answers

What is the primary virulence factor of Neisseria meningitidis?

<p>Polysaccharide capsule (D)</p> Signup and view all the answers

Which of the following genera contains organisms that are primarily extraintestinal pathogens?

<p>Klebsiella (B)</p> Signup and view all the answers

Which component is commonly found in enteric gram-negative rods and is related to endotoxin?

<p>Lipopolysaccharide (LPS) (A)</p> Signup and view all the answers

Which age group is particularly affected by acute fulminating meningococcal septicemia?

<p>Very young children (D)</p> Signup and view all the answers

Which symptom is NOT typically associated with meningococcal meningitis?

<p>Diarrhea (B)</p> Signup and view all the answers

What type of vaccine is MCV4?

<p>Tetravalent vaccine (B)</p> Signup and view all the answers

Where does N. meningitidis initially colonize in the human body?

<p>Nasal cavity (D)</p> Signup and view all the answers

What is the most common causative agent of meningitis among healthy young individuals?

<p>Neisseria meningitidis (C)</p> Signup and view all the answers

Which of the following vaccines protects against serogroup B meningococcal bacteria?

<p>Trumenba® (B)</p> Signup and view all the answers

What is the typical progression of symptoms in meningococcal infections?

<p>Initial fever and malaise evolving to severe headache and rigid neck (B)</p> Signup and view all the answers

What is the primary route of transmission for intestinal diseases caused by E.coli?

<p>Fecal/oral route (B)</p> Signup and view all the answers

Which type of E.coli is most commonly associated with traveler's diarrhea?

<p>Enterotoxigenic E.coli (ETEC) (B)</p> Signup and view all the answers

Which E.coli serotype is commonly known for producing verotoxin?

<p>O157:H7 (D)</p> Signup and view all the answers

What condition can occur due to the infection of enterohemorrhagic E.coli (EHEC)?

<p>Hemolytic uremic syndrome (HUS) (A)</p> Signup and view all the answers

Which type of E.coli is significant for causing diarrhea in infants in poor sanitation areas?

<p>Enteropathogenic E.coli (EPEC) (C)</p> Signup and view all the answers

What is the most common extraintestinal infection caused by E.coli?

<p>Urinary tract infection (UTI) (A)</p> Signup and view all the answers

Enteroinvasive E.coli (EIEC) is associated with which of the following symptoms?

<p>Dysentery-like syndrome (B)</p> Signup and view all the answers

The strain O104:H4 of E.coli is particularly dangerous for which reason?

<p>It combines features of both EAEC and EHEC. (A)</p> Signup and view all the answers

What is a common symptom of Salmonella infection?

<p>Abdominal cramping (B)</p> Signup and view all the answers

Which serotype primarily causes enteric (typhoid) fever?

<p>Salmonella typhi (B)</p> Signup and view all the answers

What is a characteristic clinical feature of shigellosis?

<p>Diarrhea with blood and mucus (C)</p> Signup and view all the answers

Which statement about Campylobacter is true?

<p>C. jejuni typically causes an acute enteritis. (A)</p> Signup and view all the answers

What is the mortality rate associated with enteric (typhoid) fever?

<p>15% (A)</p> Signup and view all the answers

Which pathogen is responsible for causing shigellosis?

<p>Shigella species (D)</p> Signup and view all the answers

What type of infection is predominantly associated with E. coli in neonates?

<p>Neonatal meningitis (D)</p> Signup and view all the answers

What is the shape of Vibrio bacteria?

<p>Short and curved (B)</p> Signup and view all the answers

What is the primary cause of death in untreated cholera?

<p>Severe dehydration (B)</p> Signup and view all the answers

Which species of Yersinia is known as the etiologic agent of bubonic plague?

<p>Y.pestis (C)</p> Signup and view all the answers

What type of disease does Yersinia pestis primarily cause?

<p>Plague (C)</p> Signup and view all the answers

What characteristic motility do Helicobacter species display?

<p>Corkscrew motility (C)</p> Signup and view all the answers

What condition is primarily caused by Haemophilus influenzae?

<p>Bacterial meningitis (B)</p> Signup and view all the answers

What has significantly reduced infections caused by H.influenzae type b?

<p>Vaccine administration (A)</p> Signup and view all the answers

What is the common presentation of plague in its most frequent form?

<p>Bubonic plague (C)</p> Signup and view all the answers

What is the primary clinical significance of Bordetella species?

<p>Causing whooping cough (D)</p> Signup and view all the answers

Flashcards

Gonococcal Genitourinary Infections (Males)

Males experience acute, easily diagnosed infections with yellow, purulent urethral discharge and painful urination.

