Glutamate Receptors and Excitotoxicity in Alzheimer's Disease

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What is the role of inflammation in the normal function of the brain?

It is necessary for normal brain function (correct)

It causes necrosis

It leads to apoptosis

It prevents excitotoxicity

Which protein aggregates in Lewy bodies in Parkinson's disease?

Phosphorylated tau

Amyloid Beta

Huntingtin

Alpha-synuclein (correct)

What is the process of ubiquitination involved in?

Prevention of excitotoxicity

Activation of proteasome

Targeted degradation of intracellular proteins (correct)

Formation of Lewy bodies

Which type of protein aggregation disrupts other signaling cascades and sequesters proteins?

Alpha-synuclein aggregation Signup and view all the answers

What may be the result of misfolded and/or aggregated proteins in neurodegenerative conditions?

Linkage to appearance of pathological hallmarks and neurotoxicity Signup and view all the answers

Why is drug discovery currently facing challenges in Alzheimer's disease?

The drugs are only targeting ABP and neglecting other pathways Signup and view all the answers

What is the central role of glutamate receptors in excitotoxicity?

Contribute to neuronal death Signup and view all the answers

What is the role of amyloid beta plaques (ABP) and tau neurofibrillary tangles (TNTs) in Alzheimer's disease?

ABP and TNTs contribute to neurocompromise and neuronal loss Signup and view all the answers

What is the significance of trophic factor withdrawal in relation to Alzheimer's disease?

Trophic factor withdrawal is believed to be an important factor in causing Alzheimer's disease Signup and view all the answers

What happens when tau, a protein involved in neuronal communication, becomes phosphorylated?

It leads to neurocompromise by becoming blocked Signup and view all the answers

How is the availability of proteasome related to neurodegenerative diseases?

Decreased proteasome availability leads to the aggregation of proteins Signup and view all the answers

What is the association between BDNF (Brain-Derived Neurotrophic Factor) and Alzheimer's disease?

Loss of BDNF correlates with Alzheimer's disease Signup and view all the answers

What is the potential consequence of trophic factor withdrawal in relation to Alzheimer's disease?

Increased neuronal cell death Signup and view all the answers

How does phosphorylated tau impact neuronal communication?

Inhibits the neurocompromise process Signup and view all the answers

What is the role of necrosis in Alzheimer's disease, as suggested by the text?

It is now considered more important than previously thought Signup and view all the answers

What is the likely impact of decreased availability of proteasome in the context of neurodegenerative diseases?

Accumulation of aggregated proteins Signup and view all the answers

What potentially happens in the mitochondria that could impact neurons and contribute to neurodegenerative conditions?

Mitochondrial dysfunction affecting neurons Signup and view all the answers

What correlates with Alzheimer's disease more strongly than amyloid beta plaques, according to the text?

Phosphorylated tau Signup and view all the answers

What is the process that heavily ubiquitinated proteins undergo in the cell?

Recognition by the proteasome Signup and view all the answers

What is the potential consequence of stimulating the proteasome too much in the context of Alzheimer's disease?

Disruption of normal cellular processes Signup and view all the answers

In neurodegenerative conditions, misfolded and/or aggregated proteins might be linked to which of the following?

Appearance of pathological hallmarks Signup and view all the answers

Glutamate Receptors and Excitotoxicity in Alzheimer's Disease

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