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Questions and Answers
Which medication is noted as a reasonable alternative to insulin for certain women?
Which medication is noted as a reasonable alternative to insulin for certain women?
What was the outcome associated with women randomized to metformin in comparison to insulin?
What was the outcome associated with women randomized to metformin in comparison to insulin?
What is the common dosage range for glyburide?
What is the common dosage range for glyburide?
Which of the following risks has been associated with glyburide use during pregnancy?
Which of the following risks has been associated with glyburide use during pregnancy?
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What was the finding of the initial meta-analysis regarding glyburide compared to insulin?
What was the finding of the initial meta-analysis regarding glyburide compared to insulin?
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What outcome did the recent meta-analysis indicate regarding preterm birth rates for metformin?
What outcome did the recent meta-analysis indicate regarding preterm birth rates for metformin?
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What condition should glyburide not be used in due to a specific allergy?
What condition should glyburide not be used in due to a specific allergy?
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What were the findings regarding macrosomia in previous meta-analyses when comparing glyburide to insulin?
What were the findings regarding macrosomia in previous meta-analyses when comparing glyburide to insulin?
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What is the fasting plasma glucose level threshold according to the Carpenter and Coustan criteria for diagnosing gestational diabetes mellitus?
What is the fasting plasma glucose level threshold according to the Carpenter and Coustan criteria for diagnosing gestational diabetes mellitus?
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Which criterion indicates a 1-hour plasma glucose level for gestational diabetes according to the Carpenter and Coustan guidelines?
Which criterion indicates a 1-hour plasma glucose level for gestational diabetes according to the Carpenter and Coustan guidelines?
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What diagnosis criteria is generally required for gestational diabetes mellitus according to the provided classification?
What diagnosis criteria is generally required for gestational diabetes mellitus according to the provided classification?
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For a plasma glucose level of 2 hours, what is the threshold according to the National Diabetes Data Group?
For a plasma glucose level of 2 hours, what is the threshold according to the National Diabetes Data Group?
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Which of the following conditions applies to the use of diagnostic criteria for gestational diabetes mellitus in practice settings?
Which of the following conditions applies to the use of diagnostic criteria for gestational diabetes mellitus in practice settings?
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According to the proposed diagnostic criteria, what is the 3-hour plasma glucose threshold as per the Carpenter and Coustan criteria?
According to the proposed diagnostic criteria, what is the 3-hour plasma glucose threshold as per the Carpenter and Coustan criteria?
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What is the conversion of a fasting level of 95 mg/dL in mmol/L according to the Carpenter and Coustan criteria?
What is the conversion of a fasting level of 95 mg/dL in mmol/L according to the Carpenter and Coustan criteria?
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What do the established plasma glucose levels aim to achieve?
What do the established plasma glucose levels aim to achieve?
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What is the recommended blood glucose value before meals for managing gestational diabetes mellitus?
What is the recommended blood glucose value before meals for managing gestational diabetes mellitus?
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Which of the following dietary approaches is recommended for managing gestational diabetes?
Which of the following dietary approaches is recommended for managing gestational diabetes?
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How frequently should blood glucose values be reviewed when they are abnormal?
How frequently should blood glucose values be reviewed when they are abnormal?
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What method is commonly suggested to manage carbohydrate intake for women with gestational diabetes?
What method is commonly suggested to manage carbohydrate intake for women with gestational diabetes?
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What type of exercise is noted to improve tissue sensitivity to insulin in adults with diabetes?
What type of exercise is noted to improve tissue sensitivity to insulin in adults with diabetes?
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What is a characteristic of complex carbohydrates compared to simple carbohydrates?
What is a characteristic of complex carbohydrates compared to simple carbohydrates?
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What is the main focus of nonpharmacologic approaches for managing gestational diabetes?
What is the main focus of nonpharmacologic approaches for managing gestational diabetes?
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Which insulin type has historically been the mainstay for short-acting use in diabetes management?