Gonococcal Genitourinary Infections (Females)

Females are infected in the endocervix, spreading to the urethra and vagina, often with a greenish-yellow cervical discharge and possible intermenstrual bleeding.

Gonococcal Complications (Females)

Can lead to salpingitis, pelvic inflammatory disease, fibrosis, and potentially infertility due to scarring of fallopian tubes.

Ophthalmia Neonatorum

Newborn infection of the conjunctiva (eye lining) acquired during birth from infected mothers.

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Ophthalmia Neonatorum Treatment

Erythromycin is used to treat ophthalmia neonatorum, as it also eliminates Chlamydia trachomatis.

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Neisseria meningitidis Meningitis

A common cause of meningitis, often with a rapid onset and intense symptoms.

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Neisseria meningitidis Fulminant Meningococcemia

Severe form of infection with Neisseria meningitidis, characterized by intravascular coagulation, shock, and potentially fatal circulatory collapse without meningitis.

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Meningitis Outbreaks

Meningitis outbreaks are common in winter and spring, often in close contact settings like schools and military barracks.

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Neonatal Meningitis

A serious infection affecting newborns within the first month of life, often caused by E. coli.

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Nosocomial Infections

Infections acquired during a hospital stay.

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Salmonella Infection

Bacterial infection that can cause both intestinal and extraintestinal diseases, characterized by nausea, vomiting, and diarrhea.

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Typhoidal Salmonella

A severe, life-threatening form of salmonellosis, characterized by fever and abdominal symptoms.

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Campylobacter Infection

Bacterial infection causing inflammation in the intestine, often leading to diarrhea and abdominal pain.

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Shigellosis (Bacillary Dysentery)

Human intestinal disease caused by Shigella species, characterized by bloody diarrhea and severe abdominal cramps.

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Vibrio

A genus of bacteria with short, curved, rod-shaped organisms.

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Shiga Toxin

A toxin produced by Shigella bacteria, causing severe damage to the intestines and leading to dysentery symptoms.

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Meningococcemia

Meningococci entering the bloodstream and rapidly multiplying.

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Meningococcal Meningitis

Infection of the meninges (the lining of the brain and spinal cord) caused by meningococci.

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Meningococcal Septicemia

Life-threatening blood poisoning caused by meningococci, often occurring quickly.

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Meningococcal Polysaccharide Capsule

A protective coating around the meningococcus bacteria, preventing body defenses from attacking them.

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Meningococcal Vaccines

Vaccines that prevent meningococcal disease caused by Neisseria meningitidis bacteria.

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Nasopharynx Colonization

The initial stage of meningococcal infection where the bacteria reside in the back of the throat.

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Virulence Factor

A characteristic or property that makes a microorganism more likely to cause disease.

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Antiphagocytic

Preventing the body's cells from destroying the bacteria

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Moraxella and Infections

Moraxella bacteria can cause respiratory, ear, eye, central nervous system (CNS), and joint infections.

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Acinetobacter and Nosocomial Infections

Acinetobacter are non-moving bacteria that often cause infections in hospitals.

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Gram-negative Rods in GI Tract

Many gram-negative bacteria live in the human digestive system and can cause diseases there or elsewhere in the body.

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Enteric Gram-Negative Rods

Gram-negative bacteria that live in the intestines; some cause diseases in the gut, others elsewhere, or both.

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Escherichia (E. coli)

A type of bacteria found in the gut, that can cause disease both inside and outside the digestive system.

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Opportunistic Pathogen

Bacteria that can cause disease when the body's defenses are weak.

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Salmonella and Shigella

Bacteria that mainly cause gastrointestinal diseases, often through fecal contamination.

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Fecal Contamination

The presence of feces contaminating a surface or substance, facilitating the transmission of bacteria from the gut.

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ETEC

Enterotoxigenic E. coli. A common cause of traveler's diarrhea, often transmitted through contaminated food and water.

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EPEC

Enteropathogenic E. coli. A significant cause of infant diarrhea, especially in areas with poor sanitation.

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EHEC

Enterohemorrhagic E. coli. Causes severe bloody diarrhea (hemorrhagic colitis) and can lead to life-threatening kidney failure (HUS).

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E. coli Strain O157:H7

A common strain of E. coli that produces verotoxin, a potent toxin responsible for the severe symptoms of EHEC infections.

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E. coli Strain O104:H4

A particularly dangerous strain of E. coli that combines the traits of EAEC and EHEC, causing severe and potentially fatal infections.

