16 Questions
What is the main function of Neisseria Spp's LOS?
Contains endotoxin
Which proteins in Neisseria Spp are involved in nutrient/waste exchange and inhibition of phagolysosome fusion in PMNs?
Porin Proteins
How does Neisseria Meningitidis primarily enter the body?
Via the Trojan Horse mechanism through phagocytes
Which age group is Neisseria Meningitidis endemic in?
Teens and young adults
What is the most common complication of Neisseria Meningitidis infection?
Meningitis
What symptom distinguishes Fulminant meningococcal septicemia caused by Neisseria Meningitidis?
Intraocular hemorrhage
Which age group is Neisseria Gonorrhea mainly transmitted among?
People aged 15-24 years old
Who are the most common asymptomatic carriers/reservoirs of Neisseria Gonorrhea?
Women
Which Streptococcus Pyogenes virulence factor blocks complement by binding fibrinogen?
M-protein
What is the primary function of Streptococcus Pyogenes exotoxin SLO?
Cytolysis of leukocytes
Which Streptococcus Pyogenes virulence factor degrades hyaluronic acid to aid in tissue invasion?
Hyaluronidase
What is the role of Lipoteichoic acid in Streptococcus Pyogenes infections?
Promoting tissue adhesion
Which Streptococcus Pyogenes exotoxin is crucial for diagnosis based on ASO titer measurement?
SPE A
What is the main function of Streptococcus Pyogenes invasin DNAse during infection?
Degradation of extracellular DNA barriers
Which adhesin in Streptococcus Pyogenes is involved in binding to host cell receptors?
FbP
What is the primary function of Streptococcus Pyogenes exotoxin SLS?
Causing leukocyte cytolysis through β-hemolysis
Study Notes
- Adherence in gonorrhea is facilitated by pili, Opa proteins on microvilli and non-ciliated cells, and Por.Major, leading to purulent discharge in infected sites like the urethra, cervix, epididymis, prostate, and anus within 2-5 days.
- Symptoms of gonorrhea include pyuria, dysuria, pharyngitis from oral sex, and anorectal gonorrhea can cause proctitis.
- Complications of gonorrhea can include prostatitis, orchitis, pelvic inflammatory diseases like endometriosis, salpingitis, tubo-ovarian abscess, pelvic peritonitis, spontaneous abortion, and early rupture of fetal membranes.
- Neonatal infections of gonorrhea can result in Ophthalmia Neonatorum with acute conjunctivitis confirmed by lab diagnosis.
- Moraxella, a normal flora of the upper respiratory tract, can lead to otitis media, sinusitis, and pneumonia in adults, including those with COPD.
- Neisseria and Moraxella are aerobic, fastidious Gram-negative diplococci, with Neisseria being DNase-, Cat+ and true pathogens, while Moraxella is DNase+, Cat+ and opportunistic pathogens.
- Treatment for N.gonorrhea includes ceftriaxone + doxycycline, while prophylaxis for neonatal infections involves antibiotics or 1% silver nitrate solution. Neisseria meningitidis is treated with penicillin or cephalosporins, and breastfeeding provides passive immunity.
Test your knowledge on the signs, symptoms, and complications of gonorrhea. Explore how adherence by pili, Opa, and Por.Major contribute to the infection, along with major symptoms such as purulent discharge, pyuria, and dysuria. Learn about various modes of transmission and possible complications like prostatitis, orchitis, and pelvic inflammatory disease.
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