General Chemistry of Cells
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Questions and Answers

What type of bonds do compounds in the second and third rows contain?

  • Ionic bonds
  • Only single bonds
  • Only triple bonds
  • Double or triple bonds (correct)

What is the interior of every biological membrane primarily composed of?

  • Phospholipid heads
  • Hydrocarbon tails (correct)
  • Proteins
  • Water molecules

What implication does the structure of biological membranes have?

  • They facilitate gas exchange
  • They serve as energy sources
  • They act as permeability barriers (correct)
  • They are reactive to UV light

In which part of the electromagnetic spectrum do ultraviolet, visible, and infrared radiation fall?

<p>A range of wavelengths (B)</p> Signup and view all the answers

Which additional elements are often found in biological compounds beyond carbon and hydrogen?

<p>Oxygen and nitrogen (B)</p> Signup and view all the answers

What is the significance of the dashed lines in the energy and wavelength graph?

<p>They indicate bond energies (D)</p> Signup and view all the answers

What role do hydrocarbons play in biological membranes?

<p>Form structural integrity (B)</p> Signup and view all the answers

Why might more exciting organic compounds be discovered below the surface of Mars?

<p>Less radiation exposure (B)</p> Signup and view all the answers

What type of ions do amines typically behave like in cellular environments?

<p>Sodium ions (D)</p> Signup and view all the answers

Which substance is commonly found in the membranes of animal cells?

<p>Cholesterol (C)</p> Signup and view all the answers

What term describes molecules that have both hydrophilic and hydrophobic regions?

<p>Amphipathic (B)</p> Signup and view all the answers

What kind of molecules are hydrophobic and do not interact with water molecules?

<p>Hydrocarbons (A)</p> Signup and view all the answers

What is a common feature of most membrane lipids and proteins?

<p>They typically have both hydrophilic and hydrophobic regions. (D)</p> Signup and view all the answers

What role do polar groups like hydroxyl or carbonyl play in solubility?

<p>They facilitate hydrogen bonding with water. (B)</p> Signup and view all the answers

Which type of sterol is found in fungal membranes?

<p>Ergosterol (C)</p> Signup and view all the answers

What characteristic do compounds with charged regions and no net charge share?

<p>They are hydrophilic. (C)</p> Signup and view all the answers

What property of water allows some insects to move across a pond without breaking the surface?

<p>High surface tension (A)</p> Signup and view all the answers

Which characteristic of water contributes to its ability to stabilize temperature effectively?

<p>High specific heat capacity (B)</p> Signup and view all the answers

What type of molecules are effectively prevented from entering or escaping from a cell's membrane?

<p>Small, polar molecules (B), Small, charged molecules (C), Large, polar molecules (D)</p> Signup and view all the answers

Which molecules can freely diffuse across membranes regardless of their polarity?

<p>Small, uncharged molecules under molecular weight 100 (D)</p> Signup and view all the answers

What is the specific heat of water per gram to increase its temperature by 1°C?

<p>1.0 calorie (D)</p> Signup and view all the answers

What type of bond is primarily responsible for water’s high surface tension?

<p>Hydrogen bonds (C)</p> Signup and view all the answers

Water is classified as which type of molecule concerning membrane diffusion?

<p>Small uncharged molecule (A)</p> Signup and view all the answers

Which of the following best describes the diffusion behavior of glucose across membranes?

<p>It can diffuse, but to a lesser extent than smaller molecules (D)</p> Signup and view all the answers

Which atom in a water molecule has a partial negative charge?

<p>Oxygen (C)</p> Signup and view all the answers

What is the effect of molecular size on the ability to diffuse across membranes?

<p>Small molecules generally diffuse more easily than large ones (A)</p> Signup and view all the answers

Why do water molecules exhibit extensive association with one another?

<p>Due to hydrogen bonding (B)</p> Signup and view all the answers

How does the polarity of water molecules affect their behavior in liquid or solid states?

<p>It enhances hydrogen bonding (A)</p> Signup and view all the answers

Which property of most cellular constituents limits their ability to cross membranes?

<p>Their polar or charged nature (B)</p> Signup and view all the answers

Which of the following types of molecules have an affinity for membrane interiors?

<p>Small charged molecules (A), Charged ions (C)</p> Signup and view all the answers

Which of the following statements about water's specific heat is true?

