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Questions and Answers

Which of these is NOT a typical symptom of Systemic Lupus Erythematosus (SLE)?

  • Oral ulcers
  • Decreased blood cell count
  • Photosensitivity
  • Increased platelet count (correct)

Which of the following is a common characteristic of SLE?

  • It is a highly contagious disease
  • It primarily affects the digestive system
  • It is more common in men than women
  • It is an autoimmune disease (correct)

What is the primary treatment goal for Systemic Lupus Erythematosus?

  • To cure the disease permanently
  • To manage symptoms and prevent complications (correct)
  • To stimulate the immune system to fight the disease
  • To eradicate the underlying cause of the disease

What is the significance of the SOAPBRAINMD acronym in relation to SLE?

<p>It summarizes the key diagnostic criteria for SLE (B)</p> Signup and view all the answers

Which of the following is a potential trigger for SLE exacerbations?

<p>Stressful life events (B)</p> Signup and view all the answers

How is SLE diagnosed?

<p>A combination of clinical examination, blood tests, and imaging (D)</p> Signup and view all the answers

Which of the following is NOT a common treatment for SLE?

<p>Antibiotics (C)</p> Signup and view all the answers

What is a potential benefit of early SLE diagnosis and treatment?

<p>Improved prognosis and quality of life (D)</p> Signup and view all the answers

Which of the following is a characteristic of a Type IV hypersensitivity reaction?

<p>Delayed response involving T cells and macrophages (B)</p> Signup and view all the answers

What is the primary mechanism behind tissue injury in Type IV hypersensitivity reactions?

<p>Delayed activation of macrophages and T cells (C)</p> Signup and view all the answers

Which of the following hypersensitivity reactions primarily involves the deposition of antigen-antibody complexes?

<p>Type III (D)</p> Signup and view all the answers

Which hypersensitivity reaction does NOT involve antibodies as part of its mechanism?

<p>Type IV (A)</p> Signup and view all the answers

Contact dermatitis is a classic example of which type of hypersensitivity reaction?

<p>Type IV (B)</p> Signup and view all the answers

Which of the following best describes the timing of a Type I hypersensitivity reaction?

<p>Occurs within minutes to hours (A)</p> Signup and view all the answers

What is the primary mediator of Type I hypersensitivity reactions?

<p>IgE (A)</p> Signup and view all the answers

Which of the following is most likely NOT an example of a Type II hypersensitivity reaction?

<p>Contact dermatitis (C)</p> Signup and view all the answers

What is the primary function of B cells in the immune response?

<p>Producing antibodies that target specific antigens (A)</p> Signup and view all the answers

Which type of immunity is developed through vaccination?

<p>Active immunity (C)</p> Signup and view all the answers

What is characteristic of passive immunity?

<p>It involves receiving antibodies from external sources. (C)</p> Signup and view all the answers

What is the primary role of cytotoxic T cells?

<p>Identifying and eliminating infected body cells (B)</p> Signup and view all the answers

Which of the following is a component of the innate immune system?

<p>Skin (D)</p> Signup and view all the answers

What is the key advantage of memory cells in the adaptive immune response?

<p>They lead to a faster response upon subsequent exposure to the same antigen. (A)</p> Signup and view all the answers

Which of these is an example of a physical barrier that provides innate immunity?

<p>Mucous membranes (A)</p> Signup and view all the answers

What type of immunity is given when a baby receives antibodies through breastfeeding?

<p>Passive/natural immunity (D)</p> Signup and view all the answers

What is a characteristic feature of Type 3 von Willebrand's disease?

<p>There is no measurable von Willebrand factor or factor VIII. (C)</p> Signup and view all the answers

Which condition is NOT associated with acquired von Willebrand disease?

<p>Hemophilia A (B)</p> Signup and view all the answers

What form of treatment is typically sufficient for mild cases of von Willebrand's disease?

<p>Bleeding precautions are often enough (B)</p> Signup and view all the answers

What distinguishes Type 2 von Willebrand's disease from other types?

<p>It involves qualitative defects in von Willebrand factor. (C)</p> Signup and view all the answers

Which statement regarding Type 1 von Willebrand's disease is correct?

