Gram-Negative Bacteria Overview
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Questions and Answers

What disease is primarily associated with the genus Brucella?

  • Pneumonia
  • Whooping cough
  • Undulant fever (correct)
  • Tularemia
  • Which organism is known for causing a mild pertussis-like illness?

  • Legionella
  • Bordetella (correct)
  • Pseudomonas aeruginosa
  • Francisella tularensis
  • Which of the following pathogens is primarily responsible for hospital-acquired infections?

  • Brucella
  • Pseudomonas aeruginosa (correct)
  • Francisella tularensis
  • Legionella
  • Which pathogen is primarily a respiratory tract infection agent?

    <p>Legionella</p> Signup and view all the answers

    Which species of Brucella is specifically associated with swine?

    <p>B. suis</p> Signup and view all the answers

    What is a common symptom of gonococcal infection in males?

    <p>Yellow, purulent urethral discharge</p> Signup and view all the answers

    What complication can occur in women due to gonococcal salpingitis?

    <p>Tubal scarring leading to infertility</p> Signup and view all the answers

    What is the primary treatment for ophthalmia neonatorum?

    <p>Erythromycin</p> Signup and view all the answers

    What bacterium is frequently associated with severe epidemics of meningitis in developing nations?

    <p>N. meningitidis</p> Signup and view all the answers

    Which symptom is characteristic of meningococcemia caused by N. meningitidis?

    <p>Intravascular coagulation</p> Signup and view all the answers

    In which situations are outbreaks of meningitis caused by N. meningitidis most commonly favored?

    <p>Close contact situations like schools and barracks</p> Signup and view all the answers

    What is the most common type of discharge seen in females with gonococcal infection?

    <p>Greenish-yellow cervical discharge</p> Signup and view all the answers

    What can untreated acute conjunctivitis in newborns lead to?

    <p>Blindness</p> Signup and view all the answers

    Which species of Neisseria is known to cause meningitis?

    <p>Neisseria meningitidis</p> Signup and view all the answers

    What type of bacteria is Neisseria gonorrhoeae classified as?

    <p>Gram-negative diplococcus</p> Signup and view all the answers

    Which is a common mode of transmission for Neisseria gonorrhoeae?

    <p>Sexual contact</p> Signup and view all the answers

    Which of the following is NOT a characteristic of Neisseria species?

    <p>Facultative anaerobic</p> Signup and view all the answers

    From which type of cells is Neisseria gonorrhoeae often observed in clinical samples?

    <p>Polymorphonuclear leukocytes</p> Signup and view all the answers

    Which gram-negative organism is known for causing infections primarily in humans?

    <p>Pseudomonas</p> Signup and view all the answers

    What characteristic feature differentiates gonococci from meningococci under the microscope?

    <p>They cannot be distinguished</p> Signup and view all the answers

    What is the primary significance of Neisseria meningitidis in public health?

    <p>It is a frequent cause of meningitis.</p> Signup and view all the answers

    What is a major cause of neonatal meningitis occurring within the first month of life?

    <p>E.coli</p> Signup and view all the answers

    Which of the following symptoms is NOT typically associated with salmonella gastroenteritis?

    <p>Skin rash</p> Signup and view all the answers

    Which type of fever is primarily caused by serotype typhi?

    <p>Typhoid fever</p> Signup and view all the answers

    What is the mortality rate approximately associated with enteric (typhoid) fever?

    <p>15%</p> Signup and view all the answers

    Which bacterium is known for causing shigellosis or bacillary dysentery?

    <p>Shigella</p> Signup and view all the answers

    Which of the following is a characteristic symptom of shigellosis?

    <p>Diarrhea with blood and mucus</p> Signup and view all the answers

    Which genus is characterized by curved, spiral, or S-shaped organisms?

    <p>Campylobacter</p> Signup and view all the answers

    What type of infections can members of the genus Vibrio cause?

    <p>Intestinal and extraintestinal infections</p> Signup and view all the answers

    Which of the following organisms are primarily responsible for gastrointestinal diseases?

    <p>Salmonella</p> Signup and view all the answers

    What feature is common among enteric gram-negative rods found in the GI tract?

    <p>They contain lipopolysaccharide (LPS).</p> Signup and view all the answers

    Which of the following organisms can be classified as an opportunistic pathogen?

    <p>E. coli</p> Signup and view all the answers

    Which characteristic is important for E. coli adherence to host mucosal surfaces?

    <p>Fimbriae or pili</p> Signup and view all the answers

    What is a common mode of transmission for GI diseases caused by certain pathogens?

    <p>Fecal contamination</p> Signup and view all the answers

    Which genus is primarily gastrointestinal and does not typically cause extraintestinal diseases?

    <p>Vibrio</p> Signup and view all the answers

    What type of bacteria are members of the genus Acinetobacter?

    <p>Nonmotile coccobacilli</p> Signup and view all the answers

    Which of the following diseases is NOT typically caused by organisms primarily found in the GI tract?

    <p>Respiratory infections</p> Signup and view all the answers

    What is the primary virulence factor of N. meningitidis?

