Biochemistry: PFK-1 Reaction Regulation
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Questions and Answers

What inhibits hexokinase isozymes I, II, and III?

  • Acetyl-CoA
  • Fructose 2,6-bisphosphate
  • Long-chain fatty acids
  • G6P (correct)

Which enzyme forms G6P in the liver for glycogen synthesis?

  • Hexokinase II
  • Pyruvate kinase
  • Glucokinase (correct)
  • Phosphofructokinase-1

Which allosteric regulator inhibits Phosphofructokinase-1?

  • Long chain fatty acids
  • AMP
  • Citrate (correct)
  • Fructose 2,6-bisphosphate

What triggers Pyruvate Kinase activation?

<p>Accumulation of F1,6BP (D)</p> Signup and view all the answers

How is Pyruvate Kinase allosterically inhibited?

<p>Long-chain fatty acids (A)</p> Signup and view all the answers

Which enzyme is controlled by covalent modification and allosteric regulation?

<p>$ ext{Pyruvate Kinase}$ (C)</p> Signup and view all the answers

$ ext{Enolase}$ inhibitors are part of the inhibitors of glycolysis. What specifically do these inhibitors target?

<p>$ ext{Enolase itself}$ (C)</p> Signup and view all the answers

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