Gene Structure and Domain Determination Quiz
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Questions and Answers

What can start codons, TATA boxes, and polyA addition sites determine?

  • UTRs
  • Exons (correct)
  • Codon biases
  • Introns

What is a common indicator of transmembrane segments in proteins?

  • Polar side chains
  • Short alpha helices
  • Aromatic residues at the ends of helices (correct)
  • Loose packing of helices

What can the presence of S-S bonds or metal ions indicate about a protein domain?

  • The domain is highly polar
  • The domain is stabilized (correct)
  • The domain has introns
  • The domain is hydrophobic

Which feature is typical of low complexity segments in protein sequences?

<p>Presence of overlapping repeats (C)</p> Signup and view all the answers

What does the dotplot method help detect in protein sequences?

<p>Transmembrane segments (D)</p> Signup and view all the answers

Why can topography and the presence of multiple segments be challenging for predicting transmembrane proteins?

<p>They complicate the identification of segment boundaries (D)</p> Signup and view all the answers

What is an indicator that an alpha-helix has been broken?

<p>Proline is an alpha-helix breaker (A)</p> Signup and view all the answers

What is one issue with loops?

<p>Disorganized, hard to predict because they are less conserved, may not interact with other proteins (A)</p> Signup and view all the answers

How do we predict secondary structures?

<p>Alpha Fold (neural network method) (C)</p> Signup and view all the answers

What does Ramachandran plot do?

<p>Determines possible torsion angles that are energetically favorable (B)</p> Signup and view all the answers

How are force fields created?

<p>Energy levels used to create a force field of possible rotations. Lowest energy state is native structure typically (D)</p> Signup and view all the answers

What can force fields do?

<p>Calculate the potential energy of a conformational state which may include molecules such as solvents (B)</p> Signup and view all the answers

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