Genetics and Migraine Susceptibility

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Questions and Answers

Which of the following is true about the heritability of migraine attacks?

  • Environmental factors have a greater influence on migraine attacks than genetic factors
  • Monozygotic twins have a heritability rate of approximately 50% for migraine attacks (correct)
  • Genetic factors have no influence on the susceptibility to migraine attacks
  • Migraine attacks have a single genetic cause

What is the role of trigger factors in migraine attacks?

  • Trigger factors are not related to genetic factors
  • Trigger factors are the sole cause of migraine attacks
  • Trigger factors modulate the genetic set point that predisposes to migraine headache (correct)
  • Trigger factors have no influence on the occurrence and frequency of migraine attacks

What is the effect of genetic factors on CNS sensitivity to migraine-specific triggers?

  • Genetic factors increase CNS sensitivity to migraine-specific triggers (correct)
  • Genetic factors have no effect on CNS sensitivity to migraine-specific triggers
  • Genetic factors decrease CNS sensitivity to migraine-specific triggers
  • CNS sensitivity to migraine-specific triggers is not influenced by genetic factors

What may be the result of an inherited abnormality in calcium and/or sodium channels and sodium/potassium pumps?

<p>Increased CNS sensitivity to migraine-specific triggers (B)</p> Signup and view all the answers

What is the significance of abnormal recurrence in diagnosing migraine in a patient?

<p>Abnormal recurrence is an important factor in diagnosing migraine (A)</p> Signup and view all the answers

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