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Questions and Answers
What does the glomerular filtration rate (GFR) measure?
What does the glomerular filtration rate (GFR) measure?
- Plasma ultrafiltration rate
- Body surface area
- Renal excretory function (correct)
- Serum creatinine production
How is the glomerular filtration rate (GFR) usually expressed?
How is the glomerular filtration rate (GFR) usually expressed?
- 150 ± 25mL/min/1.73m2 (correct)
- 200 ± 30mL/min/1.73m2
- 250 ± 50mL/min/1.73m2
- 100 ± 20mL/min/1.73m2
Which compound is most widely used in clinical practice to indirectly assess GFR?
Which compound is most widely used in clinical practice to indirectly assess GFR?
- Serum albumin
- Urea
- Serum creatinine (correct)
- Glucose
What are the most widely used equations to estimate GFR from serum creatinine measurements?
What are the most widely used equations to estimate GFR from serum creatinine measurements?
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What has increased recognition of moderate kidney damage and encouraged early deployment of protective therapies?
What has increased recognition of moderate kidney damage and encouraged early deployment of protective therapies?
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Which component is the GFR proportionate to?
Which component is the GFR proportionate to?
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Study Notes
Glomerular Filtration Rate (GFR)
- GFR measures the flow rate of fluid filtered through the glomeruli of the kidney.
Unit of Measurement
- GFR is usually expressed in milliliters per minute (mL/min).
Clinical Assessment of GFR
- Creatinine is the compound most widely used in clinical practice to indirectly assess GFR.
Estimating GFR from Serum Creatinine
- The most widely used equations to estimate GFR from serum creatinine measurements are the Cockcroft-Gault equation and the Modification of Diet in Renal Disease (MDRD) equation.
Impact on Kidney Disease Management
- Increased recognition of moderate kidney damage has encouraged early deployment of protective therapies.
Physiological Correlation
- GFR is proportionate to the surface area of the glomerular capillaries.
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