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Graded Response Assay Interpolation Quiz

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Graded Response Assay Interpolation Quiz

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Questions and Answers

What is the advantage of using the interpolation method in graded response assays?

Less time-consuming and reliable compared to other bioassay methods

Involves no statistical data and many calculations (correct)

Requires multiple concentrations in the curve

Highly dependent on the dose range

How is the sensitivity of tissue first determined in bioassays?

By plotting a dose-response curve with a known agonist (correct)

By extending the dose range to include more data points

By diluting the sample after the reaction is read

By calculating the unknown concentrations directly

What should be done if the drug response does not fall within the dose range in bioassays?

Calculate the unknown concentrations using linear regression

Use statistical data for analysis

Dilute the sample after the reaction is read

Extend the dose range by including more concentrations (correct)

What is a key requirement to calculate unknown concentrations using the linear regression method in bioassays?

Having a high and low standard response (C) Signup and view all the answers

Why is it important not to dilute the sample after the reaction is read in bioassays?

To avoid affecting the sensitivity of the tissue (B) Signup and view all the answers

What role does extending the dose range play in interpreting dose response plots?

It helps in calculating unknown concentrations accurately (B) Signup and view all the answers

In bioassays, what is the focus of a direct assay?

Dose (D) Signup and view all the answers

What is the main limitation of a direct assay?

Lack of dosaging options for a dose-ranging study (D) Signup and view all the answers

In an indirect assay, what is the focus of the analysis?

Dose-response relationship (D) Signup and view all the answers

How is the relative potency of a test sample determined in an indirect assay?

Through statistical analysis of the dose-response relation (A) Signup and view all the answers

What does the equation 𝑐𝑜𝑛𝑐𝑒𝑛𝑡𝑟𝑎𝑡𝑖𝑜𝑛𝑜𝑓 𝑢𝑛𝑘𝑛𝑜𝑤𝑛 = 𝑑𝑜𝑠𝑒𝑟𝑒𝑠𝑡 × 𝑐𝑜𝑛𝑐𝑒𝑛𝑡𝑟𝑎𝑡𝑖𝑜𝑛 𝑠𝑡𝑎𝑛𝑑𝑎𝑟𝑑 represent in bioassays?

Calculation of unknown concentrations (A) Signup and view all the answers

What aspect of bioassays is highlighted by the statement 'every dose there’s a response'?

Dose-response relationship (B) Signup and view all the answers