<p>It is directly related to hydrogen bonding (D)</p> Signup and view all the answers

Which is true about diffusion of ethanol across cell membranes?

<p>Ethanol diffuses rapidly due to its small size (A)</p> Signup and view all the answers

What is the effect of ion charge on membrane permeability?

<p>Higher charge decreases permeability (A)</p> Signup and view all the answers

Why are small cations like Na+ and K+ significantly less permeable through lipid bilayers?

<p>They are surrounded by a sphere of hydration (B)</p> Signup and view all the answers

What role do transport proteins play in biological membranes?

<p>They facilitate the transfer of ions and polar molecules (B)</p> Signup and view all the answers

What is the primary reason that water can pass through the lipid bilayer more easily than cations?

<p>Water is not charged and has a smaller size (A)</p> Signup and view all the answers

In which state are lipids in the membrane more permeable to water?

<p>Liquid state (C)</p> Signup and view all the answers

What term describes molecules that are not readily permeable through the membrane?

<p>Polar molecules (D)</p> Signup and view all the answers

How much less permeable is a lipid bilayer to small cations compared to water?

<p>108 times less permeable (D)</p> Signup and view all the answers

What characterizes the hydrophobic interior of the membrane?

<p>It is made up of nonpolar tails (C)</p> Signup and view all the answers

Why was it originally believed that animal and plant cells do not share a common nucleus?

<p>There was a lack of understanding of cellular biology. (A)</p> Signup and view all the answers

What was the misunderstanding about the nature of living organisms and the laws of chemistry and physics?

<p>Living organisms are subject to different biological laws. (A)</p> Signup and view all the answers

What was a significant reason for believing that genes consist of proteins instead of DNA?

<p>DNA was believed to be too simple in structure. (C)</p> Signup and view all the answers

Why is it incorrect to state that sunlight is the only source of energy in the biosphere?

<p>Some organisms utilize chemical energy from the environment. (A)</p> Signup and view all the answers

What limitation does traditional light microscopy have regarding cellular structures?

<p>It fails to resolve structures below 200 nm. (A)</p> Signup and view all the answers

What is a misconception regarding fluorescence microscopy?

<p>It can only visualize cells but not their identity. (A)</p> Signup and view all the answers

What was the reasoning behind believing it was impossible to separate individual DNA molecules?

<p>All DNA molecules have similar chemical compositions. (A)</p> Signup and view all the answers

Which of the following is true about the localization of proteins in microscopy?

<p>Localization can confirm protein interactions. (A)</p> Signup and view all the answers

Flashcards

Do animal and plant cells share a nucleus?

The statement that animal and plant cells do not share a common nucleus is incorrect because both types of cells have a nucleus, which houses their genetic material.

Are living organisms subject to different laws than non-living matter?

The statement that living organisms are not governed by the laws of chemistry and physics is false. All matter, living or nonliving, is subject to the same fundamental laws of nature.

What is the genetic material?

The statement that genes are likely made of proteins is incorrect. DNA, though composed of only four nucleotide monomers, carries genetic information and is key to protein synthesis.

Is sunlight the only energy source for life?

The statement that sunlight is the only source of energy in the biosphere is false because some organisms, like deep-sea organisms, rely on energy from chemical reactions rather than sunlight.

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Can you see structures smaller than the wavelength of light?

The statement that the resolution of cellular structures below 200 nm is impossible due to the wavelength of light is false. Techniques like electron microscopy can overcome the light diffraction limit by using beams of electrons.

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Can fluorescence microscopy identify and visualize cells?

Fluorescence microscopy can be used to visualize and identify specific cells and structures due to the ability of fluorescent dyes to specifically bind to certain molecules.

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Can you separate and characterize individual DNA molecules?

It is possible to separate and characterize individual DNA molecules based on size and other properties through techniques like gel electrophoresis, which relies on different DNA fragment migration rates.

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What type of microscopy is being used?

The use of different fluorescent dyes to visualize proteins A and B in C. elegans embryos suggests the use of fluorescence microscopy. The overlay of images suggests potential protein interaction, but further investigation is needed to confirm.

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Energy-Wavelength Relationship

The energy of electromagnetic radiation is inversely proportional to its wavelength. This means shorter wavelengths have higher energy.

