Genome-Wide Association Study (GWAS) Purpose
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Questions and Answers

What is the primary purpose of a genome-wide association study (GWAS)?

  • a) To identify rare genetic variants associated with common diseases.
  • b) To analyze the entire genome for associations between genetic variations and traits or diseases. (correct)
  • c) To determine the heritability of specific genetic mutations.
  • d) To sequence the entire genome of an individual.
  • What is the main advantage of imputing additional SNPs in a genome-wide association study?

  • a) It allows for the identification of rare genetic variants.
  • b) It increases the statistical power of the study. (correct)
  • c) It reduces the need for large sample sizes.
  • d) It eliminates the need for genotyping arrays.
  • Which statistical test is commonly used to analyze the association between genetic variants and traits in a genome-wide association study?

  • a) T-test
  • b) Analysis of variance (ANOVA)
  • c) Logistic regression (correct)
  • d) Chi-square test
  • What is the purpose of interpreting findings in a genome-wide association study?

    <p>b) To identify potential therapeutic targets.</p> Signup and view all the answers

    Which step of a genome-wide association study involves identifying specific genetic variations in each individual's DNA sample?

    <p>b) Hybridizing DNA to the array</p> Signup and view all the answers

    In a genome-wide association study, what is the significance level typically used to determine whether an association between a genetic variant and a trait is statistically significant?

    <p>a) p &lt; 0.05</p> Signup and view all the answers

    What is the primary limitation of genome-wide association studies?

    <p>c) They may miss associations with rare genetic variants or gene-environment interactions.</p> Signup and view all the answers

    What is the function of genotyping arrays in a genome-wide association study?

    <p>b) To identify specific genetic variations in each participant's DNA.</p> Signup and view all the answers

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