2.1 Gene Structure and Protein Synthesis Quiz

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Questions and Answers

What is the primary function of genes within the context of cellular activity?

  • To facilitate the transport of molecules across the cell membrane.
  • To control the synthesis of proteins. (correct)
  • To directly produce energy for cellular processes.
  • To directly regulate cell division.

Which of the following is a correct base pairing in DNA?

  • Guanine bonds with Cytosine (correct)
  • Adenine bonds with Guanine
  • Cytosine bonds with Thymine
  • Thymine bonds with Guanine

What constitutes a codon in the genetic code?

  • Three successive nucleotide bases. (correct)
  • Four successive nucleotide bases.
  • A single nucleotide base.
  • Two successive nucleotide bases.

What is the role of RNA in protein synthesis?

<p>To carry the genetic code from DNA to the ribosome. (C)</p> Signup and view all the answers

Where does transcription occur within the cell?

<p>In the nucleus. (A)</p> Signup and view all the answers

Which cellular structure is responsible for the actual assembly of proteins from the messenger RNA template?

<p>The ribosome. (A)</p> Signup and view all the answers

What are the building blocks of Deoxyribonucleic acid?

<p>Phosphoric acid, deoxyribose, and nitrogenous bases (D)</p> Signup and view all the answers

Where are ribosomal proteins formed?

<p>In cytoplasm of the cell (D)</p> Signup and view all the answers

What is the primary function of ribosomes attached to the rough endoplasmic reticulum?

<p>Producing proteins that enter the reticulum matrix (D)</p> Signup and view all the answers

Which of the following is NOT a direct function of protein enzymes produced in cells?

<p>Regulating the transcription process in the nucleus (B)</p> Signup and view all the answers

What is a defining characteristic of enzyme regulation?

<p>It relies on negative feedback to control substance synthesis (C)</p> Signup and view all the answers

What is the primary function of genetic regulation?

<p>To manage the quantities and proportions of cellular components (C)</p> Signup and view all the answers

How does the cell cycle of a rapidly reproducing cell typically end?

<p>Through mitosis, cell division into two daughter cells (A)</p> Signup and view all the answers

What does 'semi-conservative' describe in the context of DNA replication?

<p>The method of replication where half of each new DNA molecule comes from the original DNA (C)</p> Signup and view all the answers

What is the role of 'proofreading' in DNA replication?

<p>To correct any defective areas of the DNA molecule (C)</p> Signup and view all the answers

How does cell size directly relate to the nucleus?

<p>The amount of functional DNA in the nucleus determines the cell size (D)</p> Signup and view all the answers

What is selective repression of gene promoters responsible for in regards of development?

<p>The differentiation process that leads to different cell types (C)</p> Signup and view all the answers

What is the key distinction between apoptosis and necrosis?

<p>Apoptosis is a planned cell death, while necrosis results from cell injury (C)</p> Signup and view all the answers

What normally prevents tissues from shrinking or growing excessively?

<p>Controlled balance between programmed cell death and new cell formation (A)</p> Signup and view all the answers

What is the PRIMARY cause of cancer at the cellular level?

<p>Uncontrolled cell mutation and abnormal activation of cellular growth (B)</p> Signup and view all the answers

Why do most mutated cells not lead to cancer?

<p>Mutated cells often have decreased survivability and normal feedback controls in place. (D)</p> Signup and view all the answers

What is a typical immune system response to mutated cells?

<p>The immune system recognizes and destroys most cells that have abnormal proteins. (B)</p> Signup and view all the answers

What is the role of hormones in cellular function?

<p>Control intracellular biochemical reactions by activating or inhibiting control systems (D)</p> Signup and view all the answers

What factor must be present simultaneously for cancer to develop according to the content?

<p>At least two genes, one for rapid reproduction and one for blood vessel formation (D)</p> Signup and view all the answers

Which of the following is identified as the most significant carcinogen leading to cancer deaths?

<p>Cigarette smoke (C)</p> Signup and view all the answers

How does ionizing radiation contribute to cancer development?

