Test 7

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Questions and Answers

A young man is brought to the Emergency Department in an anxious and agitated state. He informed the doctor that he had taken a "street drug" that he had injected himself with about 12 hours earlier. After an initial episode of contentment and relaxation, he is now experiencing shaking and muscle pain and vomiting. Its symptoms include hyperventilation and hyperthermia. The doctor notices that his pupils are more dilated than normal. What is the most likely cause of these symptoms?

  • Symptoms and signs are suggestive of opioid withdrawal syndrome (correct)
  • The patient has overdosed on an opioid
  • These are early signs of toxicity resulting from contamination of "street heroin"
  • The patient injected himself with dextroamphetamine
  • The patient has hepatitis B

A 66-year-old female has develops a rash shortly after being started on sulfamethoxazole. Which of the following medications might cause a similar rash in this patient?

  • Naproxen
  • Celecoxib (correct)
  • Aspirin
  • Indomethacin

A 46-year-old man has Cushing's syndrome due to an adrenal tumor. Which of the following drugs can reduce the symptoms of this disease?

  • Ketoconazole (correct)
  • Fludrocortisone
  • Cortisol
  • Betamethasone
  • Triamcinolone

A 39-year-old man presented to the healthcare provider with generalized tonic-clonic seizures. He has a history of epilepsy and has been on carbamazepine for the last 15 years without any seizures. His sister said he recently started taking another medication, but she cannot recall the name. Which of the following drug is the patient most likely taking?

<p>St. John wort (A)</p> Signup and view all the answers

A patient is prescribed heparin sodium 18 units/kg/h with titration according to protocol. The patient weighs 56 kg. Available with heparin 25,000 units/250 ml (100 units/ml). What is the infusion rate in ml/h?

<p>10 ml/h</p> Signup and view all the answers

A 39-year-old woman presents as a new patient for weight loss management. She works as a nursing aide at a long-term care facility. She reports missing several days of work recently due to low back pain flare-ups and is concerned that her coworkers may feel resentful because they are short-staffed on her missed days. She says her weight is "connected" to her low back pain. She informs the clinician that she would like to lose weight. However, she declines a dietician referral, saying, "I've tried lots of different diets, but they never work for me. I gain all of the weight right back." She then asks for additional information regarding weight loss. According to the transtheoretical model of change, this patient is in what stage of change concerning weight loss?

<p>Contemplation (B)</p> Signup and view all the answers

The following graph shows the elimination time course obtained after giving a 320 mg dose of a drug by either i.v. or oral routes. From the data shown, the drugs elimination clearance is:

<p>1.75 L/hr (D)</p> Signup and view all the answers

A 35-year-old woman presents to the clinic with changes in her bowel habits after being prescribed antibiotics for a urinary tract infection. She states her bowels have been loose and greater than 3 times a day. On physical exam, her abdomen appears normal and is non-tender to palpation, and she currently has hyperactive bowel sounds. Which of the following probiotics would be most appropriate for her condition?

<p>Lactobacilli (A)</p> Signup and view all the answers

A 65-year-old man with a past medical history of hypertension, type 2 diabetes, and erectile dysfunction presents to the office for a follow-up. His home medications are metformin and nebivolol. He complains of a dull type of headache that is diffusely present. He denies aura, photophobia, blurry vision, and nasal congestion. He denies any stress at work or in his personal life. His last eye exam was one month ago, and it was completely normal. His vital signs are stable. His physical exam is within normal limits. What is the most likely cause of his headache?

<p>Drug side effect (D)</p> Signup and view all the answers

A 26-year-old construction worker is brought to the emergency department after suffering a lacerated and broken right index finger. Prior to cleansing the wound and applying stitches, the EM physician decides to inject a local anesthetic agent to dull the pain. Which of the following would be contraindicated for use in a local anesthetic solution for this patient's condition?

<p>epinephrine (C)</p> Signup and view all the answers

A 45-year old man who suffered a serious injury to his forearm requires surgery. The patient has a history of poorly controlled hypertension, type 2 diabetes, and angina, which makes the use of general anesthesics unacceptably risky. The anesthesiologist therefore decides to produce a regional block of the axillary brachial plexus with a local anesthetic prior to surgery. However, the patient's medical history indicates a severe allergy to ester-type anesthetics. Which of the following would be the best choice for use in this patient's procedure?

<p>lidocaine (A)</p> Signup and view all the answers

A young patient with bipolar disorder is prescribed risperidone. About which side effect the patient should be informed

<p>Hyperglycemia (A)</p> Signup and view all the answers

Recently widowed 76-year-old woman was treated with benzodiazepines for several weeks after the death of her husband, but did not like the daytime sedation she received even with low doses. She lives independently and has no significant illnesses, but appears frail for her age and has poor eyesight. Since her depressive symptoms are not abating, you decide to prescribe an antidepressant. Which of the following medications is most appropriate for this patient?

