Gastric and Intestinal Histology Quiz
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Questions and Answers

Which cell type is responsible for the secretion of hydrochloric acid (HCl) in the gastric mucosa?

  • Parietal cells (correct)
  • Chief cells
  • Neck mucous cells
  • Enteroendocrine cells
  • Which histologic zone of the gastric mucosa contains stem cells?

  • Cardiac zone
  • Superficial zone
  • Deep zone
  • Neck zone (correct)
  • What is the primary role of chief cells in the gastric mucosa?

  • Secretion of pepsinogen (correct)
  • Secretion of intrinsic factor
  • Secretion of gastrin
  • Secretion of mucous
  • What condition can arise from the absence of intrinsic factor secreted by parietal cells?

    <p>Pernicious anemia (B)</p> Signup and view all the answers

    Which type of endocrine cells in the gastric mucosa are involved in the secretion of gastrin?

    <p>Open type enteroendocrine cells (D)</p> Signup and view all the answers

    Which layer of the small intestine contains the Auerbach’s myenteric plexus?

    <p>Muscular layer (C)</p> Signup and view all the answers

    What is the main function of Brunner’s glands found in the small intestine?

    <p>Secreting mucus and alkaline fluid (D)</p> Signup and view all the answers

    Which type of cells in the small intestine are responsible for producing antibacterial agents?

    <p>Paneth cells (C)</p> Signup and view all the answers

    Which component of the small intestine's histology consists of fingerlike projections?

    <p>Villi (A)</p> Signup and view all the answers

    What type of cells line the intestinal glands (Crypts of Lieberkühn)?

    <p>Enteroendocrine, goblet, and stem cells (D)</p> Signup and view all the answers

    Which type of epithelium is found in the anal canal?

    <p>Stratified squamous epithelium (A)</p> Signup and view all the answers

    What structure is responsible for the production of defensins in the small intestine?

    <p>Paneth cells (C)</p> Signup and view all the answers

    Which statement accurately describes the function of Bruner's glands?

    <p>They produce mucus. (B)</p> Signup and view all the answers

    What product is incorrectly matched to its corresponding cell type?

    <p>Neuroendocrine cell - Pepsinogen (A)</p> Signup and view all the answers

    What is the primary location of Peyer's patches?

    <p>Ileum (A)</p> Signup and view all the answers

    Which cell type is primarily involved in acid production?

    <p>Parietal cell (B)</p> Signup and view all the answers

    What is the role of the internal anal sphincter?

    <p>Controls defecation reflex (D)</p> Signup and view all the answers

    Which cell type is not found in the stomach?

    <p>Enterocyte (D)</p> Signup and view all the answers

    Which sphincter is located at the junction between the esophagus and stomach?

    <p>Esophagogastric sphincter (D)</p> Signup and view all the answers

    What primarily contributes to the conversion of food into chyme in the stomach?

    <p>Secretions of gastric mucosa (C)</p> Signup and view all the answers

    Which structure is considered part of the intrinsic innervation of the gut?

    <p>Myenteric (Auerbach’s) plexus (D)</p> Signup and view all the answers

    What is primarily secreted by gastric mucosa to aid in digestion?

    <p>Hydrochloric acid and proteolytic enzymes (A)</p> Signup and view all the answers

    Which cellular structure in the stomach epithelium helps protect against acidic conditions?

    <p>Mucous cells (C)</p> Signup and view all the answers

    What type of epithelium is found in the mucosa of the esophagus?

    <p>Stratified squamous nonkeratinized epithelium (B)</p> Signup and view all the answers

    Which layer of the esophagus contains the Auerbach’s plexus?

    <p>Muscularis externa (D)</p> Signup and view all the answers

    What is true about the muscularis layer of the esophagus?

    <p>It has both skeletal and smooth muscle in the middle third. (B)</p> Signup and view all the answers

    What anatomical structure marks the transition from the esophagus to the stomach?