<p>It ruptures DNA strands, causing mutations (B)</p> Signup and view all the answers

What is a characteristic behavior of cancer cells compared to normal cells?

<p>They proliferate indefinitely and consume nutrients (D)</p> Signup and view all the answers

Which of the following factors can increase the probability of mutations leading to cancer?

<p>Exposure to certain chemical, physical, and biological factors (A)</p> Signup and view all the answers

What role do oncoviruses like hepatitis B and C play in cancer development?

<p>They increase the risk of developing cancer (D)</p> Signup and view all the answers

What effect can cancer cells have on vital organ function?

<p>They can replace normal tissue, hindering organ function (B)</p> Signup and view all the answers

What is the relationship between cancer cells and blood vessel growth?

<p>Cancer cells can produce angiogenic factors to stimulate new blood vessels (D)</p> Signup and view all the answers

Flashcards

What is the structure of DNA?

The structure of DNA consists of alternating phosphate groups and deoxyribose molecules forming the backbone, with nitrogenous bases (adenine, guanine, thymine, and cytosine) attached to the deoxyribose molecules. Adenine always pairs with thymine, and guanine always pairs with cytosine.

What is a codon?

The genetic code is a sequence of three consecutive DNA bases called a 'triplet' or 'codon'. Each triplet codes for a specific amino acid, ultimately determining the sequence of amino acids in a protein.

What is transcription?

Transcription is the process of copying the genetic code from DNA to messenger RNA (mRNA). This occurs in the nucleus, where DNA stays, and the mRNA diffuses out into the cytoplasm.

What is translation?

Translation is the process of interpreting the mRNA code into a protein. Ribosomes, which are cellular structures found in the cytoplasm, read the mRNA codons and link together amino acids in the correct order.

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Where are ribosomes located?

Ribosomes are essential cellular structures that act as manufacturing plants for protein synthesis. They are located in the cytoplasm and do not exist in the nucleus.

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What is the role of mRNA?

Messenger RNA (mRNA) carries the genetic code from DNA to ribosomes, where it directs protein synthesis.

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What are genes?

Genes are segments of DNA that carry the instructions for building and maintaining an organism. They control the production of proteins, which in turn determine the characteristics of an individual.

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How do genetic diseases arise?

Genetic diseases arise from defects in genes, disrupting normal protein function. These defects can lead to various health issues, depending on the specific gene affected.

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Cancer Development - Multiple Gene Requirement

The chance of developing cancer is significantly increased, sometimes fivefold, when several specific genes are present simultaneously.

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Cancer Risk Genes: Reproduction & Blood Vessels

A gene that promotes rapid cell reproduction, combined with a gene that triggers blood vessel formation, can create a higher risk for cancer development.

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Mutation Probability Increase

Although mutations occur naturally, their probability increases significantly in the presence of specific factors, such as exposure to chemicals, radiation, and other agents.

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Carcinogens

Substances that trigger or promote cancer development, like cigarette smoke, are known as carcinogens.

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Hereditary Cancer Tendency

Hereditary cancer suggests that one or more genes responsible for cancer development are already mutated in the inherited genome, requiring fewer additional mutations to initiate cancer.

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Cancer Cell Adhesion

Cancer cells often exhibit a reduced ability to adhere to each other, allowing them to break free and spread to other tissues through the bloodstream or lymphatic system.

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Cancer Angiogenesis

Cancer cells stimulate the growth of new blood vessels, providing them with a direct supply of nutrients and oxygen, aiding in their continued growth and spread.

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Cancer's Nutritional Impact

Cancer cells can outcompete normal cells for essential nutrients, eventually depriving vital organs and disrupting their functions, as seen in lung cancer where oxygen absorption is impaired.

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Cellular Regulation

The process by which cells control the production of proteins and other substances.

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Genetic Regulation

The mechanism by which cells control the expression of genes, turning them on or off.

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Enzyme Regulation

The regulation of enzyme activity, controlling their ability to catalyze specific reactions.

