Podcast
Questions and Answers
What is the primary function of genes within the context of cellular activity?
What is the primary function of genes within the context of cellular activity?
- To facilitate the transport of molecules across the cell membrane.
- To control the synthesis of proteins. (correct)
- To directly produce energy for cellular processes.
- To directly regulate cell division.
Which of the following is a correct base pairing in DNA?
Which of the following is a correct base pairing in DNA?
- Guanine bonds with Cytosine (correct)
- Adenine bonds with Guanine
- Cytosine bonds with Thymine
- Thymine bonds with Guanine
What constitutes a codon in the genetic code?
What constitutes a codon in the genetic code?
- Three successive nucleotide bases. (correct)
- Four successive nucleotide bases.
- A single nucleotide base.
- Two successive nucleotide bases.
What is the role of RNA in protein synthesis?
What is the role of RNA in protein synthesis?
Where does transcription occur within the cell?
Where does transcription occur within the cell?
Which cellular structure is responsible for the actual assembly of proteins from the messenger RNA template?
Which cellular structure is responsible for the actual assembly of proteins from the messenger RNA template?
What are the building blocks of Deoxyribonucleic acid?
What are the building blocks of Deoxyribonucleic acid?
Where are ribosomal proteins formed?
Where are ribosomal proteins formed?
What is the primary function of ribosomes attached to the rough endoplasmic reticulum?
What is the primary function of ribosomes attached to the rough endoplasmic reticulum?
Which of the following is NOT a direct function of protein enzymes produced in cells?
Which of the following is NOT a direct function of protein enzymes produced in cells?
What is a defining characteristic of enzyme regulation?
What is a defining characteristic of enzyme regulation?
What is the primary function of genetic regulation?
What is the primary function of genetic regulation?
How does the cell cycle of a rapidly reproducing cell typically end?
How does the cell cycle of a rapidly reproducing cell typically end?
What does 'semi-conservative' describe in the context of DNA replication?
What does 'semi-conservative' describe in the context of DNA replication?
What is the role of 'proofreading' in DNA replication?
What is the role of 'proofreading' in DNA replication?
How does cell size directly relate to the nucleus?
How does cell size directly relate to the nucleus?
What is selective repression of gene promoters responsible for in regards of development?
What is selective repression of gene promoters responsible for in regards of development?
What is the key distinction between apoptosis and necrosis?
What is the key distinction between apoptosis and necrosis?
What normally prevents tissues from shrinking or growing excessively?
What normally prevents tissues from shrinking or growing excessively?
What is the PRIMARY cause of cancer at the cellular level?
What is the PRIMARY cause of cancer at the cellular level?
Why do most mutated cells not lead to cancer?
Why do most mutated cells not lead to cancer?
What is a typical immune system response to mutated cells?
What is a typical immune system response to mutated cells?
What is the role of hormones in cellular function?
What is the role of hormones in cellular function?
What factor must be present simultaneously for cancer to develop according to the content?
What factor must be present simultaneously for cancer to develop according to the content?
Which of the following is identified as the most significant carcinogen leading to cancer deaths?
Which of the following is identified as the most significant carcinogen leading to cancer deaths?
How does ionizing radiation contribute to cancer development?
How does ionizing radiation contribute to cancer development?
What is a characteristic behavior of cancer cells compared to normal cells?
What is a characteristic behavior of cancer cells compared to normal cells?
Which of the following factors can increase the probability of mutations leading to cancer?
Which of the following factors can increase the probability of mutations leading to cancer?
What role do oncoviruses like hepatitis B and C play in cancer development?
What role do oncoviruses like hepatitis B and C play in cancer development?
What effect can cancer cells have on vital organ function?
What effect can cancer cells have on vital organ function?
What is the relationship between cancer cells and blood vessel growth?
What is the relationship between cancer cells and blood vessel growth?
Flashcards
What is the structure of DNA?
What is the structure of DNA?
The structure of DNA consists of alternating phosphate groups and deoxyribose molecules forming the backbone, with nitrogenous bases (adenine, guanine, thymine, and cytosine) attached to the deoxyribose molecules. Adenine always pairs with thymine, and guanine always pairs with cytosine.
What is a codon?
What is a codon?
The genetic code is a sequence of three consecutive DNA bases called a 'triplet' or 'codon'. Each triplet codes for a specific amino acid, ultimately determining the sequence of amino acids in a protein.
