Gout and Uric Acid Metabolism
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Gout and Uric Acid Metabolism

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Questions and Answers

What is the primary feature of amyloidosis?

  • Autoimmune reaction
  • Vascular occlusion
  • Abnormal protein fibrils deposition (correct)
  • Chronic inflammatory response

    • Which of the following is a common cause of amyloidosis?

  • Asthma
  • Obesity
  • Long-term hemodialysis (correct)
  • Chronic hypertension

    • What is the characteristic of amyloid deposits on T2-weighted images?

  • Low signal intensity (correct)
  • High signal intensity
  • Intermediate signal intensity
  • Variable signal intensity

    • What is the typical presentation of amyloidosis in the spine?

    <p>Discitis or neuropathic disorder</p> Signup and view all the answers

    Which of the following is a frequent presentation of amyloidosis?

    <p>Shoulder pain and carpal tunnel syndrome</p> Signup and view all the answers

    What is the characteristic of amyloid deposits on T1-weighted images?

    <p>Intermediate to low signal intensity</p> Signup and view all the answers

    What is the enhancement pattern of amyloid deposits?

    <p>Peripheral enhancement</p> Signup and view all the answers

    What is the joint manifestation of amyloidosis?

    <p>Joint space widening</p> Signup and view all the answers

    What is the classification of amyloidosis based on?

    <p>Type of amyloid protein produced</p> Signup and view all the answers

    What is the characteristic of amyloid deposits on contrast-enhanced fat-suppressed T1-weighted images?

    <p>Marginal enhancement</p> Signup and view all the answers

    What is the characteristic of soft tissue swelling in acute gout attacks?

    <p>Asymmetric swelling at the joint</p> Signup and view all the answers

    What is the characteristic of chronic tophaceous gout on radiographs?

    <p>Calcification of tophi can occur in severe renal disease</p> Signup and view all the answers

    What is the characteristic of 'rat bite' erosions on radiographs?

    <p>Overhanging edge is made up of newly formed bone</p> Signup and view all the answers

    What is the characteristic of tendon infiltration in gout?

    <p>Tendon thickening and predisposition to tendon tear</p> Signup and view all the answers

    What is the characteristic of tophi on US?

    <p>Hyperechoic and poorly defined</p> Signup and view all the answers

    What is the characteristic of tophi on CT?

    <p>Attenuation is highly variable</p> Signup and view all the answers

    What is the typical duration of flares in CPPD?

    <p>Days or weeks</p> Signup and view all the answers

    Which of the following joints is most commonly affected in CPPD?

    <p>Knee</p> Signup and view all the answers

    What is the gold standard for evaluating CPPD?

    <p>Evaluation of synovial fluid for CPP</p> Signup and view all the answers

    What is the characteristic of CPP crystals in CPPD?

    <p>Short and weakly positive birefringent</p> Signup and view all the answers

    What is the characteristic of gouty tophus on radiographs?

    <p>May show amorphous calcification</p> Signup and view all the answers

    What is the characteristic of gouty tophus on MRI?

    <p>Low signal intensity on T1-weighted and variably high or low signal on T2-weighted</p> Signup and view all the answers

    What is the common feature of OA with CPPD?

    <p>Less involvement of the IP joints</p> Signup and view all the answers

    What is the characteristic of erosions in gout?

    <p>Sharply marginated and may be intraarticular or paraarticular</p> Signup and view all the answers

    What is the typical presentation of HADD?

    <p>Calcific tendinitis, calcific bursitis, and calcific periarthritis</p> Signup and view all the answers

    What is the diagnosis made by in gout?

    <p>Inspection of the synovial fluid</p> Signup and view all the answers

    What is the term for cartilage calcification due to CPP crystal deposition?

    <p>Chondrocalcinosis</p> Signup and view all the answers

    What is the characteristic of acute CPP crystal arthritis?

    <p>Rapid onset of joint inflammation</p> Signup and view all the answers

    What is the primary route of elimination of uric acid?

    <p>Renal excretion</p> Signup and view all the answers

    What is a common underlying factor contributing to gout?

    <p>Chronic renal disease</p> Signup and view all the answers

    What is a dietary factor that may contribute to gout?

    <p>A diet high in purines</p> Signup and view all the answers

    What is the typical demographic affected by gout?

    <p>Middle-aged or elderly males</p> Signup and view all the answers

    What is the effect of excessive alcohol consumption on uric acid?

    <p>Results in both uric acid overproduction and underexcretion</p> Signup and view all the answers

    What is the result of high urate concentrations in the body?

    <p>Formation of uric acid crystals</p> Signup and view all the answers

    What is the most common musculoskeletal manifestation of amyloidosis?

    <p>Subchondral lucent lesions</p> Signup and view all the answers

    Which of the following is a common site of involvement in amyloidosis?

    <p>Wrist</p> Signup and view all the answers

    What is the typical MRI appearance of amyloid deposits?

    <p>Low to intermediate signal intensity on all pulse sequences</p> Signup and view all the answers

    What is a potential complication of tendon involvement in amyloidosis?

    <p>Tendon tear</p> Signup and view all the answers

    In which of the following conditions is amyloidosis often seen?

    <p>Chronic renal failure</p> Signup and view all the answers

    What is the typical appearance of vertebral involvement in amyloidosis?

    <p>Disc narrowing with endplate sclerosis</p> Signup and view all the answers

    What is the purpose of Congo red stain in biopsy?

    <p>To identify amyloid deposits</p> Signup and view all the answers

    What is the characteristic of soft tissue involvement in amyloidosis?

    <p>Masslike deposits of amyloid</p> Signup and view all the answers

    In which of the following conditions is musculoskeletal involvement rare?

    <p>Familial Mediterranean fever</p> Signup and view all the answers

    What is the characteristic of spine involvement in amyloidosis?

    <p>Destructive changes at the disc</p> Signup and view all the answers

    What is the primary method of treatment for HADD?

    <p>NSAIDs and aspiration/irrigation of the calcified material</p> Signup and view all the answers

    What is the characteristic appearance of HA on MRI?

    <p>Low signal on all pulse sequences</p> Signup and view all the answers

    Why is CT sometimes necessary in the diagnosis of HADD?

    <p>To show the typical amorphous calcification better than radiographs</p> Signup and view all the answers

    What is the characteristic appearance of HADD on ultrasound?

    <p>An amorphous focus of increased echogenicity with variable degrees of acoustic shadowing</p> Signup and view all the answers

    What is a common effect of β2 microglobulin accumulation in patients on long-term hemodialysis?

    <p>Formation of amyloid fibrils</p> Signup and view all the answers

    What is a possible joint manifestation of amyloidosis?

    <p>Erosive changes in joints or vertebral endplates</p> Signup and view all the answers

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