    <p>Gastroesophageal junction (C)</p> Signup and view all the answers

    Which characteristic is not associated with the mucosal layer of the esophagus?

    <p>Absence of stratified epithelium (C)</p> Signup and view all the answers

    Which part of the lower digestive tract is responsible for the majority of nutrient absorption?

    <p>Small intestine (D)</p> Signup and view all the answers

    What type of muscle layers compose the tunica muscularis in the digestive tract?

    <p>Smooth muscle (A)</p> Signup and view all the answers

    What is the primary function of the lamina propria in the mucosa?

    <p>Support and transport nutrients (B)</p> Signup and view all the answers

    Which of the following structures is NOT a component of the tunica adventitia?

    <p>Mesothelium (B)</p> Signup and view all the answers

    How does the muscularis externa primarily function in the digestive tract?

    <p>To facilitate peristalsis (A)</p> Signup and view all the answers

    What structure is primarily responsible for innervation in the muscularis externa?

    <p>Auerbach’s myenteric plexus (A)</p> Signup and view all the answers

    Which layer of the digestive tract contains glands in the esophagus and duodenum but is typically devoid of them elsewhere?

    <p>Tunica submucosa (C)</p> Signup and view all the answers

    What is the role of lymphoid nodules found in the lamina propria?

    <p>Participate in immune response (C)</p> Signup and view all the answers

    Flashcards

    Lower Digestive Tract Components

    The lower digestive tract includes the stomach, small intestine (duodenum, jejunum, ileum), and large intestine (cecum, appendix, colon, rectum).

    Digestive Tract Layers

    The digestive tract has four main layers: mucosa, submucosa, muscularis externa, and serosa/adventitia.

    Tunica Mucosa

    Innermost layer of the digestive tract, consisting of epithelium, lamina propria (loose connective tissue), and muscularis mucosae(smooth muscle).

    Tunica Submucosa

    Layer beneath the mucosa, made of dense irregular connective tissue, containing blood vessels, lymph vessels, and Meissner's plexus (part of the enteric nervous system).

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    Tunica Muscularis

    Layer containing smooth muscles arranged in inner circular and outer longitudinal layers responsible for peristalsis. Excluding the esophagus, generally two layers.

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    Tunica Adventitia/Serosa

    Outermost layer of the digestive tract, either a thin connective tissue layer (adventitia) or a serous membrane layer (serosa) containing simple squamous epithelium when intraperitoneal. This membrane is crucial for protection, support and interaction with surrounding structures.

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    Muscularis Externa

    Smooth muscles in the outer layer of the alimentary canal (except in the esophagus).

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    Enteric Nervous System

    The nervous system of the digestive tract with intrinsic ganglia (Auerbach's / Meissner’s plexuses) that regulate smooth muscle movement and gastrointestinal secretions.

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    Esophagus Length

    The esophagus is approximately 25 centimeters long, a muscular tube connecting the pharynx to the stomach.

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    Esophagus Mucosa

    The innermost layer of the esophagus is lined with stratified squamous nonkeratinized epithelium, which allows for passage of food without abrasion. This lining folds longitudinally to accommodate distension.

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    Esophageal Glands

    These glands are present in both the lamina propria (mucosal glands) and submucosa (esophageal glands proper) of the esophagus, secreting mucus to lubricate food passage.

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    Esophageal Muscularis Externa

    The muscular layer of the esophagus is unique, containing both skeletal and smooth muscle fibers. The upper 1/3 is mainly skeletal muscle, ensuring voluntary swallowing, while the lower 1/3 is smooth muscle, controlled by the autonomic nervous system, for involuntary peristalsis.

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    Esophageal Sphincter

    The transition from the esophagus to the stomach is not a true anatomical sphincter, but a functional one. This is marked by the change in lining epithelium, from stratified squamous to columnar.

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    Esophagogastric sphincter

    A muscular valve at the junction of the esophagus and stomach, preventing food reflux back into the esophagus.

