18 Questions
Which factor is responsible for protecting the mucosa by secreting mucus and bicarbonate ion?
Prostaglandin
What is a common environmental factor that plays a role in the formation of peptic ulcers?
NSAIDs
What is the mechanism of action of Histamine H2 receptor antagonists in treating peptic ulcers?
Reducing gastric acid secretion
Which of the following is NOT a line of treatment for peptic ulcers?
Bronchodilators
Which component is directly responsible for neutralizing acidity in the stomach for peptic ulcer treatment?
Antacids
Which infection requires antibiotic treatment for eradication in patients with peptic ulcers?
Helicobacter pylori
Which of the following statements about proton pump inhibitors (PPIs) is correct?
PPIs form covalent bonds with the H⁺/K⁺ ATPase enzyme in the parietal cell canaliculi.
Which of the following is the primary function of H⁺/K⁺ ATPase in the parietal cells?
Acidifying the stomach contents.
What is the primary cause of peptic ulcers?
Helicobacter pylori infection.
Which of the following is the recommended first-line treatment for Helicobacter pylori eradication?
Clarithromycin-based triple therapy.
Which of the following statements about the pharmacokinetics of proton pump inhibitors (PPIs) is correct?
PPIs are well-tolerated and have few side effects.
Which of the following statements about the mechanism of action of proton pump inhibitors (PPIs) is incorrect?
PPIs inhibit the exchange of H⁺ and K⁺ ions across the basolateral membrane of parietal cells.
Which of the following is the primary cause of peptic ulcers?
Infection with Helicobacter pylori bacteria
Which of the following is NOT a function of parietal cells in the stomach?
Secretion of bicarbonate ions (HCO3-)
Which of the following drugs is classified as an H2-receptor antagonist used for the treatment of peptic ulcers?
Ranitidine
In the eradication of Helicobacter pylori infection, which of the following drug combinations is commonly used?
Proton pump inhibitor + Clarithromycin + Amoxicillin
Which of the following statements about the mechanism of gastric acid secretion is correct?
Gastrin increases in response to a reduction in hydrochloric acid (HCl) levels
What is the mechanism of action of H2-receptor antagonists in the treatment of peptic ulcers?
Inhibition of gastric acid secretion by blocking histamine H2 receptors
Learn about how gastrin levels increase in response to HCl reduction, leading to gastrinoma. Understand the role of Cl- secretion by parietal cells and the importance of mucous in protecting the stomach mucosa from H+ diffusion. Discover how disturbance in the mucous layer can cause H+ to re-diffuse back to parietal cells.
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