<p>It is the commonest form with a partial deficiency of von Willebrand factor. (A)</p> Signup and view all the answers

Which sign is typically not a positive indication of systemic lupus erythematosus (SLE)?

<p>Proper platelet count with testing (B)</p> Signup and view all the answers

What is the primary type of HIV that is most commonly found in the USA?

<p>Type 1 (C)</p> Signup and view all the answers

What is a common cause of immunodeficiency classified as secondary?

<p>Chronic viral infection (C)</p> Signup and view all the answers

Which characteristic best describes the asymptomatic phase of HIV?

<p>Virus reproducing for several years (D)</p> Signup and view all the answers

Which of the following is a known route of HIV transmission?

<p>Sharing needles (B)</p> Signup and view all the answers

In SLE, which blood count abnormality is commonly observed?

<p>Leukopenia (B)</p> Signup and view all the answers

Which type of HIV progresses to disease more slowly and is more common in West Africa?

<p>Type 2 (D)</p> Signup and view all the answers

What role do probiotics play in the context of immunodeficiency?

<p>Help increase normal flora (A)</p> Signup and view all the answers

What is the primary characteristic of abnormal B lymphocytes in the context of lymphoma?

<p>They are much larger than normal lymphocytes. (C)</p> Signup and view all the answers

What stage of Hodgkin's lymphoma is characterized by the presence of lymphoma cells in lymph nodes above and below the diaphragm?

<p>Stage III (C)</p> Signup and view all the answers

Which of the following is a common manifestation of lymphoma?

<p>Weight loss (B)</p> Signup and view all the answers

What type of leukemia primarily affects children and typically has a good prognosis?

<p>Acute lymphoblastic leukemia (D)</p> Signup and view all the answers

What is a key diagnostic feature of Hodgkin's lymphoma?

<p>Presence of Reed-Sternberg cells in a lymph node biopsy (C)</p> Signup and view all the answers

Which type of lymphoma does NOT contain Reed-Sternberg cells?

<p>Non-Hodgkin's lymphoma (C)</p> Signup and view all the answers

What is a common risk factor associated with the development of leukemia?

<p>Exposure to chemical and radiation mutagens (B)</p> Signup and view all the answers

What symptom is specifically associated with multiple myeloma?

<p>Hypercalcemia (D)</p> Signup and view all the answers

What is the most common treatment approach for leukemia?

<p>Chemotherapy and bone marrow transplant (A)</p> Signup and view all the answers

Which type of leukemia is most common in adults?

<p>Chronic myeloid leukemia (D)</p> Signup and view all the answers

Flashcards

B cells

A type of immune cell that plays a role in the adaptive immune response by producing antibodies that target specific pathogens.

Cytotoxic T cells

A type of white blood cell that is part of the adaptive immune system and helps to fight off infections by killing infected cells.

Adaptive immunity

A type of immune response that is characterized by being specific to a particular pathogen and involving memory cells.

Innate immunity

A type of immunity that is non-specific to a particular pathogen and is present from birth.

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Passive immunity

A type of immunity that is acquired by receiving antibodies from external sources, such as through maternal-fetal transfer or breastfeeding.

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Active immunity

A type of immunity that is acquired by having the disease or by vaccination.

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Immunity

The ability of the body to fight off infection and disease.

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Memory cells

Specialized cells that are produced during an immune response and can quickly recognize and respond to a specific pathogen upon subsequent exposure.

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Type IV Hypersensitivity

A delayed hypersensitivity reaction that involves T cells rather than antibodies, primarily involving macrophages and T cells, leading to severe tissue damage and fibrosis.

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Antigen Presentation in Type IV

The antigen is presented to T cells, initiating a delayed response involving macrophages and T cells.

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Severe Tissue Injury and Fibrosis

The result of Type IV hypersensitivity reactions, which primarily involve macrophages and T cells, leading to inflammation and tissue damage.

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Tuberculin Skin Test

A classic example of Type IV hypersensitivity reaction, where exposure to tuberculin protein leads to a localized inflammatory reaction, usually a small red bump.

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Transplant Reactions

A response by the body to the presence of transplanted foreign tissue, involving the rejection of the transplant by the immune system.

