Recombination Mapping and Evolution

Recombination Mapping

• Recombination mapping is a key strategy for locating genomic regions that affect phenotypes.
• It depends on having many well-characterized marker loci of known genomic locations.

Recombination and Evolution

• Recombination is important to evolution because it brings new combinations of genes together upon which natural selection can act.
• Recombination occurs during gamete production (meiosis) if crossover occurs.
• Recombination is the reassortment of genes/alleles into combinations different from those of the parents as a result of independent assortment.

Linkage

• Linkage refers to the closeness of genes on the same chromosome.
• When genes are linked, they are close by and are inherited together.
• Linkage violates Mendel's rules of independent assortment.
• Parentals always have a higher frequency when there is linkage.
• When there is no linkage, there will be equal frequencies.
• Linkage results in a 1:1 ratio.

Genetic Distance vs. Nucleotide Distance

• Genetic distance is measured in centiMorgans.
• Nucleotide distance is measured in base pairs.
• Genetic distance is not equal to nucleotide distance.

This quiz covers the concepts of recombination mapping, its importance in evolution, and the distinction between genetic distance and nucleotide distance.