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Questions and Answers
Which of the following represents the correct relationship between partial pressures of oxygen in the alveoli and blood during gas exchange?
Which of the following represents the correct relationship between partial pressures of oxygen in the alveoli and blood during gas exchange?
- $P_{O_2}$ alveolar air = $P_{O_2}$ blood
- $P_{O_2}$ alveolar air > $P_{O_2}$ blood (correct)
- $P_{O_2}$ alveolar air < $P_{O_2}$ blood
- The relationship varies based on metabolic demand
Which of the following conditions would directly lead to a decrease in alveolar ventilation?
Which of the following conditions would directly lead to a decrease in alveolar ventilation?
- CNS depression affecting the brainstem (correct)
- Decreased airway resistance
- Increased $P_{O_2}$ in inspired air
- Increased lung compliance
In a scenario where a person ascends to a high altitude, what is the primary mechanism by which their body compensates to maintain adequate oxygen uptake?
In a scenario where a person ascends to a high altitude, what is the primary mechanism by which their body compensates to maintain adequate oxygen uptake?
- Increasing alveolar ventilation despite the lower $P_{O_2}$ of inspired air. (correct)
- Increasing the concentration of oxygen in inspired air.
- Decreasing the diffusion distance in the alveoli
- Decreasing alveolar ventilation to reduce oxygen demand.
What is the most significant factor that determines the binding of oxygen to hemoglobin, according to the law of mass action?
What is the most significant factor that determines the binding of oxygen to hemoglobin, according to the law of mass action?
Based on Fick's law of diffusion, which of these scenarios would result in a decreased rate of gas exchange in the lungs?
Based on Fick's law of diffusion, which of these scenarios would result in a decreased rate of gas exchange in the lungs?
Someone with fibrotic lung disease has thickened alveolar membranes. How does this affect gas exchange in the lungs and what is the primary compensatory mechanism the body employs?
Someone with fibrotic lung disease has thickened alveolar membranes. How does this affect gas exchange in the lungs and what is the primary compensatory mechanism the body employs?
If a patient has central chemoreceptors that are NOT functioning properly, how will this affect their respiratory response to increased arterial $P_{CO_2}$?
If a patient has central chemoreceptors that are NOT functioning properly, how will this affect their respiratory response to increased arterial $P_{CO_2}$?
In the context of gas transport in the blood, what is the significance of carbonic anhydrase?
In the context of gas transport in the blood, what is the significance of carbonic anhydrase?
Which aspect of the ventral respiratory group (VRG) makes it essential for generating basic breathing rhythms?
Which aspect of the ventral respiratory group (VRG) makes it essential for generating basic breathing rhythms?
What would be the physiological consequence of a drug overdose that inhibits the activity of the dorsal respiratory group (DRG)?
What would be the physiological consequence of a drug overdose that inhibits the activity of the dorsal respiratory group (DRG)?
In what form is the majority of carbon dioxide transported in the blood?
In what form is the majority of carbon dioxide transported in the blood?
What is the effect of increased levels of carbon dioxide in the blood on ventilation rate, and through which mechanism is this primarily mediated?
What is the effect of increased levels of carbon dioxide in the blood on ventilation rate, and through which mechanism is this primarily mediated?
What is the role of the pontine respiratory group (PRG) in respiration?
What is the role of the pontine respiratory group (PRG) in respiration?
What effect does an increase in blood pH (more alkaline) typically have on ventilation, and how is this mediated?
What effect does an increase in blood pH (more alkaline) typically have on ventilation, and how is this mediated?
Which factor does not directly affect the diffusion of gases in the alveoli?
Which factor does not directly affect the diffusion of gases in the alveoli?
What is the primary role of hemoglobin in oxygen transport?
What is the primary role of hemoglobin in oxygen transport?
What triggers an increase in ventilation when oxygen levels fall below 60 mm Hg?
What triggers an increase in ventilation when oxygen levels fall below 60 mm Hg?
Emphysema is characterized by the destruction of alveoli, leading to a reduced surface area for gas exchange. How does this condition primarily affect blood gas levels?
Emphysema is characterized by the destruction of alveoli, leading to a reduced surface area for gas exchange. How does this condition primarily affect blood gas levels?
Following the chloride shift, how is the electrical neutrality of the cell maintained during carbon dioxide transport in red blood cells?
Following the chloride shift, how is the electrical neutrality of the cell maintained during carbon dioxide transport in red blood cells?
In a healthy individual at rest, what is the expected partial pressure of oxygen ($P_{O_2}$) in the alveoli?
