Genetics Chapter on Non-Mendelian Inheritance

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What denotes Non-Mendelian inheritance categories?

Inheritance patterns that do not fall into single gene, chromosomal, or multifactorial categories (correct)
Single gene inheritance only
Inheritance patterns limited to traditional Mendelian examples
Chromosomal and multifactorial inheritance only

What is a key characteristic of trinucleotide repeat expansion?

It causes immediate expression of symptoms after inheritance.
It leads to disease phenotypes through the expansion of specific triplet sequences. (correct)
It involves the deletion of genetic material.
It is only associated with mitochondrial inheritance.

Which of the following diseases is associated with CAG repeat expansion?

Sickle cell disease
Huntington disease (correct)
Down syndrome
Cystic fibrosis

Which statement about mitochondrial inheritance is true?

Only females can pass on mitochondrial diseases to their children. (C) Signup and view all the answers

What is meant by 'anticipation' in the context of trinucleotide repeat expansion?

Symptoms become evident earlier and with more severity in subsequent generations. (C) Signup and view all the answers

Which of the following accurately describes mitochondrial DNA?

It has its own unique set of genes separate from nuclear DNA. (D) Signup and view all the answers

What outcome occurs from an increase in the length of unstable repeats associated with trinucleotide repeat expansion?

It can affect gene expression and lead to disease. (B) Signup and view all the answers

In which type of inheritance are affected fathers unable to pass on the disease?

Mitochondrial inheritance (B) Signup and view all the answers

Non-Mendelian Inheritance

Inheritance patterns that don't follow typical Mendelian rules, often involving factors beyond single genes.

Trinucleotide Repeat Expansion

A type of non-Mendelian inheritance where a repeated sequence of three DNA bases (e.g., CGG, CAG) expands in length.

Anticipation

The increasing severity or earlier onset of a genetic disorder in subsequent generations due to expansion of trinucleotide repeats.

Huntington Disease

A progressive neurological disorder caused by an expanded CAG repeat in the HD gene, leading to involuntary movements, dementia, and emotional problems.

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