Genetic Engineering in Cancer Treatment

The main focus of the text is on genetic engineering of mesenchymal stromal cells to express anti-cancer proteins. The potential application is to develop a targeted therapy for cancer treatment with fewer side effects and increased specificity.

Surgery, radiotherapy, chemotherapy, immunotherapy, hormone therapy are mentioned as types of cancer treatment in the text.

The model anti-cancer protein is azurin. It induces tumor cell apoptosis, impairs communication between cancer cells, interferes with tumor cell signaling pathways, and inhibits angiogenesis.

<p>Targeted therapy is described as designed to be more specific with fewer side effects. Its advantages include being designed to be more specific and having fewer side effects.</p> Signup and view all the answers

<p>The challenges mentioned include severe side effects, lack of treatment robustness, and the need for more targeted and effective treatments.</p> Signup and view all the answers

<p>Active Immunity, Passive Immunity, Active Immunization, Passive Immunotherapy, Antibody-Dependent Cell-Mediated Cytotoxicity (ADCC), IgY and single-domain (“nanobodies”) antibodies</p> Signup and view all the answers

<p>The mechanisms of antibiotic resistance dissemination are mentioned in Gupta et al., Environment International, 2020.</p> Signup and view all the answers

<p>The advantages and disadvantages of polyclonal and monoclonal antibodies are discussed in Seixas et al., Vaccines 2022.</p> Signup and view all the answers

<p>Passive Immunization is mentioned in preclinical and clinical trials in Seixas et al., Vaccines 2022.</p> Signup and view all the answers

<p>The source of information for Antibody-Dependent Cell-Mediated Cytotoxicity (ADCC) is mentioned as Merck in the text.</p> Signup and view all the answers