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Single Bonds & UV Absorption

Compounds with only single bonds absorb energy in the ultraviolet (UV) region of the electromagnetic spectrum.

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Multiple Bonds & Visible/Infrared Absorption

Compounds with double or triple bonds absorb energy in the visible and infrared regions of the electromagnetic spectrum.

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Hydrocarbon Tails in Membranes

The long hydrocarbon tails of phospholipids create a non-aqueous environment within biological membranes.

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Membrane Function: Permeability Barrier

Biological membranes act as permeability barriers, controlling the movement of substances into and out of cells.

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Common Elements in Biological Compounds

Biological compounds often contain carbon, hydrogen, oxygen, nitrogen, phosphorus, and sulfur.

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Nanometer (nm) Unit

The wavelengths of electromagnetic radiation are measured in nanometers (nm).

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Ethylene & Fruit Ripening

Ethylene gas is used commercially to accelerate fruit ripening.

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Amphipathic Molecules

Molecules with both hydrophobic and hydrophilic regions, like phospholipids in cell membranes.

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Hydrophobic Molecules

Hydrophobic molecules, like hydrocarbons, lack polar regions and don't interact with water molecules.

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Hydrophilic Molecules

Hydrophilic molecules, like those with polar groups (OH, SH, C=O, CHO), interact readily with water due to hydrogen bonding.

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Sterols in Membranes

Sterols, like cholesterol in animal cells, are a type of lipid that helps maintain membrane fluidity.

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Phospholipid Structure

The structure of a membrane phospholipid, like phosphatidylethanolamine, demonstrates its amphipathic nature with a hydrophilic head and hydrophobic tails.

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Amines in Membranes

Amines are protonated at normal cell pH, becoming positively charged and acting like sodium ions in membranes.

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Charged Organic Molecules

Charged organic molecules are typically soluble in water because they interact with water molecules through electrostatic interactions.

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Surface Tension

The tendency of a liquid's surface to resist being broken, due to the strong cohesive forces between its molecules.

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Specific Heat

The amount of heat energy required to raise the temperature of 1 gram of a substance by 1 degree Celsius. It's high for water.

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Hydrogen Bond

A type of bond formed between a hydrogen atom covalently linked to a highly electronegative atom (like oxygen) and an electron pair of a neighboring molecule.

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Polarity

The uneven distribution of electrons in a molecule, resulting in a partial positive charge on one end and a partial negative charge on the other.

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Capillary Action

The ability of water to move upward through the vascular tissues of plants, driven by the cohesive forces between water molecules.

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Diffusion

The movement of molecules from an area of high concentration to an area of low concentration.

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Endocytosis

The process by which cells take in substances from their surroundings, by engulfing them in membrane-bound vesicles.

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Exocytosis

The process by which cells release substances from their interior to the outside, by enclosing them in membrane-bound vesicles.

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Why is selective permeability important for cells?

Cells maintain a specific internal environment by controlling what enters and exits. This selective permeability is essential for life, enabling cells to obtain nutrients, eliminate waste, and maintain their structure and function.

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What type of molecules easily pass through cell membranes?

Molecules with smaller sizes (below 100 molecular weight) can easily pass through cell membranes regardless of polarity, including water.

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How does water move across cell membranes?

Water, despite being polar, readily crosses cell membranes due to its small size, allowing cells to regulate water content.

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What is the effect of size and polarity on membrane permeability?

Large, uncharged polar molecules like glucose have a harder time crossing cell membranes compared to smaller molecules.

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What is the role of membranes in cell function?

Membranes act like barriers, controlling which molecules can enter or leave a cell. This is essential for maintaining the internal environment needed for cellular function.

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How do phospholipids contribute to membrane permeability?

Phospholipids, building blocks of cell membranes, have polar heads (charged) and non-polar tails (uncharged). This duality creates a barrier that controls how molecules pass.

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How do the tails of phospholipids affect membrane barrier function?

The hydrophobic (water-repelling) tails of phospholipids within the membrane create a non-aqueous environment, making it difficult for polar molecules to pass through.

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Why do charged and polar molecules struggle to cross cell membranes?

Charged and polar molecules have a hard time penetrating cell membranes because the membrane interior is non-polar. They require special transport mechanisms to cross.

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Why are ions excluded from the membrane?

