Gastrointestinal Medications Mechanism of Action Quiz
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Questions and Answers

What is the mechanism of action of Vedolizumab?

  • Binds to TNFα and prevents binding to TNF receptors
  • Reduces cAMP and attenuates protein kinases stimulation on H+/K+ ATPase
  • Reversibly inhibits α4β7 interaction with MAdCAM-1 on endothelial cells (correct)
  • Irreversibly inhibits H+/K+ ATPase and antagonizes all stimulants of gastric secretion

    • What is the mechanism of action of Metronidazole?

  • Reversibly inhibits α4β7 interaction with MAdCAM-1 on endothelial cells
  • Reduces cAMP and attenuates protein kinases stimulation on H+/K+ ATPase
  • Binds to TNFα and prevents binding to TNF receptors
  • Induces formation of ROS, inhibits protein synthesis, and causes DNA damage (correct)

    • What is the mechanism of action of Sulfasalazine?

  • Binds to TNFα and prevents binding to TNF receptors
  • Broken down by intestinal bacteria into 5-ASA or mesalamine (correct)
  • Reversibly inhibits α4β7 interaction with MAdCAM-1 on endothelial cells
  • Reduces cAMP and attenuates protein kinases stimulation on H+/K+ ATPase

    • What is the mechanism of action of Infiximab?

    <p>Binds to TNFα and prevents binding to TNF receptors</p> Signup and view all the answers

    What is the mechanism of action of Loperamide?

    <p>Binds to μ-opioid receptor on gut wall and inhibits Ach &amp; PG release</p> Signup and view all the answers

    What is the mechanism of action of Vedolizumab?

    <p>Reversibly inhibits α4β7 interaction with MAdCAM-1 on endothelial cells</p> Signup and view all the answers

    What is the mechanism of action of Infiximab?

    <p>Binds to TNFα and prevents binding to TNF receptors</p> Signup and view all the answers

    What is the mechanism of action of Metronidazole?

    <p>Prodrug that undergoes reduction to form highly active metabolite nitro-radical anion</p> Signup and view all the answers

    What is the mechanism of action of Sulfasalazine?

    <p>Prodrug that undergoes reduction to form highly active metabolite nitro-radical anion</p> Signup and view all the answers

    What is the mechanism of action of Loperamide?

    <p>μ-opioid receptor agonist that binds to μ-opioid receptor on gut wall and inhibits Ach &amp; PG rel.</p> Signup and view all the answers

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