Gas Exchange and Transport Ch 18 Physio Lecture

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Questions and Answers

Which of the following represents the correct relationship between partial pressures of oxygen in the alveoli and blood during gas exchange?

  • $P_{O_2}$ alveolar air = $P_{O_2}$ blood
  • $P_{O_2}$ alveolar air > $P_{O_2}$ blood (correct)
  • $P_{O_2}$ alveolar air < $P_{O_2}$ blood
  • The relationship varies based on metabolic demand

Which of the following conditions would directly lead to a decrease in alveolar ventilation?

  • CNS depression affecting the brainstem (correct)
  • Decreased airway resistance
  • Increased $P_{O_2}$ in inspired air
  • Increased lung compliance

In a scenario where a person ascends to a high altitude, what is the primary mechanism by which their body compensates to maintain adequate oxygen uptake?

  • Increasing alveolar ventilation despite the lower $P_{O_2}$ of inspired air. (correct)
  • Increasing the concentration of oxygen in inspired air.
  • Decreasing the diffusion distance in the alveoli
  • Decreasing alveolar ventilation to reduce oxygen demand.

What is the most significant factor that determines the binding of oxygen to hemoglobin, according to the law of mass action?

<p>The partial pressure of oxygen ($P_{O_2}$). (B)</p> Signup and view all the answers

Based on Fick's law of diffusion, which of these scenarios would result in a decreased rate of gas exchange in the lungs?

<p>An increase in the diffusion distance due to pulmonary edema. (C)</p> Signup and view all the answers

Someone with fibrotic lung disease has thickened alveolar membranes. How does this affect gas exchange in the lungs and what is the primary compensatory mechanism the body employs?

<p>Decreased gas exchange; increased ventilation rate (D)</p> Signup and view all the answers

If a patient has central chemoreceptors that are NOT functioning properly, how will this affect their respiratory response to increased arterial $P_{CO_2}$?

<p>Decreased ventilation because the primary central drive is impaired. (D)</p> Signup and view all the answers

In the context of gas transport in the blood, what is the significance of carbonic anhydrase?

<p>It catalyzes the conversion of carbon dioxide and water to bicarbonate and hydrogen ions. (A)</p> Signup and view all the answers

Which aspect of the ventral respiratory group (VRG) makes it essential for generating basic breathing rhythms?

<p>The Pre-Bötzinger complex within it, which exhibits pacemaker activity. (D)</p> Signup and view all the answers

What would be the physiological consequence of a drug overdose that inhibits the activity of the dorsal respiratory group (DRG)?

<p>Decreased rate and depth of breathing or apnea. (B)</p> Signup and view all the answers

In what form is the majority of carbon dioxide transported in the blood?

<p>As bicarbonate ions ($HCO_3^−$) (D)</p> Signup and view all the answers

What is the effect of increased levels of carbon dioxide in the blood on ventilation rate, and through which mechanism is this primarily mediated?

<p>Increased ventilation mediated by central chemoreceptors detecting changes in CSF pH. (A)</p> Signup and view all the answers

What is the role of the pontine respiratory group (PRG) in respiration?

<p>To ensure a smooth respiratory rhythm by influencing the medulla. (A)</p> Signup and view all the answers

What effect does an increase in blood pH (more alkaline) typically have on ventilation, and how is this mediated?

<p>Decreased ventilation via central chemoreceptors. (A)</p> Signup and view all the answers

Which factor does not directly affect the diffusion of gases in the alveoli?

<p>The blood type of the individual (A)</p> Signup and view all the answers

What is the primary role of hemoglobin in oxygen transport?

<p>Binding to oxygen to increase the amount of oxygen that can be carried in the blood. (D)</p> Signup and view all the answers

What triggers an increase in ventilation when oxygen levels fall below 60 mm Hg?

<p>Peripheral chemoreceptors in the carotid and aortic bodies. (B)</p> Signup and view all the answers

Emphysema is characterized by the destruction of alveoli, leading to a reduced surface area for gas exchange. How does this condition primarily affect blood gas levels?

<p>Decreases $P_{O_2}$ and increases $P_{CO_2}$ in arterial blood. (C)</p> Signup and view all the answers

Following the chloride shift, how is the electrical neutrality of the cell maintained during carbon dioxide transport in red blood cells?

<p>Chloride ions ($Cl^−$) are transported into the cell as bicarbonate ions ($HCO_3^−$) exit. (C)</p> Signup and view all the answers

In a healthy individual at rest, what is the expected partial pressure of oxygen ($P_{O_2}$) in the alveoli?

<p>Approximately 100 mm Hg (A)</p> Signup and view all the answers

How would an increase in the thickness of the alveolar membrane impact gas exchange, and what compensatory mechanism might the body employ?

