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Genetic Research Methods Glossary

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Questions and Answers

Explain the main focus of Genome-wide Association Research.

Identifying associations between genetic variants and traits across the entire genome.

What is the key difference between Mendelians and Biometricians in their approach to genetic inheritance?

Mendelians explore Mendelian patterns of inheritance in qualitative traits, while Biometricians focus on quantitative traits.

Define Quantitative Genetics and its main purpose.

Investigating natural phenotypic variation by estimating the cumulative genetic influence on traits.

What is the primary focus of Molecular Genetics?

Studying gene function rather than specific phenotypes. Signup and view all the answers

Explain the concept of Polygenic Liability.

Genetic susceptibility to disorders influenced by multiple DNA variants, viewed as a continuous distribution of risk. Signup and view all the answers

Describe Quantitative Traits and how they differ from distinct disorders.

Characteristics influenced by multiple genes, represented as quantitative measurements instead of distinct disorders. Signup and view all the answers

What are Polygenic Risk Scores used for?

Predicting population-wide genetic risk and investigating quantitative trait variations. Signup and view all the answers

Explain the significance of Genome-wide Association Studies (GWA) in understanding disorders.

Identifying associations between genetic variants and traits, aiding in understanding complex disorders through quantitative trait analysis. Signup and view all the answers

What is the focus of Phenomics?

The comprehensive study of phenotypic characteristics at a population level. Signup and view all the answers

How do Multivariate Traits contribute to understanding DNA variants and disorders?

They reveal associations and overlaps between seemingly disparate DNA variants and disorders. Signup and view all the answers

Describe the Dimensional Approach in assessing disorders.

A shift from qualitative diagnoses to quantitative dimensions, allowing a more nuanced understanding of normal trait variation. Signup and view all the answers