Which insulin type has historically been the mainstay for short-acting use in diabetes management?
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What should be monitored in women with gestational diabetes mellitus (GDM)?
What should be monitored in women with gestational diabetes mellitus (GDM)?
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What proportion of carbohydrates is suggested to prevent excessive weight gain in women with GDM?
What proportion of carbohydrates is suggested to prevent excessive weight gain in women with GDM?
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What is the recommended composition of a diet for women with GDM regarding protein intake?
What is the recommended composition of a diet for women with GDM regarding protein intake?
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What has recent evidence demonstrated regarding fasting glucose values in women with GDM on a complex carbohydrate diet?
What has recent evidence demonstrated regarding fasting glucose values in women with GDM on a complex carbohydrate diet?
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What aspect of glucose monitoring may change once glucose levels are well controlled by diet?
What aspect of glucose monitoring may change once glucose levels are well controlled by diet?
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What was the conclusion of the randomized trial comparing low-glycemic index and conventional high-fiber diets in women with GDM?
What was the conclusion of the randomized trial comparing low-glycemic index and conventional high-fiber diets in women with GDM?
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What is the usual recommendation for daily glucose measurements in patients with GDM?
What is the usual recommendation for daily glucose measurements in patients with GDM?
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What percentage of total calories is often suggested to consist of fat in the dietary composition for women with GDM?
What percentage of total calories is often suggested to consist of fat in the dietary composition for women with GDM?
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What was the average increase in the diagnosis of gestational diabetes mellitus (GDM) when using the Carpenter and Coustan thresholds compared to other criteria?
What was the average increase in the diagnosis of gestational diabetes mellitus (GDM) when using the Carpenter and Coustan thresholds compared to other criteria?
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Which of the following conditions is associated with an increased risk of adverse perinatal outcomes?
Which of the following conditions is associated with an increased risk of adverse perinatal outcomes?
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Which of the following criteria indicates a woman might have gestational diabetes mellitus according to the information provided?
Which of the following criteria indicates a woman might have gestational diabetes mellitus according to the information provided?
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What additional research area was suggested regarding patients with one abnormal value on the 100-g, 3-hour OGTT?
What additional research area was suggested regarding patients with one abnormal value on the 100-g, 3-hour OGTT?
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Which cholesterol level is specified as a risk factor in relation to gestational diabetes?
Which cholesterol level is specified as a risk factor in relation to gestational diabetes?
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What condition is characterized by women having a prepregnancy body mass index greater than 40 kg/m2?
What condition is characterized by women having a prepregnancy body mass index greater than 40 kg/m2?
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Which of the following groups likely requires further scrutiny during pregnancy?
Which of the following groups likely requires further scrutiny during pregnancy?
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What outcome is highlighted in the study regarding women diagnosed with GDM using the Carpenter and Coustan criteria?
What outcome is highlighted in the study regarding women diagnosed with GDM using the Carpenter and Coustan criteria?
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What is the primary method used to identify gestational diabetes mellitus (GDM)?
What is the primary method used to identify gestational diabetes mellitus (GDM)?
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Which demographic is most likely to have gestational diabetes mellitus diagnosed?
Which demographic is most likely to have gestational diabetes mellitus diagnosed?
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What screening threshold values for the 1-hour glucose challenge test are mentioned?
What screening threshold values for the 1-hour glucose challenge test are mentioned?
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Why might screening low-risk women for GDM be considered inefficient?
Why might screening low-risk women for GDM be considered inefficient?
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What was a significant recommendation made by the U.S. Preventive Services Task Force in 2014 regarding GDM screening?
What was a significant recommendation made by the U.S. Preventive Services Task Force in 2014 regarding GDM screening?
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What are the findings regarding the ideal threshold for screening for gestational diabetes?
What are the findings regarding the ideal threshold for screening for gestational diabetes?
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What was a noted advantage of using a threshold value of 140 mg/dL in screening?
What was a noted advantage of using a threshold value of 140 mg/dL in screening?
