Gender differences- Dr P

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Questions and Answers

What is the main finding of the analysis of 86 different drugs and more than 5,000 articles?

The dosage given to participants greatly influenced the ADRs

The pharmacokinetics can predict sex differences in adverse drug reactions (ADRs) (correct)

There were no significant differences in ADRs between male and female participants

Female participants had better ADRs than male participants

Which adverse drug reaction (ADR) was NOT mentioned in the text as being suffered more by female participants?

Muscle pain (correct)

Excessive weight gain

Depression

Nausea

What was the proportion of cases where female participants suffered worse ADRs than men?

Around 70%

More than 80%

Less than 50%

Exactly 90% (correct)

What is the focus of the study 'Sex differences in pharmacokinetics: drug reactions in women and male-dominated clinical trials'?

Sex differences in adverse drug reactions (ADRs) Signup and view all the answers

What is the email address of Dr. Fani Papagiannouli mentioned in the text?

<a href="mailto:[email protected]">[email protected]</a> Signup and view all the answers

What was the location mentioned for Dr. Fani Papagiannouli?

Anson 113 Signup and view all the answers

What is the primary goal of the NHS Genomic Medicine Service?

To analyze 500,000 genomes by 2023/24 Signup and view all the answers

What is the purpose of the National Genomic Research Library?

To allow approved researchers to access de-identified data Signup and view all the answers

Why is public education essential in the context of genomics?

To improve community awareness of genetic risk and reduce stigma Signup and view all the answers

What is the role of genetic counseling according to the text?

To help people understand and adapt to genetic contributions to disease Signup and view all the answers

What does genomic equity refer to?

Fair representation and absence of bias in genomic research and clinical analysis Signup and view all the answers

How are ethical issues surrounding gene therapy addressed in the text?

Through continuous discussions to prevent creating 'designer babies' Signup and view all the answers

What is a successful approach to reduce gender bias in clinical practice according to the text?

Ensuring diverse representation in clinical trials Signup and view all the answers

What potential ethical concern is raised by the use of CRISPR/Cas9 technology in the germline according to the text?

Creating unfair advantages and potential long-term consequences for future generations Signup and view all the answers

What is the significance of the UK's unified healthcare system mentioned in the text?

Enables easier data sharing between institutions Signup and view all the answers

What opportunity does the National Genomic Research Library provide according to the text?

Opportunity for researchers, clinicians, healthcare staff, and service providers to access samples, genomic data, and health data. Signup and view all the answers

How can gender bias be reduced in clinical practice according to the text?

Ensuring diverse representation in clinical trials. Signup and view all the answers

What percentage of clinical trials did not report any outcomes by sex, according to a 2011 review?

75% Signup and view all the answers

Which group is often underrepresented in research on HIV/AIDS, chronic kidney diseases, and cardiovascular diseases?

Female participants Signup and view all the answers

Why do researchers often use only male animals in pre-clinical animal studies?

To reduce unnecessary variability Signup and view all the answers

What biases exist in primary care with regard to risk scoring algorithms?

Biases against diverse gender populations Signup and view all the answers

What are some ethical issues surrounding the Human Genome Project?

Privacy and confidentiality Signup and view all the answers

What is important in understanding the response to diet, infection, and different health conditions?

Genomic variation Signup and view all the answers

Which continent has the greatest human genomic variation?

Africa Signup and view all the answers

How many previously undescribed DNA variants were discovered from 426 African individuals in a study by the H3Africa consortium?

3 million Signup and view all the answers

Study Notes

In studies involving drug trials, female participants have suffered worse adverse drug reactions (ADRs) than men in the majority of cases, despite receiving the same dosage. These ADRs include nausea, headaches, drowsiness, depression, excessive weight gain, cognitive deficits, seizures, hallucinations, agitation, and cardiac anomalies.
A 2011 review of clinical trials revealed that 75% did not report any outcomes by sex, and 9 studies had less than 20% female participants. A cross-sectional study of over 43,000 published articles and over 13,000 clinical trials found that female participants were underrepresented, particularly in research on HIV/AIDS, chronic kidney diseases, and cardiovascular diseases.
Researchers often use only male animals in pre-clinical animal studies, fearing the introduction of “unnecessary variability.”
In primary care, biases against diverse gender populations exist. For example, risk scoring algorithms can be used to prioritize patients for transplantations, but these algorithms can disadvantage women due to inaccurate renal function measurements.
Ethical issues surrounding the Human Genome Project include privacy and confidentiality, access to genetic information, and potential uses of genetic testing in employment and education.
Genomic variation is important in understanding the response to diet, infection, and different health conditions. Diversity of reference genomic data is increasing, with Africa being the continent with the greatest human genomic variation.
A study by the Human Heredity and Health in Africa (H3Africa) consortium discovered 3 million previously undescribed DNA variants from 426 African individuals, many of which are in genes linked to various conditions.
In 2020, a Nature article revealed that 45 of 58 studies using data from the UK biobank excluded data from specific populations, with 31 of these studies giving no reason for these exclusions. Small datasets from non-European populations may contribute to less confidence in findings and lead to their exclusion from analysis.
To address these issues and promote community engagement, genomic equity is essential. This includes studying diverse populations, addressing ethical concerns, and ensuring fairness and appropriateness in the use of genomic and genetic technologies.

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Description

Test your knowledge about genomic medicine, healthcare systems, and ethical considerations in the context of integrating genomics into clinical practice. Learn about the UK's approach, the NHS Genomic Medicine Service, and global disparities in healthcare.