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Questions and Answers
Uric acid deposition in the joints leads to the formation of what structures characteristic of gout?
Uric acid deposition in the joints leads to the formation of what structures characteristic of gout?
In which part of the body does increased excretion of uric acid potentially cause crystal deposition?
In which part of the body does increased excretion of uric acid potentially cause crystal deposition?
What is the approximate percentage of primary gout cases that can be classified as idiopathic?
What is the approximate percentage of primary gout cases that can be classified as idiopathic?
Which enzyme abnormality is mentioned as a potential cause of primary gout?
Which enzyme abnormality is mentioned as a potential cause of primary gout?
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Increased nucleic acid turnover rate is a cause of increased uric acid production. In which condition is this turnover rate commonly seen?
Increased nucleic acid turnover rate is a cause of increased uric acid production. In which condition is this turnover rate commonly seen?
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What is a major cause of reduced uric acid excretion leading to secondary gout?
What is a major cause of reduced uric acid excretion leading to secondary gout?
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What level of proteinuria (protein in urine) is classified as Glomerular proteinuria?
What level of proteinuria (protein in urine) is classified as Glomerular proteinuria?
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Why is microalbuminuria significant in patients with diabetes mellitus and hypertension?
Why is microalbuminuria significant in patients with diabetes mellitus and hypertension?
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Which hormone primarily influences water balance in the kidneys?
Which hormone primarily influences water balance in the kidneys?
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What is the primary nitrogen-containing product of protein catabolism?
What is the primary nitrogen-containing product of protein catabolism?
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What is defined as abnormally high BUN in the blood?
What is defined as abnormally high BUN in the blood?
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Which of the following is NOT a laboratory test commonly used to assess kidney function?
Which of the following is NOT a laboratory test commonly used to assess kidney function?
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Which test is primarily used to assess the glomerular filtration rate (GFR)?
Which test is primarily used to assess the glomerular filtration rate (GFR)?
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What substance makes up more than 75% of the total non-protein nitrogen (NPN) in the body?
What substance makes up more than 75% of the total non-protein nitrogen (NPN) in the body?
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What does the BUN/Creatinine ratio help distinguish among?
What does the BUN/Creatinine ratio help distinguish among?
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What characterizes intrinsic renal failure?
What characterizes intrinsic renal failure?
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What condition is indicated by abnormally high urea nitrogen levels in the blood?
What condition is indicated by abnormally high urea nitrogen levels in the blood?
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Which substance is used as a standard measure to estimate GFR?
Which substance is used as a standard measure to estimate GFR?
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Which hormone promotes tubular reabsorption of calcium in the kidneys?
Which hormone promotes tubular reabsorption of calcium in the kidneys?
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What enzymatic cycle is responsible for the biosynthesis of urea?
What enzymatic cycle is responsible for the biosynthesis of urea?
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What is microalbuminuria indicative of?
What is microalbuminuria indicative of?
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Which of the following substances does not contribute significantly to the formation of urea?
Which of the following substances does not contribute significantly to the formation of urea?
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What is a common consequence of hyperuricemia?
What is a common consequence of hyperuricemia?
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What is the nephrotic-range proteinuria threshold?
What is the nephrotic-range proteinuria threshold?
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What is an early indicator of onset of nephropathy?
What is an early indicator of onset of nephropathy?
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What type of proteinuria is characterized by the overflow of small molecular weight proteins into urine?
What type of proteinuria is characterized by the overflow of small molecular weight proteins into urine?
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Which condition is associated with hemoglobinuria?
Which condition is associated with hemoglobinuria?
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What is the primary biochemical finding associated with pre-renal failure?
What is the primary biochemical finding associated with pre-renal failure?
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What condition often results from the accumulation of urate crystals in synovial fluid?
What condition often results from the accumulation of urate crystals in synovial fluid?
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Which cause is classified as prerenal uremia?
Which cause is classified as prerenal uremia?
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What laboratory assessment is primarily used to measure the end product of protein catabolism?
What laboratory assessment is primarily used to measure the end product of protein catabolism?
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Which biochemical condition is caused by high levels of endogenous H+ excretion inability in acute renal failure?
Which biochemical condition is caused by high levels of endogenous H+ excretion inability in acute renal failure?
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Which type of proteinuria indicates damage to the renal tubules?
