Gastrin, HCl, and Mucous in Stomach Physiology

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Questions and Answers

Which factor is responsible for protecting the mucosa by secreting mucus and bicarbonate ion?

  • Gastrin
  • Parietal cells
  • Histamine
  • Prostaglandin (correct)

What is a common environmental factor that plays a role in the formation of peptic ulcers?

  • Alcohol consumption
  • Antioxidant intake
  • NSAIDs (correct)
  • Regular exercise

What is the mechanism of action of Histamine H2 receptor antagonists in treating peptic ulcers?

  • Reducing gastric acid secretion (correct)
  • Increasing acid production
  • Promoting mucosal blood flow
  • Decreasing prostaglandin levels

Which of the following is NOT a line of treatment for peptic ulcers?

<p>Bronchodilators (D)</p> Signup and view all the answers

Which component is directly responsible for neutralizing acidity in the stomach for peptic ulcer treatment?

<p>Antacids (D)</p> Signup and view all the answers

Which infection requires antibiotic treatment for eradication in patients with peptic ulcers?

<p>Helicobacter pylori (D)</p> Signup and view all the answers

Which of the following statements about proton pump inhibitors (PPIs) is correct?

<p>PPIs form covalent bonds with the H⁺/K⁺ ATPase enzyme in the parietal cell canaliculi. (B)</p> Signup and view all the answers

Which of the following is the primary function of H⁺/K⁺ ATPase in the parietal cells?

<p>Acidifying the stomach contents. (B)</p> Signup and view all the answers

What is the primary cause of peptic ulcers?

<p>Helicobacter pylori infection. (C)</p> Signup and view all the answers

Which of the following is the recommended first-line treatment for Helicobacter pylori eradication?

<p>Clarithromycin-based triple therapy. (A)</p> Signup and view all the answers

Which of the following statements about the pharmacokinetics of proton pump inhibitors (PPIs) is correct?

<p>PPIs are well-tolerated and have few side effects. (D)</p> Signup and view all the answers

Which of the following statements about the mechanism of action of proton pump inhibitors (PPIs) is incorrect?

<p>PPIs inhibit the exchange of H⁺ and K⁺ ions across the basolateral membrane of parietal cells. (C)</p> Signup and view all the answers

Which of the following is the primary cause of peptic ulcers?

<p>Infection with Helicobacter pylori bacteria (D)</p> Signup and view all the answers

Which of the following is NOT a function of parietal cells in the stomach?

<p>Secretion of bicarbonate ions (HCO3-) (C)</p> Signup and view all the answers

Which of the following drugs is classified as an H2-receptor antagonist used for the treatment of peptic ulcers?

<p>Ranitidine (B)</p> Signup and view all the answers

In the eradication of Helicobacter pylori infection, which of the following drug combinations is commonly used?

<p>Proton pump inhibitor + Clarithromycin + Amoxicillin (A)</p> Signup and view all the answers

Which of the following statements about the mechanism of gastric acid secretion is correct?

<p>Gastrin increases in response to a reduction in hydrochloric acid (HCl) levels (B)</p> Signup and view all the answers

What is the mechanism of action of H2-receptor antagonists in the treatment of peptic ulcers?

<p>Inhibition of gastric acid secretion by blocking histamine H2 receptors (B)</p> Signup and view all the answers

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