Genetic Engineering in Cancer Treatment

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Explain the main focus of the text and the potential application of genetic engineering in this context.

The main focus of the text is on genetic engineering of mesenchymal stromal cells to express anti-cancer proteins. The potential application is to develop a targeted therapy for cancer treatment with fewer side effects and increased specificity.

What are the types of cancer treatment mentioned in the text?

Surgery, radiotherapy, chemotherapy, immunotherapy, hormone therapy are mentioned as types of cancer treatment in the text.

What is the model anti-cancer protein discussed in the text and what are its effects on tumor cells?

The model anti-cancer protein is azurin. It induces tumor cell apoptosis, impairs communication between cancer cells, interferes with tumor cell signaling pathways, and inhibits angiogenesis.

How is targeted therapy described in the text and what are its advantages?

Targeted therapy is described as designed to be more specific with fewer side effects. Its advantages include being designed to be more specific and having fewer side effects.

What are the challenges associated with current cancer treatments mentioned in the text?

The challenges mentioned include severe side effects, lack of treatment robustness, and the need for more targeted and effective treatments.

What are the different types of immunotherapeutic approaches mentioned in the text to tackle bacterial infections?

Active Immunity, Passive Immunity, Active Immunization, Passive Immunotherapy, Antibody-Dependent Cell-Mediated Cytotoxicity (ADCC), IgY and single-domain (“nanobodies”) antibodies

What are the mechanisms of antibiotic resistance dissemination mentioned in the text?

The mechanisms of antibiotic resistance dissemination are mentioned in Gupta et al., Environment International, 2020.

What are the advantages and disadvantages of polyclonal and monoclonal antibodies discussed in the text?

The advantages and disadvantages of polyclonal and monoclonal antibodies are discussed in Seixas et al., Vaccines 2022.

What types of immunotherapy are used against bacterial infections in preclinical and clinical trials as mentioned in the text?

Passive Immunization is mentioned in preclinical and clinical trials in Seixas et al., Vaccines 2022.

What is the source of information for Antibody-Dependent Cell-Mediated Cytotoxicity (ADCC) mentioned in the text?

The source of information for Antibody-Dependent Cell-Mediated Cytotoxicity (ADCC) is mentioned as Merck in the text.

Test your knowledge of genetic engineering techniques used to modify mesenchymal stromal cells for the expression of anti-cancer proteins. This quiz covers topics such as cancer treatment methods, targeted therapy, and the challenges associated with traditional treatments.

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