<p>Citalopram (B)</p> Signup and view all the answers

A 33-year-old woman tried to induce an abortion by taking ergotamine. She was admitted to the Emergency Department with severe pain in both legs. On examination, her legs are cold and pale, and there is no arterial pulse. Which of the following is an antidote that can reverse the vasospastic effect of ergotamine?

<p>Nitroprusside (B)</p> Signup and view all the answers

A 16-year-old boy with a seizure disorder presents to the hospital with a history of severe joint pain, fever, and fatigue. On examination, he has a low-grade fever, and his vitals are blood pressure 135/85 mmHg, heart rate 89 bpm, and respiratory rate 19 breaths/min. His seizures have been controlled with phenytoin for the past few years. The autoimmune assay is positive for ssDNA, anti-histones, and ANA. What is the most likely diagnosis?

<p>Drug-induced lupus erythematosus (A)</p> Signup and view all the answers

A patient begins treatment with an antiepileptic drug for idiopathic epilepsy and asks how long he will have to take the drug. Which answer is most appropriate?

<p>You will need to take anti-epileptic medicine for the rest of your life (C)</p> Signup and view all the answers

Clarithromycin 0.25 g orally twice a day was prescribed. Clarithromycin oral suspension 125 mg/5 ml is available. How many milliliters should be administered after the medicine is dissolved according to the directions given in the patient leaflet.

<p>10 ml</p> Signup and view all the answers

A researcher wants to evaluate the development of infants with cerebral palsy born to diabetic mothers. The researcher will use the world health organization (WHO) growth standards for boys and girls by collecting information on weight, height, age, and sex. The children will be observed from birth to the age of 5 years. What kind of study is this?

<p>Cohort study (A)</p> Signup and view all the answers

This graph illustrates the dose-response relationship for the effect of the beta agonist isoproterenol on an isolated perfused heart, both alone and in the presence of different fixed concentrations of Drug X. Based upon the data shown, Drug X is most likely a(n):

<p>competitive antagonist (D)</p> Signup and view all the answers

A 28-year-old man presents to his primary care provider for a wellness visit. He states that he is healthy in general and has no complaints. He occasionally drinks 1 or 2 beers and has smoked 10 cigarettes daily for 6 years. He has tried quitting a few times; however, he was unsuccessful. His vitals are temperature 98.0 °F (36.7 °C), blood pressure 124/83 mmHg, heart rate 84 bpm, respirations 11 breaths/min, and oxygen saturation 97% on room air. Physical examination reveals a healthy man with no abnormal findings. The patient asks for help quitting smoking cigarettes, and the provider prescribes a ganglionic cholinergic-receptor agonist in the form of gum to aid the patient in cessation. Which of the following recommendations should be given to this patient regarding medication use?

<p>Discard the gum after 30 minutes and avoid drinking acidic beverages for 1 to 2 hours before chewing the gum. (C)</p> Signup and view all the answers

Flashcards

What is opioid withdrawal syndrome?

A syndrome characterized by physical symptoms like shaking, muscle pain, vomiting, hyperventilation, and hyperthermia, often accompanied by dilated pupils. It typically occurs 6-10 hours after the last opioid dose due to physical dependence on opioid agonists like morphine and heroin.

What is Celecoxib?

A COX-2 inhibitor, a selective NSAID used for pain relief and preventing familial colon polyps. It's structurally similar to sulfonamide drugs and should not be given to patients with severe allergies to sulfonamides due to potential cross-reactivity.

How does Ketoconazole help with Cushing's syndrome?

A potent antifungal medication that inhibits enzymes in the cytochrome P450 system. It can be used to reduce the production of excess glucocorticoids by an adrenal tumor, which is the underlying cause of Cushing's syndrome.

What is cytochrome P 450 3A4?

It is an enzyme involved in the metabolism of the antiepileptic drug Carbamazepine. Inducers of this enzyme, such as St. John's Wort, can lower carbamazepine levels, potentially leading to seizures in patients with epilepsy.

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What is Heparin Sodium used for?

It is a blood thinner (anticoagulant) that prevents blood clots from forming. Its dosage is calculated based on the patient's weight and is typically titrated according to a specific protocol to achieve the desired effect and prevent complications.

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What stage of change is the 39-year-old woman in regarding weight loss?

It is a psychological model that suggests that individuals move through distinct stages when making changes in their behavior. This patient is in the contemplation stage, where she acknowledges the issue of weight loss but lacks a concrete plan for action.

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What is elimination clearance?

It represents a measure of how quickly a drug is eliminated from the body. Clearance is determined using the drug's volume of distribution (Vd) and its elimination half-life (t1/2).

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What are Lactobacilli and why are they helpful?

These are beneficial bacteria that reside in the gut and can help maintain a healthy digestive system. Certain Lactobacilli species are particularly helpful in treating antibiotic-associated diarrhea, which is often caused by the disruption of gut bacteria balance.

