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Questions and Answers
What is the main strategy for targeting autosomal dominant genetic diseases using RNA therapies?
What is the main strategy for targeting autosomal dominant genetic diseases using RNA therapies?
- Activating the normal copy of the gene on the partner chromosome
- Enhancing the expression of the defective gene
- Silencing or limiting expression of the pathogenic gene by digesting its mRNA (correct)
- Introducing a normal gene to complement the defective gene
Which type of RNAs is used to control gene function in RNA interference (RNAi)?
Which type of RNAs is used to control gene function in RNA interference (RNAi)?
- mRNAs
- Antisense RNAs
- siRNAs (correct)
- RNA aptamers
What is the role of trans-splicing ribozyme in RNA therapeutics?
What is the role of trans-splicing ribozyme in RNA therapeutics?
- Targeting proteins
- Encoding therapeutic proteins
- Silencing pathogenic genes
- Reprogramming genetic information (correct)
In treating diseases caused by recessive mutations, what is the primary aim of gene therapists?
In treating diseases caused by recessive mutations, what is the primary aim of gene therapists?
Which type of RNA is used in targeting proteins like RNA aptamers in RNA therapies?
Which type of RNA is used in targeting proteins like RNA aptamers in RNA therapies?
What distinguishes RNA interference (RNAi) molecules like siRNAs from other RNA therapeutics?
What distinguishes RNA interference (RNAi) molecules like siRNAs from other RNA therapeutics?
What is the role of siRNAs in the RNA-induced silencing complex (RISC)?
What is the role of siRNAs in the RNA-induced silencing complex (RISC)?
How do aptamers function in cancer therapy?
How do aptamers function in cancer therapy?
What is the role of ribozymes in gene manipulation?
What is the role of ribozymes in gene manipulation?
Which ribozyme group is characterized by self-splicing abilities?
Which ribozyme group is characterized by self-splicing abilities?
What is a unique feature of RNase P ribozyme discovered in E. coli?
What is a unique feature of RNase P ribozyme discovered in E. coli?
Which property distinguishes the hammerhead, hairpin, and HDV ribozyme motifs?
Which property distinguishes the hammerhead, hairpin, and HDV ribozyme motifs?
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