    <p>Polysaccharide capsule</p> Signup and view all the answers

    Which population is particularly susceptible to N. meningitidis infections?

    <p>Young children</p> Signup and view all the answers

    What severe symptom can develop quickly due to meningococcal infection?

    <p>Severe headache</p> Signup and view all the answers

    How quickly can meningococcal septicemia occur in a healthy individual?

    <p>In less than 12 hours</p> Signup and view all the answers

    What type of vaccine replaced the quadrivalent polysaccharide vaccine for meningitis prevention in U.S. adolescents and adults?

    <p>MCV4 vaccine</p> Signup and view all the answers

    Which of the following meningococcal vaccines is specifically designed for serogroup B?

    <p>Bexsero®</p> Signup and view all the answers

    What is a common presentation in patients with meningococcal infections aside from fever?

    <p>Petechial rash</p> Signup and view all the answers

    What is the typical initial site of colonization for N. meningitidis in humans?

    <p>Nasopharynx</p> Signup and view all the answers

    Study Notes

    Gram-Negative Bacteria

    • Gram-negative bacteria are a diverse group of microorganisms.
    • They are categorized by morphology (cocci or bacilli) and further classified as straight or curved.
    • Straight bacteria include Enteric bacteria, Legionella, Yersinia, Francisella, Pasteurella, Pseudomonas, and Acinetobacter.
    • Curved bacteria include Campylobacter, Helicobacter, and Vibrio.

    Cocci

    • Gram-negative cocci bacteria are often grouped together as diplococci.
    • Neisseria is a genus of Gram-negative diplococci.
    • Infections caused by Neisseria include gonorrhea and meningitis.
    • Neisseria species can be identified as gram-negative diplococci.

    Rods (bacilli)

    • Gram-negative bacilli are a category of bacteria.
    • Gram-negative rods are commonly separated into aerobic and anaerobic groups.

    Overview

    • The genus Neisseria consists of gram-negative, aerobic cocci.
    • Two Neisseria species are pathogenic for humans: N. gonorrhoeae and N. meningitidis.
    • Gonococci and meningococci are nonmotile diplococci.

    Gonorrhea

    • Gonorrhea is a sexually transmitted infection (STI) and a common disease.
    • The causal agent is Neisseria gonorrhoeae.
    • The infection typically involves the urethra and vagina.
    • Infections in both genders manifest differently.

    Meningitis

    • Meningitis caused by N. meningitidis is a serious condition.
    • The symptoms appear quickly and include severe headaches.
    • The organism spreads from the throat into the bloodstream.

    Clinical Significance

    • N. meningitidis initially colonizes the nasopharynx causing pharyngitis.
    • It can lead to meningitis and/or fulminating septicemia.
    • N. meningitidis currently remains a major cause of meningitis.

    Other E. coli infections

    • Enteroinvasive E. coli (EIEC) exhibit a dysentery-like syndrome.
    • Enteroadherent E. coli (EAEC) cause traveler's diarrhea or persistent diarrhea in young children.

    UTI-causing organisms

    • E. coli is the leading cause of UTIs.
    • Other Gram-negative bacteria are also involved in UTIs.

    Neonatal meningitis/Nosocomial infections

    • E. coli is one of the major causes of neonatal meningitis.
    • Nosocomial infections are infections originating in hospitals or other healthcare settings.

    Helicobacter pylori

    • They are curved or spiral-shaped rods.
    • Helicobacter pylori cause gastritis and stomach ulcers.
    • They are also known to potentially cause stomach cancer.

    Respiratory Organisms

    • Haemophilus can cause meningitis.
    • Bordetella causes whooping cough.
    • Legionella causes pneumonia.

    Gram-Negative Rods Associated with Respiratory Tract

    • Haemophilus influenzae causes meningitis, otitis media, sinusitis, pneumonia and epiglottitis.
    • Bordetella pertussis causes whooping cough.
    • Legionella pneumophila causes pneumonia

    Anaerobic Gram-negative Rods

    • Bacteroides are among the bacteria frequently found in the human gut and involved in peritonitis.

    Diseases caused by Gram-Negative Rods

    • Escherichia-related infections.
    • Salmonella causes gastroenteritis and typhoid fever.
    • Campylobacter infections (e.g. enteritis).
    • Shigella leads to shigellosis or bacillary dysentery.
    • Vibrio is associated with cholera.
    • Yersinia-related diseases.
    • Pseudomonas can cause infections.

    Zoonotic Organisms

    • Pathogens from animals are often transmitted to humans through contact, contaminated food or water.
    • Brucella is a common zoonotic disease.
    • Other zoonotic diseases like tularemia and pasteurellosis are caused by pathogens spread by animals.

    Vaccines

    • Meningococcal conjugate vaccines are available and used in adolescents and adults.
    • Vaccination schedules are in place for preventative measures.

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    Description

    This quiz focuses on the classification and characteristics of gram-negative bacteria, including their morphological types such as cocci and bacilli. Key genera like Neisseria and their associated infections are highlighted. Test your knowledge of these microorganisms and their significance in human health.

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