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Feedback Inhibition

A type of cellular control where the product of a reaction inhibits the enzyme that catalyzes the reaction, creating a negative feedback loop.

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Mitosis

The process by which a cell divides into two identical daughter cells.

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DNA Replication

The process of duplicating the cell's DNA before cell division.

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Mutations

Errors that occur during DNA replication, leading to changes in the genetic code.

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Cell Differentiation

The process by which cells specialize for different functions, resulting in diverse cell types in the body.

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Apoptosis

The process of programmed cell death, a controlled and orderly process of cell dismantling.

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Cancer

Uncontrolled cell growth and division, often caused by mutations in genes that regulate cell cycle.

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Proofreading

A period of time between DNA replication and mitosis during which DNA is proofread and errors are corrected.

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Necrosis

A type of cell death caused by injury or damage, resulting in cell swelling and bursting.

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DNA

The genetic material of a cell, containing instructions for all cellular functions.

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Transcription

The process by which DNA is used as a template to create RNA, a molecular message that carries genetic information.

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Translation

The synthesis of proteins based on the instructions carried by RNA.

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Study Notes

Gene Structure and Function

  • Genes influence all aspects of body structure and function
  • Genes are composed of DNA, a long double helix molecule
  • DNA building blocks: phosphoric acid, deoxyribose, and nitrogenous bases (adenine, guanine, thymine, cytosine)
  • DNA backbone: alternating phosphoric acid and deoxyribose molecules
  • Nitrogenous bases pair: adenine with thymine, guanine with cytosine
  • Genetic code: successive triplet bases (three bases = one code word)
  • Triplet bases control amino acid sequence in proteins

Protein Synthesis

  • Transcription: DNA code transferred to RNA in the nucleus
    • RNA diffuses from nucleus to cytoplasm
    • DNA stays in nucleus
    • Multiple RNA types exist (messenger, transfer, ribosomal) with varied functions
      • Ribosomes are formed in cytoplasm, not nucleus
  • Translation: Protein formation in ribosomes
    • Ribosomes read messenger RNA, producing protein chains
    • Single mRNA can be read by multiple ribosomes simultaneously
    • Rough endoplasmic reticulum (ER) involved in protein synthesis and transport

Gene Regulation

  • Genetic regulation controls protein synthesis from transcription to protein formation
  • Different cells express different genes despite shared genetic code (e.g., cardiac vs. epithelial cells)
  • Enzyme regulation: Control mechanisms to regulate enzyme activity
    • Activator or inhibitor substances (e.g., hormones) can increase/decrease enzyme activity
  • Two Principal Mechanisms:
    • Genetic regulation (activating/inhibiting genes)
    • Enzyme regulation (activating/inhibiting enzymes)

Cell Reproduction

  • Genes control cell growth and division (mitosis)
  • Cell life cycles vary (10-30 hours for some cells; lifetime for others; Bone marrow cells, smooth muscle cells, neurons)
  • Cell Replication (DNA): DNA replicates into two identical strands (semi-conservative method)
  • Proofreading & Mutation: Enzymes correct replication errors; mutations result from undetected errors

Cell Death and Cancer

  • Apoptosis: Programmed cell death; cells shrink, condense, and are then digested.
    • Contrast with necrosis (cell swelling and bursting)
  • Cancer: Caused by mutations (among other factors) in cellular genes that regulate growth & mitosis
    • Most mutated cells die
    • Cancer develops when mutated cells evade normal feedback controls, evade immune system, or develop angiogenic factors

Cancer Development Factors

  • Mutations in multiple genes required for cancer development
  • Environmental factors (e.g., radiation, chemical exposure) increase mutation chances.
  • Hereditary tendencies reduce the number of required mutations by inheriting pre-cancerous genes
  • Viruses (e.g., hepatitis B, C, HIV) can increase the risk of cancer
  • Invasive characteristics: Cancer cells tend to detach, move, and metastasize.
  • Competition for nutrients, disruption of organ function

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