5 Questions
Which enzyme catalyzes the ATP-dependent phosphorylation of glucose in glycolysis?
Hexokinase
What is the product of the isomerization of glucose-6-phosphate in glycolysis?
Fructose-6-phosphate
Which enzyme catalyzes the cleavage of fructose-1,6-bisphosphate into two triose phosphates?
Aldolase
Which molecule undergoes isomerization in glycolysis, converting into glyceraldehyde-3-phosphate?
Dihydroxyacetone phosphate
Which molecule acts as a hexose derivative phosphorylated at both carbons 1 and 6 in glycolysis?
Fructose-1,6-bisphosphate
Study Notes
Glycolysis Reactions
- Glycolysis begins with the ATP-dependent phosphorylation of glucose, catalyzed by hexokinase, forming Glucose 6-phosphate.
- Glucose-6-phosphate is converted into its isomer, fructose-6-phosphate through isomerization.
- The second ATP-dependent phosphorylation is catalyzed by phosphofructokinase, forming a hexose derivative, fructose-1,6-bisphosphate (FBP), phosphorylated at both carbons 1 and 6.
- Fructose-1,6-bisphosphate is cleaved to give 2 three-carbon intermediates, glyceraldehyde-3-phosphate and dihydroxyacetone phosphate (DHAP), catalyzed by aldolase.
- Dihydroxyacetone phosphate (DHAP) is converted into glyceraldehyde-3-phosphate (GAP) through isomerization catalyzed by triose phosphate isomerase.
Test your knowledge of the key reactions in glycolysis, including ATP-dependent phosphorylation of glucose, isomerization of glucose-6-phosphate, and the cleavage into two three-carbon molecules. Identify the enzymes involved and the products formed in each step.
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