GI Drugs: Loperamide Quiz
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GI Drugs: Loperamide Quiz

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Questions and Answers

What is the prototype drug for antidiarrheal treatment?

  • Bismuth subsalicylate
  • Psyllium
  • Loperamide (correct)
  • Diphenoxylate
  • Which mnemonic can help remember Loperamide's effectiveness?

  • Dave eLOPEd in Mexico (correct)
  • Never Forget Loperamide
  • Travelers Need Antidiarrheals
  • Laura Always Stays Inside
  • What is the maximum recommended dose of loperamide in a 24-hour period?

  • 10mg
  • 6mg
  • 4mg
  • 8mg (correct)
  • Which medication class should not be used with loperamide due to drowsiness risk?

    <p>Antihistamines</p> Signup and view all the answers

    Does loperamide cross the blood-brain barrier?

    <p>No, it does not</p> Signup and view all the answers

    Which type of water should patients avoid while taking loperamide?

    <p>Tonic water</p> Signup and view all the answers

    What dangerous effect can result from drinking tonic water while taking loperamide?

    <p>QT prolongation</p> Signup and view all the answers

    Which side effects are associated with loperamide?

    <p>Dizziness, dry mouth, drowsiness</p> Signup and view all the answers

    Is loperamide considered an opioid receptor agonist?

    <p>True, it is a full agonist</p> Signup and view all the answers

    What serious condition can prolonged QT interval lead to?

    <p>Torsades de Pointes</p> Signup and view all the answers

    Study Notes

    Antidiarrheal Drug Overview

    • Prototype Drug: Loperamide is the standard antidiarrheal medication.
    • Mnemonic for Loperamide: "Dave eLOPEd in Mexico and had travelers diarrhea so he took LOPERamide" helps remember its use.

    Loperamide Side Effects

    • Common side effects include dizziness, dry mouth, and drowsiness.

    Drug Interaction Advisories

    • Caution with Antihistamines: Due to increased drowsiness, avoid combining loperamide with antihistamines.
    • Quinine Interaction: Patients should not drink tonic water while taking loperamide, as it contains quinine, which can cause QT prolongation when mixed with loperamide.

    Pharmacokinetics and Mechanism

    • Blood-Brain Barrier: Loperamide does cross the blood-brain barrier but does not cause opioid-like responses in the CNS.
    • Mechanism: It is an opioid receptor agonist, specifically binding to mu-opioid receptors in the gut.

    Dosing Instructions and Safety

    • Dosing Guidance: Initial dose is 2 pills (4mg) after the first loose bowel movement, followed by 2mg after each additional bowel movement.
    • Maximum Dose: The maximum recommended dose of loperamide is 8mg within a 24-hour period.

    Cardiovascular Considerations

    • QT Prolongation: A prolonged QT interval can lead to serious arrhythmias like Torsades de Pointes and potential sudden cardiac death.
    • Medication Interactions: Loperamide should not be taken with CNS depressants due to risks of severe drowsiness, and with medications that cause QT prolongation, including specific antiarrhythmics, macrolides, fluoroquinolones, antipsychotics, antidepressants, and antiemetics.

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    Description

    Test your knowledge on Loperamide, an antidiarrheal medication. This quiz covers its prototype, side effects, dosing guidelines, and interactions with other drugs. Perfect for nursing students or anyone interested in pharmacology.

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