Glomerular Diseases Overview

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Questions and Answers

What does glomerulonephritis literally mean?

  • Inflammation of renal pelvis
  • Inflammation of interstitium
  • Inflammation of tubules
  • Inflammation of glomeruli (correct)

What is the hallmark of glomerular disease?

  • Glycosuria
  • Pyuria
  • Proteinuria (correct)
  • Hematuria

Which type of antibody deposition is observed in small-vessel vasculitis?

  • IgG deposition
  • No antibody deposition (correct)
  • IgA deposition
  • IgM deposition

What is the classification basis for glomerulonephritis?

<p>Histopathological appearances (C)</p> Signup and view all the answers

Which disease is NOT associated with inflammation of glomeruli?

<p>Alport’s syndrome (B)</p> Signup and view all the answers

Flashcards

Glomerulonephritis

Inflammation of the tiny blood vessels in the kidneys called glomeruli.

Proteinuria

The presence of excessive protein in the urine, indicating damage to the glomeruli.

Small-Vessel Vasculitis

A type of inflammation affecting small blood vessels. It does not involve antibody deposition.

Histopathological Appearances

The basis for classifying glomerulonephritis, relying on microscopic examination of kidney tissue.

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Alport’s Syndrome

A genetic disorder affecting collagen in the kidneys, not related to glomerular inflammation.

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Study Notes

Glomerulonephritis

  • "Glomerulonephritis" literally means inflammation of the glomeruli (glomerulo- meaning "relating to glomeruli" and -nephritis meaning "inflammation of the kidney")

Hallmark of Glomerular Disease

  • The hallmark of glomerular disease is the presence of hematuria (blood in the urine) and/or proteinuria (excess protein in the urine)

Antibody Deposition in Small-Vessel Vasculitis

  • In small-vessel vasculitis, the type of antibody deposition observed is granular or "lumpy-bumpy" pattern of Immunoglobulin G (IgG) and Complement 3 (C3) deposition

Classification of Glomerulonephritis

  • Glomerulonephritis is classified based on the pathogenesis and histological features of the disease

Disease NOT Associated with Glomeruli Inflammation

  • Diabetes mellitus is a disease NOT associated with inflammation of glomeruli

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