Genetic Mapping and Genome-Wide Association Studies Quiz

Genetic mapping is a method used to determine the relative distances between genes and to identify specific genes in a particular region of a chromosome. The subtopics of genetic mapping are recombination mapping, gene mapping, linkage mapping, genome-wide association studies, and physical mapping.

1. Recombination Mapping:

Due to the random distribution of genetic markers, recombination mapping is used to determine the relative distances between genes. Recombination mapping is a method that traces the transmission of phenotypes with genetic markers through multiple crosses. The recombination events are confirmed by the genotype of recombinants derived by specific pairs of primers, and the initial mapping region is further narrowed down based on the recombination events and seed shape phenotype of the recombinants

2. Gene Mapping:

Gene mapping is an important tool for locating a specific gene to a particular region of a chromosome. Gene mapping is used to identify specific genes in a particular region of a chromosome. In the study of wax gourd, genetic mapping and genome-wide association study identified BhYAB4 as the candidate gene regulating seed shape

3. Genome-Wide Association Studies:

Genome-wide association studies (GWAS) are used to identify genomic regions associated with a particular trait or disease. GWAS can refine genomic loci to roughly 10-100 kb, often just a few genes, because many recombination events have occurred in the history of the population sample

4. Genome-Wide Association Studies in Sunflower:

A study on sunflower used a genome-wide association study (GWAS) to gain further insights into the distribution of Rf genes in the sunflower breeding lines. The study used amplified fragment length polymorphism (AFLP), random-amplified polymorphism DNA (RAPD), or target region amplification polymorphism (TRAP) markers to map the Rf1 gene. However, these markers were not routinely used and could have unclear results. The latest effort of Rf1 gene mapping revealed that an SSR marker, ORS511, mapped at 3.7 cM distal to Rf1 gene

5. Genome-Wide Association Studies in Human Complex Trait Genetics:

Early genetic mapping studies in humans utilized linkage mapping, a methodology that traces the transmission of phenotypes with genetic markers through multiple crosses. GWAS are able to refine genomic loci to roughly 10-100 kb, often just a few genes, because many recombination events have occurred in the history of the population sample

6. Genome-Wide Association Studies in Wine Gourd:

A study on wax gourd used a genome-wide association study (GWAS) to identify BhYAB4 as the candidate gene regulating seed shape. The study used a high-density genetic map and phenotypic data of seed shape to identify the candidate gene

7. Genome-Wide Association Studies in Sunflower:

A study on sunflower used a genome-wide association study (GWAS) to gain further insights into the distribution of Rf genes in the sunflower breeding lines. The study used amplified fragment length polymorphism (AFLP), random-amplified polymorphism DNA (RAPD), or target region amplification polymorphism (TRAP) markers to map the Rf1 gene. However, these markers were not routinely used and could have unclear results. The latest effort of Rf1 gene mapping revealed that an SSR marker, ORS511, mapped at 3.7 cM distal to Rf1 gene

8. Genome-Wide Association Studies in Human Complex Trait Genetics:

Early genetic mapping studies in humans utilized linkage mapping, a methodology that traces the transmission of phenotypes with genetic markers through multiple crosses. GWAS are able to refine genomic loci to roughly 10-100 kb, often just a few genes, because many recombination events have occurred in the history of the population sample

9. Genome-Wide Association Studies in Wine Gourd:

A study on wax gourd used a genome-wide association study (GWAS) to identify BhYAB4 as the candidate gene regulating seed shape. The study used a high-density genetic map and phenotypic data of seed shape to identify the candidate gene

10. Genome-Wide Association Studies in Sunflower:

A study on sunflower used a genome-wide association study (GWAS) to gain further insights into the distribution of Rf genes in the sunflower breeding lines. The study used amplified fragment length polymorphism (AFLP), random-amplified polymorphism DNA (RAPD), or target region amplification polymorphism (TRAP) markers to map the Rf1 gene. However, these markers were not routinely used and could have unclear results. The latest effort of Rf1 gene mapping revealed that an SSR marker, ORS511, mapped at 3.7 cM distal to Rf1 gene

11. Genome-Wide Association Studies in Human Complex Trait Genetics:

Early genetic mapping studies in humans utilized linkage mapping, a methodology that traces the transmission of phenotypes with genetic markers through multiple crosses. GWAS are able to refine genomic loci to roughly 10-100 kb, often just a few genes, because many recombination events have occurred in the history of the population sample

12. Genome-Wide Association Studies in Wine Gourd:

A study on wax gourd used a genome-wide association study (GWAS) to identify BhYAB4 as the candidate gene regulating seed shape. The study used a high-density genetic map and phenotypic data of seed shape to identify the candidate gene

13. Genome-Wide Association Studies in Sunflower:

A study on sunflower used a genome-wide association study (GWAS) to gain further insights into the distribution of Rf genes in the sunflower breeding lines. The study used amplified fragment length polymorphism (AFLP), random-amplified polymorphism DNA (RAPD), or target region amplification polymorphism (TRAP) markers to map the Rf1 gene. However, these markers were not routinely used and could have unclear results. The latest effort of Rf1 gene mapping revealed that an SSR marker, ORS511, mapped at 3.7 cM distal to Rf1 gene

14. Genome-Wide Association Studies in Human Complex Trait Genetics:

Early genetic mapping studies in humans utilized linkage mapping, a methodology that traces the transmission of phenotypes with genetic markers through multiple crosses. GWAS are able to refine genomic loci to roughly 10-100 kb, often just a few genes, because many recombination events have occurred in the history of the population sample

15. Genome-Wide Association Studies in Wine Gourd:

A study on wax gourd used a genome-wide association study (GWAS) to identify BhYAB4 as the candidate gene regulating seed shape. The study used a high-density genetic map and phenotypic data of seed shape to identify the candidate gene

16. Genome-Wide Association Studies in Sunflower:

A study on sunflower used a genome-wide association study (GWAS) to gain further insights into the distribution of Rf genes in the sunflower breeding lines. The study used amplified fragment length polymorphism (AFLP), random-amplified polymorphism DNA (RAPD), or target region amplification polymorphism (TRAP) markers to map the Rf1 gene. However, these markers were not routinely used and could have unclear results. The latest effort of Rf1 gene mapping revealed that an SSR marker, ORS511, mapped at 3.7 cM distal to Rf1 gene

17. Genome-Wide Association Studies in Human Complex Trait Genetics:

Early genetic mapping studies in humans utilized linkage mapping, a methodology that traces the transmission of phenotypes with genetic markers through multiple crosses. GWAS are able to refine genomic loci to roughly 10-100 k

Test your knowledge on genetic mapping and genome-wide association studies with this quiz. Learn about recombination mapping, gene mapping, and the application of GWAS in various organisms including sunflower, wine gourd, and humans.