<p>Decrease gas exchange; increased ventilation rate (A)</p> Signup and view all the answers

What is the expected relationship between the partial pressure of carbon dioxide ($P_{CO_2}$) in the blood and the alveoli?

<p>$P_{CO_2}$ in the blood is typically higher than in the alveoli. (C)</p> Signup and view all the answers

If a person's arterial $P_{O_2}$ is measured to be unusually low despite a normal alveolar $P_{O_2}$, what is the likely cause?

<p>A diffusion barrier between the alveoli and the blood (C)</p> Signup and view all the answers

How does an increase in altitude affect the partial pressure of oxygen in the inspired air, and what is the initial physiological response?

<p>Decreases $P_{O_2}$; increased ventilation rate (D)</p> Signup and view all the answers

How does the body primarily compensate for the effects of increased airway resistance on alveolar ventilation?

<p>Increasing the tidal volume through deeper breaths (C)</p> Signup and view all the answers

What is the primary role of hemoglobin in oxygen transport within the blood?

<p>To bind and carry the majority of oxygen in the blood (D)</p> Signup and view all the answers

What is the effect of increased carbon dioxide levels in the blood on the affinity of hemoglobin for oxygen, and what is this effect known as?

<p>Decreased affinity; Bohr effect (C)</p> Signup and view all the answers

How is the majority of carbon dioxide transported from the tissues to the lungs?

<p>As bicarbonate ions ($HCO_3^−$) in the plasma (D)</p> Signup and view all the answers

What is the significance of the 'chloride shift' in the context of carbon dioxide transport?

<p>It exchanges chloride ions for bicarbonate ions across the red blood cell membrane (B)</p> Signup and view all the answers

How do peripheral chemoreceptors respond to a decrease in arterial $P_{O_2}$?

<p>By increasing the ventilation rate (D)</p> Signup and view all the answers

What is the primary function of the Pre-Bötzinger complex within the ventral respiratory group (VRG)?

<p>Generating the basic rhythm of breathing (B)</p> Signup and view all the answers

How do increased levels of hydrogen ions ($H^+$) in the cerebrospinal fluid (CSF) affect central chemoreceptors?

<p>Stimulate them, leading to increased ventilation (D)</p> Signup and view all the answers

What is the overall effect of the pontine respiratory group (PRG) on respiration?

<p>It ensures a smooth respiratory rhythm (C)</p> Signup and view all the answers

Which is the primary way central chemoreceptors respond to changes in arterial $P_{CO_2}$?

<p>They respond to $H^+$ generated from $CO_2$ crossing the blood-brain barrier (B)</p> Signup and view all the answers

What is the primary effect of carbon monoxide (CO) on oxygen transport in the blood?

<p>CO binds more strongly to hemoglobin than oxygen, reducing oxygen carrying capacity (A)</p> Signup and view all the answers

In the context of gas exchange dynamics, how does the rate of blood flow through pulmonary capillaries affect gas exchange efficiency?

<p>Increased blood flow decreases gas exchange by reducing the time for diffusion (A)</p> Signup and view all the answers

How do the intercostal nerves contribute to the process of breathing?

<p>They innervate the intercostal muscles, aiding in expanding and contracting the rib cage (B)</p> Signup and view all the answers

How does severe anemia (reduced hemoglobin concentration) primarily affect the oxygen content of arterial blood?

<p>It reduces the oxygen-carrying capacity despite normal partial pressure of oxygen (B)</p> Signup and view all the answers

What effect would a drug that selectively stimulates the dorsal respiratory group (DRG) have on respiration?

<p>Increased rate and depth of inspiration (C)</p> Signup and view all the answers

Flashcards

What is Hypoxia?

Too little oxygen in the body.

What is Hypercapnia?

Increased concentrations of carbon dioxide in the body.

What is Partial Pressure?

The pressure exerted by an individual gas in a mixture of gases.

What is Total Pressure of Mixed Gas?

The sum of partial pressures of individual gases.

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What the the relationship of POâ‚‚ in alveolar air and blood?

Oxygen pressure in alveolar air is greater than oxygen pressure in blood.

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What is the relationship of PCOâ‚‚ in blood and alveolar air during gas exchange?

Carbon dioxide pressure in the blood is greater than carbon dioxide pressure in the alveolar air.

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What is the relationship between POâ‚‚ in the blood and in tissues?

Oxygen pressure in the blood is greater than oxygen pressure in the tissues.

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What is the relationship between PCOâ‚‚ in tissues and in the blood?

Carbon dioxide pressure in the tissues is greater than carbon dioxide pressure in the blood.

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What is low alveolar POâ‚‚ in Inspired Air?