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EIEC

Enteroinvasive E. coli. Causes dysentery, characterized by fever and bloody stools.

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EAEC

Enteroaggregative E. coli. Can cause traveler's diarrhea and persistent diarrhea in young children.

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E. coli and UTIs

E. coli is the most common cause of urinary tract infections (UTIs), which affect the bladder and kidneys. Women are particularly susceptible.

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What is the most common presentation of plague?

The bubonic/septicemic form is the most frequent clinical presentation of plague.

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What type of bacteria is Helicobacter?

Helicobacter are curved or spiral-shaped bacteria with rapid, corkscrew motility.

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H. influenzae

Haemophilus influenzae, a bacterium that can cause meningitis, especially in young children.

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What is a distinctive symptom of Bordetella pertussis infection?

Bordetella pertussis causes whooping cough, characterized by distinctive coughing fits.

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What is the clinical significance of cholera?

Cholera causes severe dehydration due to massive fluid and electrolyte loss through profuse, watery diarrhea.

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What is the most clinically important member of the Yersinia genus?

Yersinia pestis is the most clinically important Yersinia species, causing plague.

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What family is the Yersinia genus part of?

The Yersinia genus belongs to the Enterobacteriaceae family.

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What are the medically important Yersinia species?

Yersinia enterocolitica, Y. pseudotuberculosis, and Y. pestis are medically important Yersinia species.

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Study Notes

Gram Negative Bacteria

  • Gram-negative bacteria are a large group of bacteria with distinct characteristics, including their reaction to Gram staining.
  • Gram-negative Cocci: Neisseria are non-motile, gram-negative coccobacilli in pairs, responsible for gonorrhea and meningitis.
  • Gram-negative bacilli: Include various types such as enteric bacteria, Campylobacter, Helicobacter, Vibrio, and more. These exhibit diverse characteristics from straight to curved shape, aerobic to anaerobic behavior, and varied locations within the body.
  • Different types of bacteria may impact different areas such as Gastrointestinal tract, Respiratory tract, Genitourinary tract and more.

Overview

  • The organisms in the presentation are commonly found in humans or other animals, living in the gastrointestinal tract, often thriving in the presence of oxygen.
  • Many contain lipopolysaccharide, a contributing factor to their impact as pathogens.
  • They typically constitute a small portion of the whole gastrointestinal tract microbiota, usually gram positive, rather than gram negative.
  • Many of the gram-negative types discussed are significant sources for infectious diseases that can affect various parts of the human body such as intestinal, respiratory, urinary tract and more.

Specific Species

  • Neisseria: Gram-negative cocci; responsible for gonorrhea and meningitis.
  • Haemophilus: Respiratory organisms associated with meningitis.
  • Bordetella: Respiratory pathogens responsible for whooping cough.
  • Legionella: Respiratory infections, primary intracellular parasites.
  • Pseudomonas: Can cause numerous infections, often opportunistic and hospital-acquired.
  • Brucella: Primarily pathogens for animals, but can be transmitted to humans, causing brucellosis; mostly transmitted through consumption of unpasteurized milk or contact with animals.
  • Francisella: Primarily a pathogen of animals, causing tularemia, a zoonotic disease.
  • Yersinia Pestis: Causes bubonic plague, a severe, life-threatening disease.
  • Campylobacter: Often linked to gastrointestinal infections like enteritis.
  • Shigella: Causes shigellosis (bacillary dysentery).
  • Vibrio: Responsible for cholera, a severe diarrheal disease.
  • Escherichia coli: Can cause various intestinal infections including, diarrhea, urinary infections and more.

Clinical Significance & Treatment

  • Many of the discussed gram-negative species can cause infections that vary in their severity, symptoms, locations impacted and treatment.
  • Appropriate antibiotics are imperative for treatment.
  • Various methods of testing and identification are available to determine the particular causative species in a patient.
  • Understanding transmission routes is key for infection control.

Vaccines

  • Conjugate meningococcal vaccine (MCV4) is used in adolescents and adults.
  • Various vaccines offer protection against related diseases.

Additional Notes

  • Understanding the different classifications of gram-negative bacteria (cocci, bacilli) and their specific characteristics is important for proper diagnosis and treatment.
  • Gram staining is a critical diagnostic tool.
  • Understanding routes of transmission for each bacterial species is essential for infection control efforts.

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Gram Negative Bacteria PDF

Description

Explore the characteristics and classifications of gram-negative bacteria in this quiz. Learn about various types such as Neisseria and their impact on different body systems. Understand their unique structures and roles in human health and disease.

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