Which type of proteinuria indicates damage to the renal tubules?
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How is the majority of urate excreted from the body?
How is the majority of urate excreted from the body?
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Which of the following is a cause of post-renal failure?
Which of the following is a cause of post-renal failure?
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What condition causes an increase in both urea and creatinine levels?
What condition causes an increase in both urea and creatinine levels?
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Which type of proteinuria can occur due to physical exertion or fever?
Which type of proteinuria can occur due to physical exertion or fever?
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What primarily dictates the formation of uric acid in the body?
What primarily dictates the formation of uric acid in the body?
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What is a common result of hyperuricemia?
What is a common result of hyperuricemia?
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What substance is commonly used to measure glomerular filtration rate (GFR)?
What substance is commonly used to measure glomerular filtration rate (GFR)?
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What type of renal failure results from prolonged renal circulatory insufficiency?
What type of renal failure results from prolonged renal circulatory insufficiency?
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How does acute renal failure (ARF) primarily manifest in clinical settings?
How does acute renal failure (ARF) primarily manifest in clinical settings?
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Which method is NOT used to calculate creatinine clearance?
Which method is NOT used to calculate creatinine clearance?
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In the diagnosis of renal insufficiency, what is the primary goal of measuring GFR?
In the diagnosis of renal insufficiency, what is the primary goal of measuring GFR?
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What factor is NOT known to affect serum creatinine levels?
What factor is NOT known to affect serum creatinine levels?
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What is a common cause of pre-renal acute renal failure?
What is a common cause of pre-renal acute renal failure?
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How is creatinine clearance expressed mathematically?
How is creatinine clearance expressed mathematically?
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What physiological change occurs in response to decreased blood supply to the kidneys?
What physiological change occurs in response to decreased blood supply to the kidneys?
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Flashcards
Blood Urea Nitrogen (BUN)
Blood Urea Nitrogen (BUN)
A laboratory test that measures urea nitrogen in the blood, assessing kidney function.
Glomerular Filtration Rate (GFR)
Glomerular Filtration Rate (GFR)
The volume of filtrate formed per unit time by all nephrons in both kidneys.
Uremia
Uremia
A condition characterized by abnormally high levels of urea in the blood.
Azotemia
Azotemia
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Prerenal azotemia
Prerenal azotemia
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Gout
Gout
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Microalbuminuria
Microalbuminuria
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Proteinuria
Proteinuria
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Kidney Functions
Kidney Functions
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Arginine Vasopressin (AVP)
Arginine Vasopressin (AVP)
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Aldosterone
Aldosterone
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Parathyroid Hormone
Parathyroid Hormone
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Renin
Renin
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Serum Creatinine
Serum Creatinine
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Creatinine Clearance
Creatinine Clearance
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GFR (Glomerular Filtration Rate)
GFR (Glomerular Filtration Rate)
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Inulin
Inulin
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Acute Renal Failure (ARF)
Acute Renal Failure (ARF)
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Pre-renal ARF
Pre-renal ARF
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ADH (Antidiuretic Hormone)
ADH (Antidiuretic Hormone)
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Biochemical findings in pre-renal failure
Biochemical findings in pre-renal failure
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Post-renal failure causes
Post-renal failure causes
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Hyperuricaemia
Hyperuricaemia
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Uric Acid formation
Uric Acid formation
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Urate excretion pathways
Urate excretion pathways
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Metabolic acidosis in ARF
Metabolic acidosis in ARF
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Overflow Proteinuria
Overflow Proteinuria
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Hemoglobinuria
Hemoglobinuria
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Myoglobinuria
Myoglobinuria
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Tubular Proteinuria
Tubular Proteinuria
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Alpha-1 Microglobulin
Alpha-1 Microglobulin
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Transient Proteinuria
Transient Proteinuria
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Orthostatic Proteinuria
Orthostatic Proteinuria
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High BUN Causes
High BUN Causes
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Uric Acid
Uric Acid
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Primary Gout
Primary Gout
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Secondary Gout
Secondary Gout
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Glomerular Proteinuria
Glomerular Proteinuria
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Protein/Creatinine Ratio
Protein/Creatinine Ratio
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Study Notes
Kidney Function Tests
- Kidney function tests assess kidney function using blood urea nitrogen (BUN), serum creatinine, and glomerular filtration rate (GFR).