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    Pyloric sphincter

    A muscular valve at the junction of the stomach and small intestine, controlling the flow of chyme into the duodenum.

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    Ileocecal valve

    A valve at the junction of the ileum (small intestine) and the cecum (large intestine), preventing backflow from the large intestine into the small intestine.

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    Internal anal sphincter

    A ring of involuntary smooth muscle at the anus, controlling the release of waste.

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    What are structures seen in gastric epithelium?

    The gastric epithelium contains mucous cells responsible for mucus secretion, parietal cells that produce hydrochloric acid, chief cells that produce pepsinogen, and enteroendocrine cells that release various hormones.

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    Gastric Mucosa Zones

    The gastric mucosa is divided into three zones: superficial, neck, and deep. The superficial zone contains surface mucous cells and gland openings. The neck zone has stem cells and neck mucous cells. The deep zone contains glands with parietal and chief cells.

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    Parietal Cell

    Parietal cells are found in the deep zone of the gastric mucosa. They are responsible for producing hydrochloric acid (HCl) and intrinsic factor, essential for vitamin B12 absorption.

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    Chief Cell

    Chief cells reside in the deep zone of the gastric mucosa. They synthesize and release pepsinogen, a precursor to the digestive enzyme pepsin.

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    Enteroendocrine Cells

    Enteroendocrine cells are scattered within the gastric mucosa. They produce hormones that regulate digestion, such as gastrin, which stimulates acid production.

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    Open vs. Closed Enteroendocrine Cells

    Enteroendocrine cells can be open or closed. Open cells release hormones directly into the lumen, while closed cells release hormones into the blood.

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    What makes Brunner's glands special?

    Brunner's glands are branched tubuloalveolar glands found in the duodenum that secrete mucus and an alkaline fluid to neutralize acidic chyme from the stomach. They also secrete the hormone urogastron.

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    What are the 'fingers' of the small intestine?

    Villi are finger-like projections of the mucosa in the small intestine that increase surface area for absorption of nutrients. These projections contain lacteals, lymphatic vessels for fat absorption.

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    What do Paneth cells produce?

    Paneth cells are found in the crypts of Lieberkühn of the small intestine and produce antibacterial agents like lysozyme, defensin, and TNF-alpha.

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    What do goblet cells secrete?

    Goblet cells are unicellular glands found in the epithelial layer of the small intestine that produce musinogen. Musinogen, when hydrated, becomes mucin, a component of mucus.

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    What is the function of the myenteric plexus?

    The myenteric plexus, also known as Auerbach's plexus, is a nerve network located between the inner circular and outer longitudinal layers of the muscularis externa in the small intestine. It regulates peristaltic movements.

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    What is the rectum?

    The rectum is the final segment of the digestive tract, connecting the colon to the anal canal. It stores feces before elimination.

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    What are the anal sphincters?

    The anal canal has two sphincters: the internal anal sphincter (involuntary, smooth muscle) and the external anal sphincter (voluntary, skeletal muscle). These control the passage of feces.

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    What are the main cell types found in the lining of the anus?

    The anal canal transitions from simple columnar epithelium in the rectum to stratified squamous epithelium towards the anus. This reflects the change in function, from absorption to protection against abrasion.

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    What is the function of the internal anal sphincter?

    The internal anal sphincter is a ring of smooth muscle that involuntarily constricts to prevent the leakage of feces. It is always partially contracted.

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    What is the function of the external anal sphincter?

    The external anal sphincter is a ring of skeletal muscle that allows for voluntary control over defecation. It can relax to allow feces to pass or contract to prevent it.

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    What is the junctional zone in the anal canal?

    The junctional zone marks the transition between the simple columnar epithelium of the rectum and the stratified squamous epithelium of the anal canal. A line called the pectinate line defines this junction.

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    What are the major features of the anal columns?

    The anal columns are longitudinal folds in the lining of the anal canal. They contain blood vessels, which can become enlarged, leading to hemorrhoids.

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    What is the submucosa of the anal canal?

