5 Questions
Which enzymes regulate the Glycolysis pathway?
Hexokinase, Phosphofructokinase & Pyruvate Kinase
What are the two types of control mechanisms mentioned in the text for metabolic pathways?
Local control and Global control
Which tissues are mentioned as sites where local control of metabolism occurs?
Muscle and RBCs
What is the major role of liver cells in metabolism?
Maintaining blood levels of various nutrients
Which type of control involves hormone-activated signal cascades?
Global control
Study Notes
Regulation of Glycolysis Pathway
- The Glycolysis pathway is regulated by control of three enzymes: Hexokinase, Phosphofructokinase, and Pyruvate Kinase.
Local Control of Metabolism
- Local control of metabolism involves regulatory effects of varied concentrations of pathway substrates or intermediates, benefiting the cell itself.
- This type of control occurs in extrahepatic tissues, such as muscle and red blood cells (RBCs).
Global Control of Metabolism
- Global control of metabolism benefits the whole organism and often involves hormone-activated signal cascades.
- The liver has a major role in global control, particularly in maintaining blood levels of various nutrients, including glucose.
- Hepatocytes (liver cells) have key roles in metabolism, with a focus on maintaining whole-body homeostasis.
Learn about the regulation of the Glycolysis pathway by control of three key enzymes: Hexokinase, Phosphofructokinase, and Pyruvate Kinase. Explore the concepts of local and global control of metabolism, and the roles of liver cells in maintaining overall organism health.
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