- Uremia is abnormally high blood urea nitrogen.
- Azotemia is an elevated plasma concentration of urea and creatinine in renal insufficiency.
- Prerenal, renal (intrinsic), and postrenal causes of elevated BUN/creatinine differentiate pathophysiologic processes.
- Calculating creatinine clearance estimates glomerular filtration rate (GFR).
- Factors affecting plasma creatinine levels include muscle mass, certain drugs, age, and sex.
- GFR is the volume of filtrate made per unit time by nephrons in both kidneys.
- Substances used to measure GFR are inulin, creatinine, and cystatin C.
Acute Renal Failure (ARF)
- ARF is an abrupt decline in renal function, manifesting as low GFR and increased BUN/creatinine levels.
- Classification includes pre-renal, renal, and post-renal causes.
- Pre-renal ARF is caused by reduced blood supply to the kidneys (e.g., hemorrhage, dehydration).
- Renal ARF is due to intrinsic kidney damage (e.g., glomerulonephritis, toxins, myoglobinuria).
- Postrenal ARF is caused by obstruction in urine outflow (e.g., stones, prostate issues).
Urea
- Urea is the main nitrogenous waste product of protein catabolism.
- Urea is produced in the liver and primarily excreted via kidneys.
Creatinine
- Creatinine is a breakdown product of phosphocreatine in muscle tissue.
- Measured in serum to assess renal function.
- Serum creatinine levels are slightly higher in males due to muscle mass.
Glomerular Filtration Rate (GFR)
- GFR is the volume of filtrate formed by all nephrons per unit of time.
- Measuring GFR helps detect and diagnose renal insufficiency.
- GFR is used to adjust drug dosages in patients with kidney problems.
- Inulin, cystatin C, and creatinine are used to measure GFR.
Causes of High BUN (Uremia)
- Prerenal uremia: reduced blood flow to the kidney
- Renal uremia: intrinsic kidney disease (acute/chronic glomerulonephritis, polycystic kidney disease)
- Postrenal uremia: obstruction in urine outflow (stones, prostate enlargement, malignancy)
Proteinuria
- Proteinuria is the presence of abnormal amounts of protein in urine.
- Types of proteinuria include glomerular, overflow, and tubular.
- Glomerular proteinuria results from damage to the glomeruli.
- Overflow proteinuria may be caused by elevated low-molecular-weight proteins in the blood (e.g., hemoglobin, myoglobin).
- Tubular proteinuria is from decreased reabsorption capacity of proteins in the tubules
Uric Acid and Gout
- Uric acid is produced from purine metabolism.
- A high level, hyperuricemia, can cause gout.
- Gout causes inflammation in joints.
- Primary Gout is often familial.
- Secondary Gout can be due to increased production or decreased excretion of uric acid.
Clinical Significance of Serum Creatinine
- Creatinine is freely filtered by glomeruli, with minimal tubular secretion.
- Elevated serum creatinine suggests decreased renal excretion, often a sign of renal dysfunction.
- Serum creatinine levels are somewhat higher in males and affected by age, sex, muscle mass, certain drugs, exercise, and high protein diets/ catabolic states.
Creatinine Clearance
- Creatinine clearance is the volume of plasma cleared of creatinine by the kidneys per minute.
- Calculating creatinine clearance helps assess kidney function.
Microalbuminuria
- Microalbuminuria is a small amount of albumin in urine.
- It's an early sign of kidney disease, especially in patients with diabetes and hypertension.
Case Scenario
- The case scenario presents a patient with possible acute kidney injury (AKI) due to decreased renal function.
- Reduced renal function (low GFR) and abnormal blood chemistry data may indicate heart failure.
Summary of Kidney Lecture
- The lecture covers laboratory assessments of renal function, focusing on key kidney health/disease indicators (BUN, creatinine, etc).
- Specific tests for renal function include blood urea and blood urea nitrogen (BUN), Uremia, Azotemia , and Creatinine, GFR.
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Description
Test your knowledge on the pathophysiology of gout and related kidney disorders. This quiz covers topics such as uric acid metabolism, proteinuria, and the significance of certain enzymes. Perfect for students in medical or health-related fields looking to understand these conditions better.