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What is the sensitivity improvement expectation when using lower screening thresholds like 130 mg/dL?
What is the sensitivity improvement expectation when using lower screening thresholds like 130 mg/dL?
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Flashcards
What is gestational diabetes mellitus (GDM)?
What is gestational diabetes mellitus (GDM)?
Gestational diabetes mellitus (GDM) is a condition where a woman develops high blood sugar levels during pregnancy.
When does gestational diabetes usually develop?
When does gestational diabetes usually develop?
GDM typically develops between 24 and 28 weeks of gestation.
Why are standardized criteria important for diagnosing GDM?
Why are standardized criteria important for diagnosing GDM?
Standardized diagnostic criteria are recommended for consistency in diagnosing GDM.
What are two examples of GDM diagnostic criteria?
What are two examples of GDM diagnostic criteria?
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Who should use standardized criteria for GDM diagnosis?
Who should use standardized criteria for GDM diagnosis?
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What does the Carpenter and Coustan criteria use to diagnose GDM?
What does the Carpenter and Coustan criteria use to diagnose GDM?
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What does the National Diabetes Data Group criteria use to diagnose GDM?
What does the National Diabetes Data Group criteria use to diagnose GDM?
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What can practices and institutions do while research continues for GDM diagnostic criteria?
What can practices and institutions do while research continues for GDM diagnostic criteria?
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100-g, 3-hour OGTT
100-g, 3-hour OGTT
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Carpenter and Coustan criteria
Carpenter and Coustan criteria
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One abnormal value on the 100-g, 3-hour OGTT
One abnormal value on the 100-g, 3-hour OGTT
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Gestational Diabetes Mellitus (GDM)
Gestational Diabetes Mellitus (GDM)
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Risk factors for GDM
Risk factors for GDM
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Adverse perinatal outcomes
Adverse perinatal outcomes
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Comparative trials
Comparative trials
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Cross-sectional study
Cross-sectional study
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50-gram OGTT
50-gram OGTT
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100-gram OGTT
100-gram OGTT
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GDM Diagnosis
GDM Diagnosis
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GDM Screening Threshold
GDM Screening Threshold
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Optimal GDM Screening Threshold
Optimal GDM Screening Threshold
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Universal GDM Screening
Universal GDM Screening
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GDM Risk Factor Screening
GDM Risk Factor Screening
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What is GDM?
What is GDM?
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What is postprandial hyperglycemia?
What is postprandial hyperglycemia?
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Why is blood glucose monitoring important in GDM?
Why is blood glucose monitoring important in GDM?
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Do we have definitive optimal blood sugar targets for GDM?
Do we have definitive optimal blood sugar targets for GDM?
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What is a low-glycemic index diet?
What is a low-glycemic index diet?
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What is a complex carbohydrate diet?
What is a complex carbohydrate diet?
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What is a suggested dietary composition for managing GDM?
What is a suggested dietary composition for managing GDM?
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Which diet is recommended for GDM?
Which diet is recommended for GDM?
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What are non-pharmacologic treatments for GDM?
What are non-pharmacologic treatments for GDM?
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Dietary changes for GDM
Dietary changes for GDM
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Exercise for GDM management
Exercise for GDM management
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Glucose monitoring in GDM
Glucose monitoring in GDM
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What is long-acting insulin?
What is long-acting insulin?
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Examples of long-acting insulin
Examples of long-acting insulin
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What are insulin analogues?
What are insulin analogues?
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What is short-acting insulin?
What is short-acting insulin?
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Metformin for Gestational Diabetes
Metformin for Gestational Diabetes
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Network Meta-Analysis
Network Meta-Analysis
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Glyburide for Gestational Diabetes
Glyburide for Gestational Diabetes
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Neonatal Hypoglycemia
Neonatal Hypoglycemia
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Macrosomia
Macrosomia
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Risk Ratio (RR)
Risk Ratio (RR)
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Gestational Diabetes
Gestational Diabetes
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Gestational Hypertension
Gestational Hypertension
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Study Notes
Gestational Diabetes Mellitus
- GDM is a condition of carbohydrate intolerance during pregnancy
- It's a common pregnancy complication
- Debate surrounds diagnosis and treatment despite recent studies.