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What is Nebivolol and what is one of its common side effects?

It is a beta-1 selective beta blocker medication commonly used to treat high blood pressure. One of its most common side effects is a headache, which is usually diffuse and not accompanied by aura or photophobia.

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Why is epinephrine contraindicated in a local anesthetic solution for a broken and lacerated finger?

It is a vasoconstrictor and can prolong the effects of local anesthetics. However, its use is contraindicated in local anesthetic solutions for extremities like fingers, as it can restrict blood flow and cause tissue hypoxia.

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Why is lidocaine preferred in a regional block for a patient allergic to ester-type anesthetics?

It is an amide local anesthetic, meaning it has a different chemical structure than ester-type anesthetics. This characteristic makes it a safer alternative for patients with severe allergies to ester-type anesthetics.

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What is risperidone and what side effect should patients be informed about?

It is an antipsychotic medication commonly used to treat bipolar disorder. One of the potential side effects that a patient should be informed about is hyperglycemia (elevated blood sugar) due to its potential to impact glucose metabolism.

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Why is Citalopram often preferred for a 76-year-old widow with depression?

It is an SSRI (selective serotonin reuptake inhibitor), commonly used to treat depression. It is often a better choice for older adults compared to other antidepressants that can cause sedation, atropine-like effects, or postural hypotension.

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What is Nitroprusside and how can it help with ergotamine-induced vasoconstriction?

It is a potent vasodilator and is considered a possible antidote to the vasoconstrictive effects of ergotamine. It dilates blood vessels, which can help to improve blood flow and reverse the constriction caused by ergotamine.

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What is drug-induced lupus erythematosus?

It is a type of lupus erythematosus that is induced by certain medications, such as phenytoin, isoniazid, hydralazine, and procainamide. It is characterized by joint pain, fever, fatigue, and positive autoantibodies like ssDNA, antihistones, and ANA.

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Why does someone with epilepsy likely need medication for life?

It is a medical condition characterized by recurrent unprovoked seizures. While the patient will likely need to take antiepileptic medication lifelong, epilepsy itself cannot be cured.

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What is a cohort study?

It is a type of study that follows a group of individuals who share a common characteristic (in this case, being born to diabetic mothers) over time to track how their health outcomes change.

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What is a competitive antagonist?

It is a type of drug interaction characterized by the ability of two drugs to compete for binding to the same receptor site. This results in a rightward shift of the agonist's dose-response curve without changing its maximum efficacy.

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What is nicotine replacement therapy (NRT)?

It is the process of helping an individual stop smoking cigarettes by replacing their nicotine intake with a safer alternative. Nicotine gum, a ganglionic cholinergic-receptor agonist, is one method of NRT, providing a gradual reduction in nicotine dependence.

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What is a ganglionic cholinergic-receptor agonist?

It is a type of drug that activates a specific receptor in the body. Nicotine, a ganglionic cholinergic-receptor agonist found in nicotine gum, activates nicotine receptors in the nervous system, providing a substitute for the nicotine that was previously obtained from cigarettes.

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Why should you avoid acidic beverages before using nicotine gum?

They are acidic drinks, such as coffee or carbonated beverages, that can interfere with the absorption of nicotine from nicotine gum. It is recommended to avoid consuming them for 1 to 2 hours before chewing the gum.

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What is Purple glove syndrome?

It is a common side effect of intravenous phenytoin administration, characterized by a purple discoloration of the hands and feet.

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What is rheumatoid arthritis?

It is an autoimmune disease that affects the joints, leading to pain, swelling, and stiffness. It is associated with certain genetic markers, including HLA-DR4.

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What is drug-induced lupus erythematosus (DILE)?

It is a rare but serious adverse effect that can occur with the use of antiepileptic drugs, specifically phenytoin, as well as other medications. It is characterized by a range of immune system abnormalities.

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What is Mirtazapine?

It is a medication that is used to treat depression and is known for its sedative effects, which can be undesirable for elderly patients. It is generally considered to be a more sedative option compared to SSRIs like Citalopram.

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What is Nebivolol?

It is a medication commonly used to treat high blood pressure and is classified as a beta-blocker, a type of medication that blocks the effects of adrenaline on the heart and blood vessels.

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What are MAOIs?

It is a class of drugs that inhibit the enzyme monoamine oxidase (MAO), which plays a role in the breakdown of certain neurotransmitters like norepinephrine, dopamine, and serotonin. These drugs can interact negatively with foods containing tyramine, potentially leading to a hypertensive crisis.

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What is Sumatriptan?

It is a type of medication that is used to treat migraines and other headaches. It is a selective agonist for serotonin receptors, which are involved in mediating vasoconstriction.

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What is Ondansetron?

It is a type of medication that is used to treat nausea and vomiting. It primarily works by blocking the effects of serotonin in the brain, which plays a role in regulating the vomiting reflex.

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