The movement of substances across a membrane is regulated by its structure. Specifically, the hydrophobic interior of the lipid bilayer restricts the passage of charged molecules like ions. This is because the ions are surrounded by a sphere of hydration, making it difficult for them to interact with the hydrophobic tails of the membrane.

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Is the lipid bilayer more permeable to water or small ions?

The lipid bilayer is more permeable to water than to small, charged ions like sodium (Na+) and potassium (K+). This is because the hydrophobic environment inside the membrane makes it energetically unfavorable for charged ions to pass through.

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What is the primary function of a biological membrane?

Membranes are crucial for regulating the flow of molecules in and out of cells. They act as selective barriers, allowing some substances to pass through while restricting others.

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How do cells transport molecules across membranes that are not permeable to them?

Transport proteins are embedded within the cell membrane and facilitate the movement of specific molecules across the membrane. They act as channels or carriers, enabling the passage of substances that would otherwise be unable to cross.

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How does the amphipathic nature of phospholipids contribute to the structure of the membrane?

The amphipathic nature of phospholipids is crucial for the formation of the lipid bilayer. The hydrophilic heads face the aqueous environment on either side of the membrane, while the hydrophobic tails form a barrier in the interior.

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Why is the selective permeability of membranes essential for life?

Membranes are highly selective barriers, controlling the movement of substances in and out of cells. This is essential for maintaining cellular homeostasis and ensuring proper function.

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What role does the hydrophobic interior of the lipid bilayer play in membrane permeability?

The hydrophobic interior of the lipid bilayer creates a non-aqueous environment that is unfavorable for charged or polar molecules to cross. This property helps the membrane regulate the passage of various substances.

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How do cells overcome the barrier of the hydrophobic membrane to transport essential molecules?

Cells have evolved specialized transport proteins to facilitate the movement of essential molecules across the membrane. These proteins are essential for maintaining cell function and survival.

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Study Notes

General Chemistry of Cells

  • Cells follow the same laws of chemistry and physics as nonliving matter
  • Organic compounds are formed by the interactions of chemical elements
  • Carbon is the most important element in biological molecules
  • Carbon's valence of four allows it to bond to four other atoms, creating many different types of molecules
  • Carbon-carbon bonds have high bond energies, allowing them to resist breaking during metabolic reactions.
  • Carbon bonds easily to hydrogen, nitrogen, and oxygen atoms.
  • Carbon atoms can form single, double, and triple bonds, creating diverse structures.
  • Carbon atoms can form asymmetric centers, allowing for stereoisomers (molecules with identical connections but different three-dimensional shapes)
  • Water is a polar molecule, meaning one end is slightly positive and one end is slightly negative.
  • Water's polar nature allows it to dissolve many substances.
  • Hydrogen bonding makes water cohesive,
  • Water has a high surface tension.
  • Water has a relatively high specific heat.
  • Water has a high heat of vaporization.

Selectively Permeable Membranes

  • Membranes surround cells and organelles and act as barriers to regulate the passage of materials
  • Membranes are primarily composed of phospholipids, proteins, and carbohydrates
  • The hydrophobic interior of membranes prevents most polar molecules and ions from crossing directly.
  • Small uncharged molecules and water can cross more easily.
  • Transport proteins facilitate the passage of polar molecules and ions
  • The arrangement of phospholipids into a bilayer creates a barrier

Self-Assembly

  • Macromolecules have the intrinsic capacity for spontaneous assembly into complex structures and organelles.
  • The assembly process is driven by noncovalent interactions (hydrogen bonds, ionic bonds, van der Waals forces, and hydrophobic interactions)
  • The arrangement of molecules in a hierarchical manner in cells, from monomers to macromolecules to supramolecular structures, to organelles and finally cells.
  • Noncovalent interactions are essential to the structure and function of macromolecules; they are also responsible for the assembly of larger cellular structures.

Other important facts

  • The process of denaturation leads to the loss of a protein's three-dimensional structure and function
  • Proteins can undergo renaturation in favorable conditions.
  • Molecular chaperones assist in protein folding and assembly.
  • Viruses also exhibit self-assembly.

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Explore the foundational chemistry principles that govern cellular structures and functions. This quiz covers the role of carbon and water in biological molecules, emphasizing their unique properties and interactions within living organisms. Test your understanding of how chemical laws apply to cellular biology.

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