6 Questions
What does the glomerular filtration rate (GFR) measure?
Renal excretory function
How is the glomerular filtration rate (GFR) usually expressed?
150 ± 25mL/min/1.73m2
Which compound is most widely used in clinical practice to indirectly assess GFR?
Serum creatinine
What are the most widely used equations to estimate GFR from serum creatinine measurements?
Modification of Diet in Renal Disease (MDRD) and Chronic Kidney Disease Epidemiology Collaboration (CKD-EPI)
What has increased recognition of moderate kidney damage and encouraged early deployment of protective therapies?
Routine reporting of estimated GFR (eGFR) by laboratories
Which component is the GFR proportionate to?
Body size
Study Notes
Glomerular Filtration Rate (GFR)
- GFR measures the flow rate of fluid filtered through the glomeruli of the kidney.
Unit of Measurement
- GFR is usually expressed in milliliters per minute (mL/min).
Clinical Assessment of GFR
- Creatinine is the compound most widely used in clinical practice to indirectly assess GFR.
Estimating GFR from Serum Creatinine
- The most widely used equations to estimate GFR from serum creatinine measurements are the Cockcroft-Gault equation and the Modification of Diet in Renal Disease (MDRD) equation.
Impact on Kidney Disease Management
- Increased recognition of moderate kidney damage has encouraged early deployment of protective therapies.
Physiological Correlation
- GFR is proportionate to the surface area of the glomerular capillaries.
Test your knowledge about the glomerular filtration rate (GFR) and its significance in measuring renal excretory function. This quiz covers the assessment methods and reference values associated with GFR.
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