Glycolysis and Glucose Transport Quiz
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Questions and Answers

What is the key regulatory step in glycolysis?

  • Isomerization of G6P to F6P
  • Cleavage of F1,6BP to GAP and DHAP
  • Transport of glucose into the cell
  • Phosphorylation of glucose to G6P (correct)
  • Which enzyme catalyzes the cleavage of F1,6BP to GAP and DHAP?

  • Aldolase (correct)
  • Hexokinase
  • Phosphoglucose isomerase
  • Triose phosphate isomerase
  • Which protein is responsible for the transport of glucose into cells?

  • Glyceraldehyde-3-phosphate dehydrogenase
  • GLUT4 (correct)
  • PFK-1
  • Phosphoglucose isomerase
  • Which enzyme catalyzes the phosphorylation of fructose-6-phosphate to F1,6BP?

    <p>Phosphofructokinase-1</p> Signup and view all the answers

    Which molecule is responsible for the allosteric stimulation of PFK-1?

    <p>AMP</p> Signup and view all the answers

    Which enzyme phosphorylates glucose in glycolysis?

    <p>Hexokinase</p> Signup and view all the answers

    Which enzyme is a key regulatory enzyme in glycolysis?

    <p>PFK-1</p> Signup and view all the answers

    What is the net gain of ATP per glucose molecule in glycolysis?

    <p>2 ATPs</p> Signup and view all the answers

    What is the shift in pyruvate metabolism under anaerobic conditions?

    <p>Pyruvate is converted to lactate</p> Signup and view all the answers

    What is the Warburg effect?

    <p>A shift to glycolysis in cancer cells</p> Signup and view all the answers

    What is the byproduct of glycolysis in RBCs that promotes oxygen release in tissues?

    <p>2,3-BPG</p> Signup and view all the answers

    What is the branch point for glucose-6-phosphate in the cell?

    <p>Glycolysis</p> Signup and view all the answers

    Study Notes

    Key Facts About Glycolysis and Its Regulation

    • Glycolysis is a ten-step process, regulated by specific enzymes for precise control.
    • Hexokinase phosphorylates glucose, and PFK-1 is a key regulatory enzyme in glycolysis.
    • Glyceraldehyde-3-phosphate dehydrogenase generates NADH, which can be used in oxidative phosphorylation.
    • Anaerobic conditions shift pyruvate metabolism to lactate production.
    • Glycolysis generates a net gain of 2 ATPs per glucose via substrate-level phosphorylation.
    • The Warburg effect is observed in many cancers, favoring glycolysis over oxidative phosphorylation even under normoxic conditions.
    • RBCs rely on glycolysis for ATP as they lack mitochondria and form 2 NADH per glucose.
    • Pyruvate kinase deficiency leads to hemolytic anemia, and galactosemia results from a deficiency in galactose-1-phosphate uridyltransferase.
    • PFK-1 deficiency leads to Tarui disease, and arsenic inhibits lipoic acid, causing lactic acidosis.
    • 2,3-BPG is a byproduct of glycolysis in RBCs, promoting oxygen release in tissues.
    • Glucose-6-phosphate is a branch point, entering glycolysis, the pentose phosphate pathway, or glycogen storage.
    • Alcohol metabolism produces excess NADH, inhibiting gluconeogenesis, and thiamine deficiency impairs pyruvate dehydrogenase, causing lactic acidosis.

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    Description

    Test your knowledge on Glycolysis and Glucose Transport with this quiz! Learn about the 10-step process of metabolizing glucose, the production of ATP and NADH, and the family of transport proteins called GLUT proteins. See how much you know about insulin-responsive GLUT4 and its presence in adipose tissue. Take the quiz now and become a master of Glycolysis and Glucose Transport!

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