BIOCHEM-C Glucose Homeostasis & Fuel Metabolism - Dra. Flores - 2023-01

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Questions and Answers

What are the three sources of glucose for the body?

  • Glycogenolysis, gluconeogenesis, ketone bodies
  • Glycogenolysis, glycolysis, lipolysis
  • Glycogenolysis, lipogenesis, ketogenesis
  • Intestinal absorption of food, glycolysis, gluconeogenesis (correct)

What can glucose be stored as once transported into cells?

  • Glycogen (correct)
  • Ketone bodies
  • Triglycerides
  • Fatty acids

What is the ultimate long-term energy-storage material derived from excess glucose?

  • Alanine
  • Triglycerides (correct)
  • Fatty acids
  • Lactate

Which process involves the conversion of excess glucose to fatty acids?

<p>Lipogenesis (B)</p> Signup and view all the answers

Which molecules are the main substrates for gluconeogenesis?

<p>Lactate (B)</p> Signup and view all the answers

What is the primary energy source during prolonged fasting and prolonged exercise?

<p>Fatty acids (B)</p> Signup and view all the answers

Which organ is responsible for the bulk of glucose output during fasting?

<p>Liver (A)</p> Signup and view all the answers

During prolonged fasting, what is stored in the adipose tissue?

<p>Triglycerides (B)</p> Signup and view all the answers

Which statement is true about muscle energy sources?

<p>Muscle uses both glucose and fatty acids as energy sources. (B)</p> Signup and view all the answers

What is the main function of alanine and lactate in muscle?

<p>They contribute to gluconeogenesis by being transported to the liver. (A)</p> Signup and view all the answers

In which tissues does glycogenolysis occur with the release of cellular glucose into the bloodstream?

<p>Muscle and liver (C)</p> Signup and view all the answers

What is the primary fuel used by the brain?

<p>Glucose (A)</p> Signup and view all the answers

Which hormone is centrally important in orchestrating the switch from glycogen synthesis after meals to glycogen breakdown and gluconeogenesis?

<p>Insulin (A)</p> Signup and view all the answers

What is the primary function of insulin during a surge in its concentration?

<p>Inhibits glucose production (C)</p> Signup and view all the answers

Which hormone(s) counteract the effects of insulin and promote glycogenolysis, gluconeogenesis, and lipolysis?

<p>Glucagon, catecholamines, cortisol, and growth hormone (A)</p> Signup and view all the answers

What controls insulin secretion in the β-cell?

<p>Glucose metabolism (B)</p> Signup and view all the answers

What effect does the increase in ATP/ADP ratio have on the cell?

<p>It closes the ATP-sensitive potassium channels, decreasing potassium efflux and depolarizing the cell (B)</p> Signup and view all the answers

What is the function of C-peptide as mentioned in the text?

<p>It serves as a marker of beta cell function (A)</p> Signup and view all the answers

What happens when insulin attaches to its receptor according to the text?

<p>It activates tyrosine kinase activity, causing the enzyme to dephosphorylate (B)</p> Signup and view all the answers

Which substances can also stimulate insulin secretion according to the text?

<p>Amino acids and free fatty acids (A)</p> Signup and view all the answers

What is the role of PDK1 in the IRS-PI3K-Akt signaling pathway?

<p>Phosphorylates the Akt kinase (C)</p> Signup and view all the answers

Which protein is involved in the PI3K-independent pathway that stimulates glucose transport?

<p>TC-10 (B)</p> Signup and view all the answers

What does the activation of some isoforms of protein kinase C (PKC) regulate in the IRS-PI3K-Akt signaling pathway?

<p>Glucose transport (B)</p> Signup and view all the answers

What is a key concept in glucose homeostasis and crucial to understanding the pathogenesis of type 2 diabetes?

<p>Insulin resistance (A)</p> Signup and view all the answers

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