- Aims to provide a brief overview, management guidelines validated by research, and areas needing further research.
Background
- GDM prevalence increases globally due to rising obesity and sedentary lifestyles.
- Prevalence varies by race/ethnicity; highest in Hispanic, African American, Native American, and Asian or Pacific Islander women.
- Risk factors include obesity and increased maternal age, mirroring type 2 diabetes risk factors.
Maternal and Fetal Complications
- Increased risk of preeclampsia (higher risk with glucose > 115mg/dL)
- Increased risk of cesarean delivery (higher risk with medication required for GDM)
- Increased risk of developing type 2 diabetes within 22-28 years after pregnancy (up to 70%).
- Risk factors include ethnicity (e.g., 60% Latin American women within 5 yrs.), obesity, and maternal age.
- Offspring are at higher risk of macrosomia, neonatal hypoglycemia, and birth trauma. A small increased risk of stillbirth exists.
Screening Practices, Diagnostic Thresholds, and Treatment Benefits
- Historical screening focused on past obstetric history and family history of diabetes.
- Current global consensus favors a 75-g, 2-hr OGTT (oral glucose tolerance test) at 24-28 weeks gestation.
- Screening before 24 weeks with elevated glucose is considered for those with pre-existing risk factors like obesity.
- 50-g OGTT is initially used, then a 100-g, 3-hr OGTT if the 50-g result is above the threshold.
- The optimum value for GDM screening remains a subject of debate, but standardized thresholds are recommended for local clinical practice.
Clinical Considerations and Recommendations
- GDM diagnosis requires a laboratory-based blood glucose test, usually at 24-28 weeks.
- A 75-g, 2-hr OGTT is now common and is the standard for diagnosis.
- There is a lack of standardized, optimal threshold values. Consensus favors using one value or another based on risk for the population in need.
- Prioritizing factors such as community prevalence of GDM or resource availability for managing women diagnosed with GDM.
Nonpharmacologic Treatments
- Diet modifications, exercise, and glucose monitoring are the initial treatment options.
- Dietary counseling by a registered dietitian is recommended.
- Nutrition should focus on appropriate caloric allotment, carbohydrate intake, and caloric distribution.
- Exercise goals are 30 minutes of moderate-intensity aerobic exercise most days of the week.
- Daily glucose monitoring (at least 4 times daily, once after fasting and again after meals).
Pharmacologic Treatments
- Insulin is the first-line therapy if blood glucose targets are not met by lifestyle modifications.
- Metformin use is an alternative to insulin, while recognizing its lack of demonstrated superiority and the potential for placental transfer, requiring further study.
- Glyburide is a less preferred medication that exhibits uncertain long-term safety or efficacy relative to insulin.
Delivery Considerations
- Women with well-controlled GDM (diet-only) should ideally be managed expectantly until term (39 weeks).
- Induction of labor (around 38-39 weeks) may provide benefits with respect to reducing some adverse pregnancy outcomes in GDM.
- Fetal surveillance may be beneficial in women with poor glycemic control, and/or other existing high-risk pregnancy factors.
Postpartum Considerations
- Repeat a 75-g, 2-hr OGTT at 4 to 12 weeks postpartum.
- The majority of women achieve adequate glycemic control with lifestyle intervention alone.
- Increased risk of subsequent development of type 2 diabetes exists so long-term surveillance is recommended.
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Description
This quiz provides a concise overview of Gestational Diabetes Mellitus (GDM), including its prevalence, risk factors, and maternal and fetal complications. It also discusses management guidelines and areas for further research regarding this common pregnancy complication. Prepare to test your knowledge on GDM and its impacts!