In a healthy individual at rest, what is the expected partial pressure of oxygen ($P_{O_2}$) in the alveoli?
How would an increase in the thickness of the alveolar membrane impact gas exchange, and what compensatory mechanism might the body employ?
How would an increase in the thickness of the alveolar membrane impact gas exchange, and what compensatory mechanism might the body employ?
What is the expected relationship between the partial pressure of carbon dioxide ($P_{CO_2}$) in the blood and the alveoli?
What is the expected relationship between the partial pressure of carbon dioxide ($P_{CO_2}$) in the blood and the alveoli?
If a person's arterial $P_{O_2}$ is measured to be unusually low despite a normal alveolar $P_{O_2}$, what is the likely cause?
If a person's arterial $P_{O_2}$ is measured to be unusually low despite a normal alveolar $P_{O_2}$, what is the likely cause?
How does an increase in altitude affect the partial pressure of oxygen in the inspired air, and what is the initial physiological response?
How does an increase in altitude affect the partial pressure of oxygen in the inspired air, and what is the initial physiological response?
How does the body primarily compensate for the effects of increased airway resistance on alveolar ventilation?
How does the body primarily compensate for the effects of increased airway resistance on alveolar ventilation?
What is the primary role of hemoglobin in oxygen transport within the blood?
What is the primary role of hemoglobin in oxygen transport within the blood?
What is the effect of increased carbon dioxide levels in the blood on the affinity of hemoglobin for oxygen, and what is this effect known as?
What is the effect of increased carbon dioxide levels in the blood on the affinity of hemoglobin for oxygen, and what is this effect known as?
How is the majority of carbon dioxide transported from the tissues to the lungs?
How is the majority of carbon dioxide transported from the tissues to the lungs?
What is the significance of the 'chloride shift' in the context of carbon dioxide transport?
What is the significance of the 'chloride shift' in the context of carbon dioxide transport?
How do peripheral chemoreceptors respond to a decrease in arterial $P_{O_2}$?
How do peripheral chemoreceptors respond to a decrease in arterial $P_{O_2}$?
What is the primary function of the Pre-Bötzinger complex within the ventral respiratory group (VRG)?
What is the primary function of the Pre-Bötzinger complex within the ventral respiratory group (VRG)?
How do increased levels of hydrogen ions ($H^+$) in the cerebrospinal fluid (CSF) affect central chemoreceptors?
How do increased levels of hydrogen ions ($H^+$) in the cerebrospinal fluid (CSF) affect central chemoreceptors?
What is the overall effect of the pontine respiratory group (PRG) on respiration?
What is the overall effect of the pontine respiratory group (PRG) on respiration?
Which is the primary way central chemoreceptors respond to changes in arterial $P_{CO_2}$?
Which is the primary way central chemoreceptors respond to changes in arterial $P_{CO_2}$?
What is the primary effect of carbon monoxide (CO) on oxygen transport in the blood?
What is the primary effect of carbon monoxide (CO) on oxygen transport in the blood?
In the context of gas exchange dynamics, how does the rate of blood flow through pulmonary capillaries affect gas exchange efficiency?
In the context of gas exchange dynamics, how does the rate of blood flow through pulmonary capillaries affect gas exchange efficiency?
How do the intercostal nerves contribute to the process of breathing?
How do the intercostal nerves contribute to the process of breathing?
How does severe anemia (reduced hemoglobin concentration) primarily affect the oxygen content of arterial blood?
How does severe anemia (reduced hemoglobin concentration) primarily affect the oxygen content of arterial blood?
What effect would a drug that selectively stimulates the dorsal respiratory group (DRG) have on respiration?
What effect would a drug that selectively stimulates the dorsal respiratory group (DRG) have on respiration?
Flashcards
What is Hypoxia?
What is Hypoxia?
Too little oxygen in the body.
What is Hypercapnia?
What is Hypercapnia?
Increased concentrations of carbon dioxide in the body.
What is Partial Pressure?
What is Partial Pressure?
The pressure exerted by an individual gas in a mixture of gases.
What is Total Pressure of Mixed Gas?
What is Total Pressure of Mixed Gas?
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What the the relationship of POâ‚‚ in alveolar air and blood?
What the the relationship of POâ‚‚ in alveolar air and blood?
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What is the relationship of PCOâ‚‚ in blood and alveolar air during gas exchange?
What is the relationship of PCOâ‚‚ in blood and alveolar air during gas exchange?
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What is the relationship between POâ‚‚ in the blood and in tissues?
