Genome-Wide Association Study

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what is the purpose of a genome-wide association study?

to scan biomarkers (eg. SNPs) from the DNA of many people to investigate if an SNP contributes to a disease or trait

what do the results of a genome-wide association study show?

if an SNP is overrepresented in cases

what result would show association?

if a certain SNP is more frequent in cases than controls, there is said to be association

what statistical analysis is used to analyse the results of a genome-wide association study?

<p>odds ratio to analyse association and p-value to calculate statistical significance</p> Signup and view all the answers

explain the steps of a genome-wide association study (7 steps)

<ol> <li>gather sample of atleast 1000 cases and 1000 controls</li> <li>collect DNA samples</li> <li>hybridize samples to the array to identify SNPs</li> <li>identify genotypes</li> <li>impute additional SNPs</li> <li>perform statistical analysis</li> <li>interpret findings</li> </ol> Signup and view all the answers