What is transcription?
What is transcription?
Transcription is the process of copying the genetic code from DNA to messenger RNA (mRNA). This occurs in the nucleus, where DNA stays, and the mRNA diffuses out into the cytoplasm.
What is translation?
What is translation?
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Where are ribosomes located?
Where are ribosomes located?
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What is the role of mRNA?
What is the role of mRNA?
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What are genes?
What are genes?
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How do genetic diseases arise?
How do genetic diseases arise?
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Cancer Development - Multiple Gene Requirement
Cancer Development - Multiple Gene Requirement
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Cancer Risk Genes: Reproduction & Blood Vessels
Cancer Risk Genes: Reproduction & Blood Vessels
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Mutation Probability Increase
Mutation Probability Increase
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Carcinogens
Carcinogens
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Hereditary Cancer Tendency
Hereditary Cancer Tendency
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Cancer Cell Adhesion
Cancer Cell Adhesion
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Cancer Angiogenesis
Cancer Angiogenesis
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Cancer's Nutritional Impact
Cancer's Nutritional Impact
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Cellular Regulation
Cellular Regulation
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Genetic Regulation
Genetic Regulation
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Enzyme Regulation
Enzyme Regulation
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Feedback Inhibition
Feedback Inhibition
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Mitosis
Mitosis
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DNA Replication
DNA Replication
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Mutations
Mutations
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Cell Differentiation
Cell Differentiation
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Apoptosis
Apoptosis
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Cancer
Cancer
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Proofreading
Proofreading
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Necrosis
Necrosis
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DNA
DNA
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Transcription
Transcription
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Translation
Translation
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Study Notes
Gene Structure and Function
- Genes influence all aspects of body structure and function
- Genes are composed of DNA, a long double helix molecule
- DNA building blocks: phosphoric acid, deoxyribose, and nitrogenous bases (adenine, guanine, thymine, cytosine)
- DNA backbone: alternating phosphoric acid and deoxyribose molecules
- Nitrogenous bases pair: adenine with thymine, guanine with cytosine
- Genetic code: successive triplet bases (three bases = one code word)
- Triplet bases control amino acid sequence in proteins
Protein Synthesis
- Transcription: DNA code transferred to RNA in the nucleus
- RNA diffuses from nucleus to cytoplasm
- DNA stays in nucleus
- Multiple RNA types exist (messenger, transfer, ribosomal) with varied functions
- Ribosomes are formed in cytoplasm, not nucleus
- Translation: Protein formation in ribosomes
- Ribosomes read messenger RNA, producing protein chains
- Single mRNA can be read by multiple ribosomes simultaneously
- Rough endoplasmic reticulum (ER) involved in protein synthesis and transport
Gene Regulation
- Genetic regulation controls protein synthesis from transcription to protein formation
- Different cells express different genes despite shared genetic code (e.g., cardiac vs. epithelial cells)
- Enzyme regulation: Control mechanisms to regulate enzyme activity
- Activator or inhibitor substances (e.g., hormones) can increase/decrease enzyme activity
- Two Principal Mechanisms:
- Genetic regulation (activating/inhibiting genes)
- Enzyme regulation (activating/inhibiting enzymes)
Cell Reproduction
- Genes control cell growth and division (mitosis)
- Cell life cycles vary (10-30 hours for some cells; lifetime for others; Bone marrow cells, smooth muscle cells, neurons)
- Cell Replication (DNA): DNA replicates into two identical strands (semi-conservative method)
- Proofreading & Mutation: Enzymes correct replication errors; mutations result from undetected errors
Cell Death and Cancer
- Apoptosis: Programmed cell death; cells shrink, condense, and are then digested.
- Contrast with necrosis (cell swelling and bursting)
- Cancer: Caused by mutations (among other factors) in cellular genes that regulate growth & mitosis
- Most mutated cells die
- Cancer develops when mutated cells evade normal feedback controls, evade immune system, or develop angiogenic factors
Cancer Development Factors
- Mutations in multiple genes required for cancer development
- Environmental factors (e.g., radiation, chemical exposure) increase mutation chances.
- Hereditary tendencies reduce the number of required mutations by inheriting pre-cancerous genes
- Viruses (e.g., hepatitis B, C, HIV) can increase the risk of cancer
- Invasive characteristics: Cancer cells tend to detach, move, and metastasize.
- Competition for nutrients, disruption of organ function
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