What is the relationship between POâ‚‚ in the blood and in tissues?
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What is the relationship between PCOâ‚‚ in tissues and in the blood?
What is the relationship between PCOâ‚‚ in tissues and in the blood?
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What is low alveolar POâ‚‚ in Inspired Air?
What is low alveolar POâ‚‚ in Inspired Air?
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What is Alveolar Ventilation?
What is Alveolar Ventilation?
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What is HbO2 (oxyhemoglobin)?
What is HbO2 (oxyhemoglobin)?
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What does an increase in PO2 do
What does an increase in PO2 do
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What is a bicarbonate ion?
What is a bicarbonate ion?
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What is the Dorsal respiratory group:
What is the Dorsal respiratory group:
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What are Peripheral chemoreceptors?
What are Peripheral chemoreceptors?
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What are Central chemoreceptors?
What are Central chemoreceptors?
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What is low alveolar PO2 in Alveolar ventilation?
What is low alveolar PO2 in Alveolar ventilation?
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What is Ventral respiratory group (VRG)?
What is Ventral respiratory group (VRG)?
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What is Breathing?
What is Breathing?
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What is alveolar hypoventilation?
What is alveolar hypoventilation?
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What can cause alveolar hypoventilation?
What can cause alveolar hypoventilation?
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What must happen to gas, before binding to hemoglobin?
What must happen to gas, before binding to hemoglobin?
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What is the effect of low alveolar POâ‚‚?
What is the effect of low alveolar POâ‚‚?
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What does a decrease in PO2 do?
What does a decrease in PO2 do?
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What are pontine respiratory groups?
What are pontine respiratory groups?
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Control of Breathing?
Control of Breathing?
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What conditions trigger increased ventilation via peripheral chemoreceptors?
What conditions trigger increased ventilation via peripheral chemoreceptors?
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What do central chemoreceptors do?
What do central chemoreceptors do?
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Study Notes
- Gas exchange and transport involves the exchange of oxygen and carbon dioxide in the body Ch 18
- Chapter covers gas exchange in the lungs and tissues, gas transport in the blood, and regulation of ventilation
Introduction to Gas Exchange
- The body requires oxygen and eliminates carbon dioxide
- Hypoxia refers to insufficient oxygen levels in the body
- Hypercapnia refers to elevated carbon dioxide levels in the body
- To prevent hypoxia and hypercapnia, the body manages three regulated variables: oxygen, carbon dioxide, and pH
Gas Exchange in the Lungs and Tissues
- Breathing facilitates the bulk movement of air into and out of the lungs.
- Individual gases travel along partial pressure gradients until equilibrium, which allows for gas exchange
- The total pressure of a gas mixture equals the sum of the pressures of each individual gas
- Gas exchange occurs between alveoli and blood
- The partial pressure of oxygen in the alveolar air is greater than in the blood
- The partial pressure of carbon dioxide in the blood is greater than in the alveolar air
- Gas exchange occurs between blood and tissues
- The partial pressure of oxygen in the blood is greater than in the tissue
- The partial pressure of carbon dioxide in the tissue is greater than in the blood
Lower Alveolar Oxygen
- The level of oxygen affects oxygen uptake
- Low alveolar oxygen results from abnormally low oxygen in the inspired air
- Higher altitudes reduce oxygen partial pressure
- Low alveolar oxygen stems from inadequate alveolar ventilation (hypoventilation)
- Decreased lung compliance, is a factor, such as with asbestosis
- Increased airway resistance can lowers oxygen levels, such as with COPD
- Central nervous system (CNS) depression, from alcohol poisoning or drug overdose, may lower oxygen levels
Factors Affecting Gas Exchange in the Alveoli
- Oxygen and carbon dioxide diffuse across a diffusion barrier between lung and blood
- The barrier includes surfactant, alveolar epithelium, fused basement membranes, and the nucleus of endothelial cell, plasma, and red blood cells
Pathologies that Cause Hypoxia
- Normal lung function facilitates efficient diffusion based on surface area, barrier permeability, and distance
- Emphysema involves the destruction of alveoli, reducing the surface area for gas exchange
- Fibrotic Lung Disease is typified by thickened alveolar membranes, slowing gas exchange and decreasing lung compliance
- Pulmonary Edema occurs when fluid in the interstitial space increases the diffusion distance
- Asthma is defined as increased airway resistance that diminishes alveolar ventilation
Gas Transport in the Blood
- Gas enters the capillaries and first dissolves in the plasma
- Dissolved gas accounts for less than 2% of oxygen in blood
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