Low alveolar oxygen due to abnormally low oxygen content. Higher altitude decreases it.

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What is Alveolar Ventilation?

The amount of air reaching the alveoli for gas exchange.

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What is HbO2 (oxyhemoglobin)?

Binding of oxygen to hemoglobin

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What does an increase in PO2 do

Shifts reaction to R (Hb + O2 -> HbO2) in lungs.

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What is a bicarbonate ion?

Most CO2 is transported in the blood.

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What is the Dorsal respiratory group:

Receives sensory input regarding CO2 blood levels, O2 levels and pH.

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What are Peripheral chemoreceptors?

Located in carotid bodies (located in carotid arteries).

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What are Central chemoreceptors?

Located in CNS (on ventral surface of medulla).

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What is low alveolar PO2 in Alveolar ventilation?

Low alveolar oxygen if alveolar ventilation is inadequate (hypoventilation).

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What is Ventral respiratory group (VRG)?

One region =Pre-Bötzinger complex - basic pacemaker activity (generates rhythms that control breathing)

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What is Breathing?

Bulk flow of air into and out of the lungs.

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What is alveolar hypoventilation?

Low alveolar oxygen due to reduced lung compliance or increased airway resistance.

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What can cause alveolar hypoventilation?

Decreased lung compliance, increased airway resistance, CNS depression

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What must happen to gas, before binding to hemoglobin?

Entering into the capillaries

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What is the effect of low alveolar POâ‚‚?

Decreases oxygen uptake.

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What does a decrease in PO2 do?

Shifts reaction to L (Hb + O2 <- HbO2) in tissues.

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What are pontine respiratory groups?

Located in the brainstem, output to the medulla to ensure a smooth respiratory rhythm.

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Control of Breathing?

Medulla, VRG, Phrenic nerve

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What conditions trigger increased ventilation via peripheral chemoreceptors?

↓Po₂, pH, and ↑Pco₂ initiate increase in ventilation.

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What do central chemoreceptors do?

Respond to changes in Pco, in the CSF

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Study Notes

  • Gas exchange and transport involves the exchange of oxygen and carbon dioxide in the body Ch 18
  • Chapter covers gas exchange in the lungs and tissues, gas transport in the blood, and regulation of ventilation

Introduction to Gas Exchange

  • The body requires oxygen and eliminates carbon dioxide
  • Hypoxia refers to insufficient oxygen levels in the body
  • Hypercapnia refers to elevated carbon dioxide levels in the body
  • To prevent hypoxia and hypercapnia, the body manages three regulated variables: oxygen, carbon dioxide, and pH

Gas Exchange in the Lungs and Tissues

  • Breathing facilitates the bulk movement of air into and out of the lungs.
  • Individual gases travel along partial pressure gradients until equilibrium, which allows for gas exchange
  • The total pressure of a gas mixture equals the sum of the pressures of each individual gas
  • Gas exchange occurs between alveoli and blood
  • The partial pressure of oxygen in the alveolar air is greater than in the blood
  • The partial pressure of carbon dioxide in the blood is greater than in the alveolar air
  • Gas exchange occurs between blood and tissues
  • The partial pressure of oxygen in the blood is greater than in the tissue
  • The partial pressure of carbon dioxide in the tissue is greater than in the blood

Lower Alveolar Oxygen

  • The level of oxygen affects oxygen uptake
  • Low alveolar oxygen results from abnormally low oxygen in the inspired air
  • Higher altitudes reduce oxygen partial pressure
  • Low alveolar oxygen stems from inadequate alveolar ventilation (hypoventilation)
  • Decreased lung compliance, is a factor, such as with asbestosis
  • Increased airway resistance can lowers oxygen levels, such as with COPD
  • Central nervous system (CNS) depression, from alcohol poisoning or drug overdose, may lower oxygen levels

Factors Affecting Gas Exchange in the Alveoli

  • Oxygen and carbon dioxide diffuse across a diffusion barrier between lung and blood
  • The barrier includes surfactant, alveolar epithelium, fused basement membranes, and the nucleus of endothelial cell, plasma, and red blood cells

Pathologies that Cause Hypoxia

  • Normal lung function facilitates efficient diffusion based on surface area, barrier permeability, and distance
  • Emphysema involves the destruction of alveoli, reducing the surface area for gas exchange
  • Fibrotic Lung Disease is typified by thickened alveolar membranes, slowing gas exchange and decreasing lung compliance
  • Pulmonary Edema occurs when fluid in the interstitial space increases the diffusion distance
  • Asthma is defined as increased airway resistance that diminishes alveolar ventilation

Gas Transport in the Blood

  • Gas enters the capillaries and first dissolves in the plasma
  • Dissolved gas accounts for less than 2% of oxygen in blood

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