Podcast Beta
Questions and Answers
What is the key regulatory step in glycolysis?
Which enzyme catalyzes the cleavage of F1,6BP to GAP and DHAP?
Which protein is responsible for the transport of glucose into cells?
Which enzyme catalyzes the phosphorylation of fructose-6-phosphate to F1,6BP?
Signup and view all the answers
Which molecule is responsible for the allosteric stimulation of PFK-1?
Signup and view all the answers
Which enzyme phosphorylates glucose in glycolysis?
Signup and view all the answers
Which enzyme is a key regulatory enzyme in glycolysis?
Signup and view all the answers
What is the net gain of ATP per glucose molecule in glycolysis?
Signup and view all the answers
What is the shift in pyruvate metabolism under anaerobic conditions?
Signup and view all the answers
What is the Warburg effect?
Signup and view all the answers
What is the byproduct of glycolysis in RBCs that promotes oxygen release in tissues?
Signup and view all the answers
What is the branch point for glucose-6-phosphate in the cell?
Signup and view all the answers
Study Notes
Key Facts About Glycolysis and Its Regulation
- Glycolysis is a ten-step process, regulated by specific enzymes for precise control.
- Hexokinase phosphorylates glucose, and PFK-1 is a key regulatory enzyme in glycolysis.
- Glyceraldehyde-3-phosphate dehydrogenase generates NADH, which can be used in oxidative phosphorylation.
- Anaerobic conditions shift pyruvate metabolism to lactate production.
- Glycolysis generates a net gain of 2 ATPs per glucose via substrate-level phosphorylation.
- The Warburg effect is observed in many cancers, favoring glycolysis over oxidative phosphorylation even under normoxic conditions.
- RBCs rely on glycolysis for ATP as they lack mitochondria and form 2 NADH per glucose.
- Pyruvate kinase deficiency leads to hemolytic anemia, and galactosemia results from a deficiency in galactose-1-phosphate uridyltransferase.
- PFK-1 deficiency leads to Tarui disease, and arsenic inhibits lipoic acid, causing lactic acidosis.
- 2,3-BPG is a byproduct of glycolysis in RBCs, promoting oxygen release in tissues.
- Glucose-6-phosphate is a branch point, entering glycolysis, the pentose phosphate pathway, or glycogen storage.
- Alcohol metabolism produces excess NADH, inhibiting gluconeogenesis, and thiamine deficiency impairs pyruvate dehydrogenase, causing lactic acidosis.
Studying That Suits You
Use AI to generate personalized quizzes and flashcards to suit your learning preferences.
Description
Test your knowledge on Glycolysis and Glucose Transport with this quiz! Learn about the 10-step process of metabolizing glucose, the production of ATP and NADH, and the family of transport proteins called GLUT proteins. See how much you know about insulin-responsive GLUT4 and its presence in adipose tissue. Take the quiz now and become a master of Glycolysis and Glucose Transport!
