Glutamate Recruitment in Neural Science
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Questions and Answers

In the context of cortical plasticity, what does altered synaptic functioning refer to?

  • Changes in the number of neurons
  • Changes in the speed of action potentials
  • Changes in neurochemical concentrations
  • Changes in the structure and function of synapses (correct)
  • Which process underlies learning, memory, and recovery/reorganization processes?

  • Synaptic modulation (correct)
  • Axon growth inhibition
  • Myelin sheath disintegration
  • Neurotransmitter depletion
  • What is the basis of cortical plasticity?

  • Blood flow alterations
  • Neuronal firing rate changes
  • Brain size increase
  • Altered synaptic functioning (correct)
  • How is cortical plasticity related to learning and memory?

    <p>Through altering synaptic functioning</p> Signup and view all the answers

    What is the role of synaptic modulation in cortical plasticity?

    <p>Facilitating learning and memory processes</p> Signup and view all the answers

    How does altered synaptic functioning contribute to recovery and reorganization processes?

    <p>By allowing for structural changes at synapses</p> Signup and view all the answers

    What is the pivotal finding mentioned in the text regarding cortical plasticity?

    <p>Repetitive stimulation causing long-term potentiation</p> Signup and view all the answers

    What is the key point related to glutamate synapses in the experimental model?

    <p>Functional and structural synaptic changes</p> Signup and view all the answers

    Which phase of long-term potentiation identified by Bliss & Collingridge is protein kinase independent and lasts up to one hour?

    <p>STP causing temporary reorganization</p> Signup and view all the answers

    In the context of cortical plasticity, what effect does high-frequency stimulation have on glutamate synapses?

    <p>Long-term potentiation charges</p> Signup and view all the answers

    What is the role of NMDAR & AMPAR in the short and long term effects mentioned in the text?

    <p>Mediating functional and structural synaptic changes</p> Signup and view all the answers

    What kind of synaptic changes are associated with an experimental model typically involving 100Hz for 1 second on glutamate synapses?

    <p>Functional and structural synaptic changes</p> Signup and view all the answers

    What neurotransmitter is downregulated while glutamate is upregulated?

    <p>GABA</p> Signup and view all the answers

    Which process involves changes in synaptic structure including dendrites and spines growing and contracting?

    <p>LTP and LTD</p> Signup and view all the answers

    What controls the excitability of horizontal connections involved in cortical map modeling?

    <p>GABAergic inhibition</p> Signup and view all the answers

    In the context of adaptations to retinal lesions, what leads to disinhibition in the peri-lesion zone?

    <p>Retraction of inhibitory neurons' axonal arbor</p> Signup and view all the answers

    Which factor promotes dendritic growth and is increased in the context of adaptations to retinal lesions?

    <p>BDNF</p> Signup and view all the answers

    What rapid changes are observed in the context of inhibitory alterations around lesion zones?

    <p>Increase in GABA levels</p> Signup and view all the answers

    What is the term used to describe the alteration in synaptic strength due to changes in release probability or receptor properties?

    <p>Presynaptic effect</p> Signup and view all the answers

    Which process involves the formation or loss of dendritic spines and modification of synapse number?

    <p>Synaptic structure</p> Signup and view all the answers

    What is a characteristic of late LTP (Long-Term Potentiation) as mentioned in the text?

    <p>Increased number of dendritic spines</p> Signup and view all the answers

    Which area serves as a site for research on neuroplasticity according to the text?

    <p>Subventricular zone</p> Signup and view all the answers

    What is involved in cortical plasticity as a result of altered afferent input, training, or pathology according to the text?

    <p>Neuronal rewiring</p> Signup and view all the answers

    Which process in plasticity involves unmasking or disinhibition of pre-existing cortical connections through GABA's role?

    <p>&quot;Unmasking&quot;</p> Signup and view all the answers

    What is the main effect of LTP on AMPAR according to the text?

    <p>Insertion by exocytosis</p> Signup and view all the answers

    Which molecular process leads to the formation of new dendritic spines in the context of cortical plasticity?

    <p>PKCA pathway persistence</p> Signup and view all the answers

    What is the role of calmodulin in the context of LTP?

    <p>Activation of PKCA pathway</p> Signup and view all the answers

    What happens when the same stimulus activates two receptors in LTP?

    <p>Increase in response</p> Signup and view all the answers

    In the context of long-term potentiation, what is the consequence of AMPAR diffusion across the membrane?

    <p>Enhancement of synaptic contacts</p> Signup and view all the answers

    What is the primary mechanism through which LTP induces pre- and post-synaptic effects according to Kandel et al. 2013?

    <p>Activation of PKCA pathway</p> Signup and view all the answers

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