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Contact Dermatitis

An allergic reaction that involves contact with certain substances such as poison ivy, nickel, or latex, resulting in skin rash, itching, and inflammation.

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Antigen Recognition and Presentation

The process by which the immune system recognizes and responds to antigens. In Type IV hypersensitivity, antigen presentation to T cells triggers a delayed and cell-mediated immune response.

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Cell-Mediated Immunity in Type IV

The immune system's response to antigens involving various effector cells, namely T cells, and their products like cytokines, ultimately leading to the elimination of the antigen.

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Malar Rash

A butterfly-shaped rash across the cheeks and nose, often a key characteristic of SLE.

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Systemic Lupus Erythematosus (SLE)

A condition where the body's immune system attacks its own tissues and organs, leading to inflammation and damage.

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Leukopenia

A decrease in the number of white blood cells in the blood, common in SLE.

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Joint Inflammation in SLE

Inflammation and pain in the joints, a frequent symptom of SLE.

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Immunodeficiency

A state of weakened immune system, making individuals susceptible to infections.

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Opportunistic Infections

Infections that occur in individuals with compromised immune systems.

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HIV (Human Immunodeficiency Virus)

A parasitic retrovirus that infects CD4 cells and macrophages, leading to the development of AIDS.

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AIDS (Acquired Immunodeficiency Syndrome)

The final stage of HIV infection, characterized by severely weakened immune system and susceptibility to opportunistic infections.

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Exacerbation (SLE)

Periods of active disease, with symptoms present, characterized by elevated inflammation, joint pain, and potential organ damage.

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Remission (SLE)

Periods of inactivity, with minimal or no symptoms, in SLE where inflammation and organ damage are reduced.

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Polyarthritis

A type of arthritis found in SLE where multiple joints are swollen, sensitive, and painful.

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Antinuclear Antibody (ANA)

Positive antibody testing in SLE. Abnormal antibodies are found in the blood.

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Discoid Lupus (DLE)

A subtype of lupus where the skin is affected, causing red, scaly patches that can leave scars.

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Serositis

A diagnostic criterion for SLE, often present in the lining around the heart, abdominal, and thoracic cavities.

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What is Type 3 von Willebrand's disease?

An inherited disorder where there is an almost complete absence of von Willebrand factor, leading to more severe bleeding.

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What is Type 2 von Willebrand's disease?

This type of disease involves a qualitative defect in von Willebrand factor, meaning that the factor does not function properly.

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What is Type 1 von Willebrand's disease?

This is the mildest and most common form of the disorder.

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What is Acquired von Willebrand's disease?

This form of the disease is not inherited. It develops due to other conditions, such as heart disease, certain cancers, or autoimmune disorders.

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How is von Willebrand's disease diagnosed?

Bleeding studies assess the clotting time and factor VIII levels.

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Hodgkin's Lymphoma

A type of lymphoma characterized by the presence of Reed-Sternberg cells, which are abnormal B lymphocytes.

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Non-Hodgkin's Lymphoma

A type of lymphoma characterized by the absence of Reed-Sternberg cells and a wider variety of abnormal B lymphocytes.

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Stage III Hodgkin's Lymphoma

Stage III Hodgkin's Lymphoma involves lymph nodes both above and below the diaphragm, potentially affecting tissue, organs, and the spleen.

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Leukemia

A type of cancer that affects the leukocytes (white blood cells), leading to abnormal proliferation and crowding of normal blood cells.

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Acute Lymphoblastic Leukemia (ALL)

A type of leukemia that primarily affects children, responding well to therapy and offering a good prognosis.

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Acute Myeloid Leukemia (AML)

A type of leukemia that primarily affects adults, responding fairly well to treatment with a somewhat worse prognosis than ALL.

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Chronic Lymphoid Leukemia (CLL)

A type of leukemia that primarily affects adults, responding poorly to therapy but allowing many years of survival after diagnosis.

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Chronic Myeloid Leukemia (CML)

A type of leukemia that primarily affects adults, responding poorly to chemotherapy but improving with a bone marrow transplant.

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Multiple Myeloma

A cancer of the plasma cells that leads to excessive production of abnormal plasma cells in the bone marrow.

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Bence Jones Proteins

A protein found in the urine of patients with Multiple Myeloma, indicative of the disease.

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