    The submucosa of the anal canal is a layer of dense connective tissue that contains the internal anal sphincter. It also holds blood vessels and nerves.

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    Study Notes

    Lower Digestive Tract

    • Comprises the stomach, small intestine (duodenum, jejunum, ileum), and large intestine (cecum, appendix, colon, rectum).

    • Processes include digestion of food, absorption of digested products, and absorption and reabsorption of secreted fluids.

    Layers of the Digestive Tract (DT)

    • Tunica Mucosa: Epithelium (innermost), lamina propria (connective tissue), and muscularis mucosae (smooth muscle).

    • Tunica Submucosa: Contains connective tissue, blood vessels, and Meissner's plexus (part of the enteric nervous system).

    • Tunica Muscularis: Two layers of smooth muscle (mostly, with a third layer in the stomach): inner circular and outer longitudinal.

      • Includes Auerbach's plexus (part of the enteric nervous system)
    • Tunica Adventitia (Serosa): Connective tissue layer, sometimes covered in epithelium (serosa).

    Esophagus

    • Mucosa: stratified squamous non-keratinized epithelium.
    • Mucosa has longitudinal folds that disappear when the lumen is distended (obstructed).
    • Submucosa: dense, fibroelastic CT; esophageal glands.
    • Muscularis externa: upper 1/3 skeletal muscle, middle 1/3 both skeletal and smooth, lower 1/3 smooth muscle.
    • Adventitia (until diaphragm, then serosa).

    Stomach

    • Regions: cardia, fundus, body, pylorus.

    • Gastric glands have several cell types: mucous cells (surface and neck), parietal cells (acid production), chief cells (pepsinogen), enteroendocrine cells (various hormones), and stem cells.

    • Mucosa:

    • Mocosal folds called rugae.

    • Three Layers of Muscle: Oblique, circular, and longitudinal layers.

    • Three zones of mucosa: superficial, neck, and deep zones.

    Small Intestine

    • Composed of duodenum, jejunum, and ileum.
    • Characteristics: villi, plicae circulares, intestinal glands (crypts of Lieberkühn), Brunner's glands (in duodenum), Peyer's patches (in ileum), and lacteals.
    • Cell types: enterocytes (absorptive), goblet cells (mucus), Paneth cells (antibacterial agents), enteroendocrine cells (various hormones), and stem cells.
    • Layers: mucosa, submucosa, muscularis externa (circular & longitudinal smooth muscle layers), serosa (except duodenum's adventitia).

    Large Intestine

    • Parts: cecum, ascending colon, transverse colon, descending colon, sigmoid colon, rectum, and anal canal.
    • Absence of villi and Brunner's glands.
    • Constant muscular tonus maintained by taeniae coli.
    • Presence of haustra coli (sacculations)
    • Presence of numerous fat-filled pouches called appendices epiploicae.
    • Epithelial layer: primarily columnar cells and numerous goblet cells
    • Muscularis externa: usually similar composition as in the small intestine

    Appendix

    • Part of the large intestine.
    • Structure: crypts are abundant; lymphoid tissue present

    Anal Canal

    • Last portion of the digestive tract.
    • Epithelium transitions from simple columnar epithelium to stratified squamous epithelium.
    • Contains internal and external anal sphincters.

    Sphincters

    • Specialized thickenings of muscle in the bowel wall that act as valves.
    • Located between esophagus and stomach (esophagogastric sphincter), stomach and duodenum (pyloric sphincter), ileum and cecum (ileocecal valve), and rectum and anus (internal and external anal sphincters).

    Innervation

    • Enteric nervous system: Submucosal plexus (Meissner's) and Myenteric plexus (Auerbach's).
    • Extrinsic innervation: sympathetic and parasympathetic.

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    Description

    Test your knowledge of gastric and intestinal histology with this focused quiz. From the roles of various cell types to the structure of mucosal layers, challenge yourself on key concepts in digestive system anatomy. Perfect for students in anatomy or histology courses!

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