Gastrointestinal Disorders: Peptic Ulcer Disease Introduction

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What is the main reason that the addition of aspirin to a selective COX-2 inhibitor reduces its ulcer-sparing benefit and increases ulcer risk?

Aspirin and COX-2 inhibitors compete for the same metabolic pathways, leading to increased toxicity.

Aspirin increases the absorption of the COX-2 inhibitor, leading to higher concentrations and more ulceration.

Aspirin and COX-2 inhibitors have synergistic effects on gastric acid production, leading to more ulceration.

Aspirin inhibits the production of prostaglandins, which are essential for maintaining gastric mucosal integrity. (correct)

According to the passage, which of the following statements about the use of corticosteroids and NSAIDs is correct?

The use of corticosteroids alone increases the risk of ulcers and complications.

The use of corticosteroids alone does not increase the risk of ulcers or complications.

The use of corticosteroids and NSAIDs concurrently has no effect on the risk of ulcers.

The use of corticosteroids and NSAIDs concurrently doubles the risk of ulcers. (correct)

Which of the following factors has been shown to cause peptic ulcer disease (PUD)?

Consumption of coffee, tea, or beer

Cigarette smoking (correct)

Psychological stress

Consumption of carbonated beverages

Which of the following is a common symptom of peptic ulcer disease?

Abdominal pain that is relieved by antacids Signup and view all the answers

According to the passage, which of the following is a recommended test to verify the eradication of H. pylori infection?

Urea breath test (UBT) and fecal antigen test Signup and view all the answers

Which of the following is NOT a common etiology of peptic ulcer disease?

Excessive alcohol consumption Signup and view all the answers

Which part of the duodenum is most commonly affected by duodenal ulcers?

First part of the duodenum (duodenal bulb) Signup and view all the answers

Which of the following is NOT involved in the pathophysiology of peptic ulcer disease?

Increased bicarbonate secretion Signup and view all the answers

Which of the following statements about gastric ulcers and acid secretion is correct?

Patients with gastric ulcers usually have reduced acid secretion (hypochlorhydria) Signup and view all the answers

Which of the following statements about COX-2 selective inhibitors is correct?

They have a lower risk of ulcers and GI complications than nonselective NSAIDs Signup and view all the answers

Gastrointestinal Disorders: Peptic Ulcer Disease Introduction

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Questions and Answers

What is the main reason that the addition of aspirin to a selective COX-2 inhibitor reduces its ulcer-sparing benefit and increases ulcer risk?

According to the passage, which of the following statements about the use of corticosteroids and NSAIDs is correct?

Which of the following factors has been shown to cause peptic ulcer disease (PUD)?

Which of the following is a common symptom of peptic ulcer disease?

According to the passage, which of the following is a recommended test to verify the eradication of H. pylori infection?

Which of the following is NOT a common etiology of peptic ulcer disease?

Which part of the duodenum is most commonly affected by duodenal ulcers?

Which of the following is NOT involved in the pathophysiology of peptic ulcer disease?

Which of the following statements about gastric ulcers and acid secretion is correct?

Which of the following statements about COX-2 selective inhibitors is correct?

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