Gastric Carcinoma Histologic Subtypes and Risk Factors

Choose a study mode

Play Quiz
Study Flashcards
Spaced Repetition
Chat to Lesson

Podcast

Play an AI-generated podcast conversation about this lesson

Questions and Answers

What is the main cause of diverticulosis?

  • Low fiber diet (correct)
  • Excessive fiber intake
  • Genetic predisposition
  • Old age

Which part of the colon is most commonly affected by diverticulosis?

  • Ascending colon
  • Transverse colon
  • Sigmoid colon (correct)
  • Rectum

What are the common clinical features of diverticulosis?

  • Constant diarrhea
  • Intermittent cramping (correct)
  • Upper abdominal pain
  • Right lower quadrant pain

Which demographic group is diverticulosis most common in?

<p>People in Western countries (A)</p> Signup and view all the answers

What complications can arise from obstructed diverticula?

<p>Peritonitis (D)</p> Signup and view all the answers

Why is diverticulosis less common in Japan and developing countries?

<p>High fiber diet (C)</p> Signup and view all the answers

Which histologic subtype of malignant epithelial neoplasm is characterized by loss of E-cadherin expression?

<p>Diffuse-type (B)</p> Signup and view all the answers

Which subtype of malignant epithelial neoplasm tends to predominate in high-risk areas like Japan and East Europe?

<p>Intestinal-type (B)</p> Signup and view all the answers

Which subtype of malignant epithelial neoplasm has a relatively uniform incidence across countries and no clearly identified precursor lesions?

<p>Diffuse-type (B)</p> Signup and view all the answers

What is a risk factor commonly associated with diffuse-type malignant epithelial neoplasms?

<p>Multifocal mucosal atrophy (C)</p> Signup and view all the answers

Which gene mutation is strongly associated with familial diffuse-type gastric cancer?

<p>CDH1 (D)</p> Signup and view all the answers

What is a common mechanism leading to decreased E-cadherin expression in sporadic diffuse-type gastric tumors?

<p>Hypermethylation and silencing of the CDH1 promoter (A)</p> Signup and view all the answers

Individuals with BRCA2 mutations are at increased risk of developing which type of gastric cancer?

<p>Diffuse gastric cancer (D)</p> Signup and view all the answers

What mutations are strongly associated with increased signaling via the Wnt pathway in gastric cancer?

<p>Loss-of-function mutations in APC and gain-of-function mutations in b-catenin (A)</p> Signup and view all the answers

Chronic inflammation promotes gastric neoplasia by genetic variants of genes encoding all EXCEPT:

<p>EGFR (D)</p> Signup and view all the answers

Which gene mutations are found in the majority of sporadic gastric cancers of both diffuse and intestinal types?

<p>TP53 mutations (C)</p> Signup and view all the answers

Which environmental factor affects the risk of gastric cancer due to H.pylori infection?

<p>Exposure to preserved foods (C)</p> Signup and view all the answers

What genetic variants are associated with an elevated risk of gastric cancer when accompanied by H.pylori infection?

<p>Genes encoding proinflammatory and immune response proteins (D)</p> Signup and view all the answers

Flashcards are hidden until you start studying

More Like This

Stomach Mucosa and Gastric Glands
44 questions
Disease of Stomach Quiz
22 questions
Gastric Physiology Flashcards
24 questions
Gastrointestinal Disorders Quiz
63 questions
Use Quizgecko on...
Browser
Browser