Gastrointestinal Disorders: Peptic Ulcer Disease Introduction
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Questions and Answers

What is the main reason that the addition of aspirin to a selective COX-2 inhibitor reduces its ulcer-sparing benefit and increases ulcer risk?

  • Aspirin and COX-2 inhibitors compete for the same metabolic pathways, leading to increased toxicity.
  • Aspirin increases the absorption of the COX-2 inhibitor, leading to higher concentrations and more ulceration.
  • Aspirin and COX-2 inhibitors have synergistic effects on gastric acid production, leading to more ulceration.
  • Aspirin inhibits the production of prostaglandins, which are essential for maintaining gastric mucosal integrity. (correct)
  • According to the passage, which of the following statements about the use of corticosteroids and NSAIDs is correct?

  • The use of corticosteroids alone increases the risk of ulcers and complications.
  • The use of corticosteroids alone does not increase the risk of ulcers or complications.
  • The use of corticosteroids and NSAIDs concurrently has no effect on the risk of ulcers.
  • The use of corticosteroids and NSAIDs concurrently doubles the risk of ulcers. (correct)
  • Which of the following factors has been shown to cause peptic ulcer disease (PUD)?

  • Consumption of coffee, tea, or beer
  • Cigarette smoking (correct)
  • Psychological stress
  • Consumption of carbonated beverages
  • Which of the following is a common symptom of peptic ulcer disease?

    <p>Abdominal pain that is relieved by antacids</p> Signup and view all the answers

    According to the passage, which of the following is a recommended test to verify the eradication of H. pylori infection?

    <p>Urea breath test (UBT) and fecal antigen test</p> Signup and view all the answers

    Which of the following is NOT a common etiology of peptic ulcer disease?

    <p>Excessive alcohol consumption</p> Signup and view all the answers

    Which part of the duodenum is most commonly affected by duodenal ulcers?

    <p>First part of the duodenum (duodenal bulb)</p> Signup and view all the answers

    Which of the following is NOT involved in the pathophysiology of peptic ulcer disease?

    <p>Increased bicarbonate secretion</p> Signup and view all the answers

    Which of the following statements about gastric ulcers and acid secretion is correct?

    <p>Patients with gastric ulcers usually have reduced acid secretion (hypochlorhydria)</p> Signup and view all the answers

    Which of the following statements about COX-2 selective inhibitors is correct?

    <p>They have a lower risk of ulcers and GI complications than nonselective NSAIDs</p> Signup and view all the answers

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